Venous allografts for infrainguinal vascular bypass

Rebane, E; Tikko, H; Tunder, E; Lepner, Urmas; Helberg, A; Pulges, Andres; Vaasna, T.; Suba, S; Lieberg, J.; Tamm, V; Ellervee, T; Vasar, O

doi:10.1016/s0967-2109(96)00080-4

Cited by 23 publications

(22 citation statements)

References 24 publications

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“…Cold-stored venous homografts have been proven to be suitable conduits for distal revascularization in critical ischemia, especially in infected fields. There has been long-standing experience with preserved vein grafts, yielding excellent early results [16,17] . Graft disintegration is a particular problem in cold-stored venous allografts [18] .…”

Section: Discussionmentioning

confidence: 99%

Successful Human Vascular Reconstructions with Long-Term Refrigerated Venous Homografts

Galambos

Oláh

Banga³

et al. 2009

Eur Surg Res

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Fresh autologous vein grafts are commonly used for infrainguinal vascular reconstructions with good results. Previously we have confirmed the high viability index of homografts even after long-term storage at 4°C in tissue culture medium. In this clinical study, we have evaluated the in vivo efficiency of this storage method in humans with major peripheral graft infections. Between April 2006 and November 2008, data from patients who underwent graft excision and venous allograft reconstruction were collected prospectively (5 men, 2 women, mean age 68 years). Six patients had acute ischemia at the time of allograft reconstruction, while 3 had experienced anastomosis rupture. Allograft reconstruction was performed as an emergency procedure in 3 cases. The observed parameters included patient survival, limb salvage, persistence or recurrence of infection and allograft patency. In the follow-up period reoperation, excision or thrombectomy was necessary in 3 cases. There were no perioperative deaths, early amputations, persistent or recurrent infections. In conclusion, this study demonstrates the efficacy of long-term 4°C storage of venous allografts for revascularization in cases with peripheral bypass graft infection. We suggest that this technique is a useful option for graft preservation and propose a wide-scale introduction.

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Section: Discussionmentioning

confidence: 99%

Successful Human Vascular Reconstructions with Long-Term Refrigerated Venous Homografts

Galambos

Oláh

Banga³

et al. 2009

Eur Surg Res

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“…To our knowledge, only three series describing the use of venous allografts preserved at 4°C for infrainguinal bypass have been published: those by Van Reedt Dortland et al, 2 De Leersnijder et al, 3 and Rebane et al 4 Because all series including ours differ with regard to mean age, clinical stage, and proportion of above-knee, below-knee, and infrapopliteal bypasses, comparison of the incidence of aneurysmal dilatation and 5-year secondary patency rate is difficult (Table VII). Aneurysmal dilatation of venous allografts is probably related more to weaknesses in the vein wall (pathological greater saphenous veins) than to rejection for the reasons described above.…”

Section: Discussionmentioning

confidence: 99%

Venous Allografts Preserved at 4°C for Infrainguinal Bypass: Long-Term Results from 170 Procedures

Streinchenberger

Barjoud

Adeleine

et al. 2000

Annals of Vascular Surgery

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“…Die Venengewinnung kann von Hirntoten und von Lebendspendern erfolgen.Es sollte jeweils eine gesunde V.saphena magna entnommen werden, da nur so ein optimales Transplantationsergebnis erwartet werden kann.Die Verwendung von varikösen Venen ist mit technischen Hindernissen (Segmentanastomosierung) und der Gefahr späterer Aneurysmabildung verbunden und kann heute nicht mehr empfohlen werden [5,7,15].…”

Section: Gewinnung Des Transplantatsunclassified

Die homologe Venentransplantation zur kruropedalen arteriellen Rekonstruktion

et al. 2004

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Allogenic venous transplantation represents an alternative procedure for preventing leg amputation. This study reviewed the question of whether immunologic monitoring and immunosuppressive therapy provide results close to those of autologous reconstructions. Twenty-eight patients received 31 homologous venous transplants. The average age in this group of 15 women and 13 men was 64.5 years. Limbs in danger of amputation could be kept longer in two thirds of them. These promising results show the superiority of this method over the use of alloplastic material in regions with cruropedal vessels. Therefore, it can be recommended in acute leg ischemia with lack of autologous vascularity. Improving guidelines for indication will be an interesting research field, and more contributions are needed.

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Venous allografts for infrainguinal vascular bypass

Cited by 23 publications

References 24 publications

Successful Human Vascular Reconstructions with Long-Term Refrigerated Venous Homografts

Successful Human Vascular Reconstructions with Long-Term Refrigerated Venous Homografts

Venous Allografts Preserved at 4°C for Infrainguinal Bypass: Long-Term Results from 170 Procedures

Die homologe Venentransplantation zur kruropedalen arteriellen Rekonstruktion

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