Venous blood lactate evaluation in equine neonatal intensive care

Castagnetti, Carolina; Pirrone, Alessandro; Mariella, Jole; Mari, Gaetano

doi:10.1016/j.theriogenology.2009.09.018

Cited by 101 publications

(169 citation statements)

References 59 publications

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“…Additionally, better results were seen in cases of adult post-resuscitation syndrome treated with TH where lactate values did not increase further, but rather fell 18 . Studies in veterinary medicine have identified persistently elevated lactate levels as a reliable independent biomarker predicting mortality in critically ill newborn foals 19,20 . On the other hand, some animal studies suggest a neuroprotective effect if lactate is administered intraventricularly into the brain of newborn rats immediately after ischaemia.…”

Section: Discussionmentioning

confidence: 99%

Lactate as an early predictor of psychomotor development in neonates with asphyxia receiving therapeutic hypothermia

Polackova¹,

Šalounová²,

Kantor³

2018

BIOMED PAP

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Aims. This prospective study aimed to evaluate the relationship between persistently elevated lactate values in the arterial blood of newborns with grade II and III hypoxic ischemic encephalopathy (treated with therapeutic hypothermia) and psychomotor development at 24 months. Methods. 51 neonates of gestational age from 36 to 41 weeks receiving therapeutic hypothermia for moderate to severe hypoxic ischaemic encephalopathy had arterial blood lactate levels regularly analysed. At 24 months the infants' psychomotor development was evaluated and they were divided into two groups -those where the outcome was favourable (i.e. normal psychomotor development) and adverse (severe motor or sensory impairment or death). The lactate dynamics over time were retrospectively evaluated from the data collected, with the normal upper limit set at 4 mmol/L. Results. Of the 51 affected neonates, 7 died over the course of the study. 34 of the remaining 44 infants demonstrated normal psychomotor findings at 2 years old, with adverse findings in 10 cases. Although both groups experienced significant reductions in lactate over time, there were statistically significant differences between them regarding currently measured lactate levels. Conclusion.Absolute lactate values and their development over time can be a used as an auxiliary factor in making early estimates of the long-term outcome for newborns with neonatal asphyxia being treated with therapeutic hypothermia.

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Section: Discussionmentioning

confidence: 99%

Lactate as an early predictor of psychomotor development in neonates with asphyxia receiving therapeutic hypothermia

Polackova¹,

Šalounová²,

Kantor³

2018

BIOMED PAP

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“…For instances, ABG was used in one study to examine the effect of birth order in puppies delivered by caesarean section (Crissiuma et al 2010); in equine neonates ABG was used to study the relationship between blood lactate and neonatal diseases such as sepsis, septic and haemorrhagic shock, haematomas, trauma and prematurity or immaturity (Castagnetti et al 2010).…”

Section: How Do We Determine the Physiometabolic Profile?mentioning

confidence: 99%

Animal welfare in the newborn piglet: a review

Mota-Rojas¹,

Martı́nez-Burnes²,

Villanueva-García³

et al. 2012

Vet. Med.

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ABSTRACT:The objective of this review is to integrate clinical findings and laboratory analyses in such a way to improve the welfare of newborn piglets and achieve better prognoses of neonatal viability. Deaths during the intrapartum period account for a significant proportion of pre-weaning mortality in farms worldwide. Piglets which die during parturition generally have normal size and typically lack gross lesions at post-mortem examination. However, circulatory abnormalities in the umbilical cord help in assessing piglet viability. Cord lesions can be classified as normal (adhered), oedematous, congested or haemorrhagic and should always be evaluated in perinatal deaths. The likelihood of neonatal survival decreases rapidly as the severity of umbilical cord lesions increase. The physiometabolic blood profile which includes acid-base balance, degree of dehydration, mineral balance, metabolic expenditure and gas exchange are also useful clinical elements for properly assessing neonatal viability. Neonatal survival is notably reduced when the blood pH falls below 7.0, lactate rises above 90 mg/dl, bicarbonate drops below 10 mmol/l, or the pCO 2 increases above 110 mm/Hg. Blood calcium is also an excellent indicator of neonatal stress when used in combination with the other parameters mentioned above. Trembling due to an imbalance in the movement of calcium in muscle is also a factor involved in neonatal mortality. Neurological function in the newborn piglet could also be evaluated by adapting the Apgar score widely used in human perinatology. Neonates with scores lower than 6 in a 10 point scale have generally lower survival rates. The two most important indicators for this vitality score are breathing latency and bradycardia. If the neonate has apnoea for more than 5 min and the cardiac frequency does not increase to more than 110 beats per minute the prognosis for survival is rather poor.

