Venous hypertensive myelopathy associated with cervical spondylosis

Okada, Seiji; Chang, Charles; Chang, Geraldine; Yue, James J.

doi:10.1016/j.spinee.2016.06.003

Cited by 13 publications

(8 citation statements)

References 12 publications

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“…[25]. Results of the previous study revealed that the MRI of the cervical spine demonstrated spinal canal stenosis due to disc bulging and flavum hypertrophy at the C5/C6 and C6/C7 levels as well as hyperintense area over the C5-C7 levels on T2-weighted images [22]. In the present study, three cases of Syringomyelia were found.…”

Section: Original Research Articlesupporting

confidence: 61%

“…Results of the study by Nishimura, H et al [21], suggested that when the percentage of the stance phase in the gait cycle increased to above 70%, the CSM patients had an increased fall risk. A case report and review of the literature reported that the patient developed cervical radiculopathy, followed by gait disturbance and motor weakness [22].…”

Section: Original Research Articlementioning

confidence: 99%

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Pattern recognition approach and clinico-radiological evaluation of compressive myelopathies at a tertiary care hospital

2020

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Background: Neuroimaging is indicated in most instances of new-onset myelopathy for clinico-radiological correlation in terms of diagnosis, recovery, and prediction of recurrence. Aim: This study was conducted to study the clinical profile of cases of Compressive Myelopathy and the pattern of spinal cord involvement, also to compare the sites of localisation of clinical diagnosis with MRI diagnosis. Methodology: The present study was a prospective study involving 30 patients. Patients with clinical suspicion of spinal cord disease of age group 20-80 years were included as study participants. The primary pulse sequences included T1 and T2 weighted images on MRI, the location of the lesion, its margins, signal intensity on both T1 and T2 weighted images was noted. Results: The majority of 53.33% of participants were aged between 51 to 60 years. Difficulty in walking was observed in 97% of participants. Men were more often affected than women. Cervical spondylosis was the commonest cause of compressive myelopathy in 57%. A most common pattern of spinal cord involvement was combined Anterior + Posterior cord involvement. The cervical site of localisation (54%) was the commonest followed by the thoracic and lumbar spinal cord. Conclusion: Myelopathies have male preponderance. The commonest cause of compressive myelopathy was Cervical spondylosis. Anterior plus posterior cord syndrome was the commonest pattern seen, followed by posterior cord syndrome, anterior cord syndrome being the least observed. MRI correlates well with a clinical diagnosis and is useful in suggesting the location of the lesion.

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Section: Original Research Articlesupporting

confidence: 61%

Section: Original Research Articlementioning

confidence: 99%

Pattern recognition approach and clinico-radiological evaluation of compressive myelopathies at a tertiary care hospital

2020

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“…The causes of NCS are many and complex, and in the early stages of clinical practice it was thought to be associated to mechanical compression, inflammatory responses of the nerve roots or autoimmune reactions [18] . As research progressed, it was found that in the physiological state, the spinal cord, nerves and blood vessels are in a delicate balance of relaxation and fixation both inside and outside the spinal canal; there is a large space not only laterally but also anterior and posterior in the spinal canal [19] .…”

Section: Discussionmentioning

confidence: 99%

Clinical observation of Long chiropractic treatment on patients with neurogenic cervical spondylosis

Wang

et al. 2022

Medicine

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Neurogenic cervical spondylosis is the most common type of cervical spondylosis, accounting for approximately 60% percent of the incidence of cervical spondylosis. Cervical spine Long manipulation and sling exercise training (SET) have obtained good therapeutic results in clinical rehabilitation. The aim of this study was to evaluate the effect of Long manipulation combined with SET on neurogenic cervical spondylosis. In this assessor-blind, randomized controlled trial, 90 eligible patients will be randomized into a combination treatment group (Long manipulation combined with SET), a Long manipulation group and a conventional massage group. The visual analogue score, the Neck Disability Index score, and muscle fatigue in the bilateral upper oblique and Musculus sternocleidomastoideus, using mean power frequency and median frequency from the surface electromyography frequency domain index, will be assessed before and after the intervention at 0 and 4 weeks, respectively.Trial registration: Registered in the Chinese Clinical Trial Registration Center with the number ChiCTR2100054978. Registered

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“…To date, the aetiology of SDAVF is still unclear, and it is generally accepted to be an acquired disease. Some scholars claim it could be induced by surgical operation and trauma [ 20 ]. Jellema et al found a small physiological shunt between the radicular artery and venous plexus through a postmortem study, indicating that the environmental factors might lead to disease onset [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Potential biomarkers of spinal dural arteriovenous fistula: C4BPA and C1QA

Wang

Yang

et al. 2022

J Neuroinflammation

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Background and purpose A major challenge in spinal dural arteriovenous fistula (SDAVF) is timely diagnosis, but no specific predictive biomarkers are known. Methods In the discovery cohort (case, n = 8 vs. control, n = 8), we used cerebrospinal fluid (CSF) and paired plasma samples to identify differentially expressed proteins by label-free quantitative proteomics. Further bioinformatics enrichment analyses were performed to screen target proteins. Finally, it was validated by ELISA in two of the new cohorts (case, n = 17 vs. control, n = 9), and univariate analysis, simple linear regression, and receiver operator characteristic (ROC) curve analysis were performed to evaluate the diagnostic potential. Results In the discovery cohort, the most overexpressed proteins were APOB and C4BPA in CSF samples of patients. The GO/KEGG enrichment analysis indicated that the upregulated proteins were mainly involved in the acute inflammatory response and complement activation. Hub-gene analysis revealed that APP might be the key protein in the molecular interaction network. In the validation cohort, C4BPA and C1QA were significantly overexpressed in the CSF of patients, averaging 3046.9 ng/ml and 2167.2 ng/ml, respectively. Simple linear regression demonstrated that levels of C1QA and C4 were positively correlated with total protein in CSF (R2 = 0.8021, p = 0.0005; R2 = 0.7447, p = 0.0013). The areas under the ROC curves of C4BPA and C1QA were 0.86 and 1.00, respectively. Conclusions This study was the first to identify C4BPA and C1QA as potential biomarkers for the diagnosis of SDAVF and revealed that complement pathway activation might be one of the molecular mechanisms for venous hypertension myelopathy.

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Venous hypertensive myelopathy associated with cervical spondylosis

Cited by 13 publications

References 12 publications

Pattern recognition approach and clinico-radiological evaluation of compressive myelopathies at a tertiary care hospital

Pattern recognition approach and clinico-radiological evaluation of compressive myelopathies at a tertiary care hospital

Clinical observation of Long chiropractic treatment on patients with neurogenic cervical spondylosis

Potential biomarkers of spinal dural arteriovenous fistula: C4BPA and C1QA

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