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“…Glucose concentrations significantly increased across the time points evaluated, potentially because of colostrum intake. The lactate values at birth were superior to those described by Castagnetti et al (2010) for healthy foals, and the authors validated for the first time, the portable analyzer to assess blood lactate concentration in critically ill and healthy foals. But according to the authors, the analyzer seems to underestimate lactate values >5 mmol/L, and the veterinary should therefore interpret higher lactate concentrations critically and possibly monitor lactate concentration more frequently.…”

Section: Discussionmentioning

confidence: 87%

“…However, few authors have reported lactate concentrations in healthy newborn foals (Castagnetti et al 2010.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of neonatal vitality and blood glucose, lactate and cortisol concentrations in foals of the Paint Horse breed

et al. 2017

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RESUMO.-[Avaliação dos padrões de vitalidade neonatal, glicemia, lactato e cortisol em potros da raça PaintHorse.] A avaliação clínica dos recém-nascidos, bem como a definição da conduta terapêutica adotada representam expressivos desafios ao Médico Veterinário. O objetivo deste estudo foi avaliar a vitalidade neonatal pelo escore de Apgar modificado, glicemia, lactatemia e cortisol em neonatos equinos. Para tal, foram utilizados 20 potros da raça Paint Horse, nascidos em eutocia, durante as primeiras 48 horas de vida. O escore de Apgar modificado foi realizado ao nascimento e 10 minutos após, atribuindo-se notas de 0 a 10. As colheitas das amostras de sangue, para a realização das análises laboratoriais, ocorreram nos momentos ao nascimento, 4, 8, 12, 20 16, 20, 24, 36 Clinical evaluations of newborns, as well as defining the therapeutic decision, represent significant challenges to the veterinarian. This study aimed to evaluate neonatal vitality using the modified Apgar score and blood glucose, lactate, and cortisol concentrations in newborn equines. Twenty foals of the Paint Horse breed born by normal delivery were evaluated during the first 48 hours of life. The modified Apgar score was determined at birth and 10 minutes later, with values ranging from 0 to 10. Blood samples for the laboratory tests were collected at birth and at 4, 8, 12, 16, 20, 24, 36, and 48 hours. The mean Apgar score was significantly lower at birth than at 10 minutes (p < 0.001). Blood glucose concentrations increased significantly between birth (98.90 ± 35.97 mg/dL) and 8 hours (127.90 ± 27.15 mg/dL), stabilizing after the first 12 hours (148.95 ± 29.59 mg/dL). Serum lactate concentrations showed a significant decrease across the time points tested, with the highest value occurring at birth (5.48 ± 2.17 mmol/L) and stabilizing after 24 hours (2.76 ± 1.31 mmol/L). Cortisol concentrations significantly decreased (p < 0.01) between 4 (10.46 ± 7.46 µg/dL) and 48 hours (5.21 ± 3.35 µg/dL), with the highest value occurring 4 hours after birth. The common occurrence of laboratory abnormalities in healthy newborn foals reinforces the need to conduct regular clinical examinations and to develop laboratory reference values for different breeds and ages.INDEX TERMS: Neonate equine, apgar score, lactatemia, glycemia, neonatal stress.

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Venous blood lactate evaluation in equine neonatal intensive care

Cited by 101 publications

References 59 publications

Lactate as an early predictor of psychomotor development in neonates with asphyxia receiving therapeutic hypothermia

Lactate as an early predictor of psychomotor development in neonates with asphyxia receiving therapeutic hypothermia

Animal welfare in the newborn piglet: a review

Evaluation of neonatal vitality and blood glucose, lactate and cortisol concentrations in foals of the Paint Horse breed

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