Venous Leg Ulcer: A Meta-analysis of Adjunctive Therapy with Micronized Purified Flavonoid Fraction

Coleridge-Smith, P.; Lok, C.; Ramelet, Albert‐Adrien

doi:10.1016/j.ejvs.2005.04.017

Cited by 145 publications

(101 citation statements)

References 24 publications

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“…Of the controlled studies, one is unpublished and the other had a follow up period of only two months. 61 There is insufficient good quality evidence on which to base a recommendation for MPFF in chronic venous leg ulcer.…”

Section: Micronized Purified Flavonoid Fractionmentioning

confidence: 99%

A Systematic Review and Meta-analysis of Exercise Intervention for the Treatment of Calf Muscle Pump Impairment in Individuals with Chronic Venous Insufficiency

Orr¹,

Klement²,

McCrossin³

et al. 2017

OWM

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++High quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias 1 + Well conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias 1 -Meta-analyses, systematic reviews, or RCTs with a high risk of bias 2 ++ High quality systematic reviews of case control or cohort studies High quality case control or cohort studies with a very low risk of confounding or bias and a high probability that the relationship is causal 2 + Well conducted case control or cohort studies with a low risk of confounding or bias and a moderate probability that the relationship is causal 2 -Case control or cohort studies with a high risk of confounding or bias and a significant risk that the relationship is not causal 3Non-analytic studies, eg case reports, case series NHS Quality Improvement Scotland (NHS QIS) is committed to equality and diversity and assesses all its publications for likely impact on the six equality groups defined by age, disability, gender, race, religion/belief and sexual orientation.SIGN guidelines are produced using a standard methodology that has been equality impact assessed to ensure that these equality aims are addressed in every guideline. This methodology is set out in the current version of SIGN 50, our guideline manual, which can be found at www.sign.ac.uk/guidelines/fulltext/50/index.html. The EQIA assessment of the manual can be seen at www.sign. ac.uk/pdf/sign50eqia.pdf. The full report in paper form and/or alternative format is available on request from the NHS QIS Equality and Diversity Officer.Every care is taken to ensure that this publication is correct in every detail at the time of publication. However, in the event of errors or omissions corrections will be published in the web version of this document, which is the definitive version at all times. This version can be found on our web site www.sign.ac.uk.This document is produced from elemental chlorine-free material and is sourced from sustainable forests.

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Section: Micronized Purified Flavonoid Fractionmentioning

confidence: 99%

A Systematic Review and Meta-analysis of Exercise Intervention for the Treatment of Calf Muscle Pump Impairment in Individuals with Chronic Venous Insufficiency

Orr¹,

Klement²,

McCrossin³

et al. 2017

OWM

View full text Add to dashboard Cite

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“…MPFF treatment was also associated with a shorter time to healing [146]. Other RCTs are reviewed by Kearon and colleagues [152].…”

Section: Micronized Purified Flavonoids Fractionmentioning

confidence: 99%

“…MPFF has been successfully used for treatment of venous leg ulcers caused by microcirculation damage induced by increased ambulatory venous pressure [146,147,149,150] and seems to have the highest clinical benefit among various pharmacological agents in patients with venous diseases [151]. In a meta-analysis of 5…”

Section: Micronized Purified Flavonoids Fractionmentioning

confidence: 99%

“…A micronized purified flavonoid fraction (MPFF) named Daflon 500 ® (Servier, Neuilly-Sur-Seine, France) consisting of 90% diosmin and 10% flavonoids expressed as hesperidin, has been reported to protect the microcirculation [146,147] and has been approved for clinical use and widely marketed in different countries.…”

Section: Micronized Purified Flavonoids Fractionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Miotto¹,

Striebel²,

Cho

et al. 2013

Drug and Alcohol Dependence

121

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Abstract:Reactive oxygen species (ROS) are widely believed to cause or aggravate several human pathologies such as neurodegenerative diseases, cancer, stroke and many other ailments. Antioxidants are assumed to counteract the harmful effects of ROS and therefore prevent or treat oxidative stress-related diseases. In this report, recent human studies exploring the efficiency of antioxidants in prevention and treatment of various diseases are reviewed. Few antioxidants including edaravone (for ischemic stroke in Japan), Nacetylcysteine (for acetaminophen toxicity), alfa-lipoic acid (for diabetic neuropathy) and some flavonoids (polyphenolic compounds present in dietary plants), such as micronized purified flavonoid fraction (diosmin and hesperidin) and oxerutins (for chronic venous insufficiency) as well as baicalein and catechins (for osteoarthritis) have found accepted clinical use. However, despite much enthusiasm in the 1980s and 1990s, many well-known agents such as antioxidant vitamins and also more recently developed compounds such as nitrones have not successfully passed the scrutiny of clinical trials for prevention and treatment of various diseases. This has given rise to a pessimistic view of antioxidant therapy, however, the evidence from human epidemiological studies about the beneficial effects of dietary antioxidants and preclinical in vitro and animal data are compelling. We have probably wasted too much time on agents like antioxidant vitamins instead of focusing on more disease specific, target-directed, highly bioavailable antioxidants. We here discuss possible reasons for the lack of success in some clinical trials and seek to provide some suggestions to be considered if antioxidant therapy is to succeed as an effective therapeutic strategy.

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“…In addition to these measures, pentoxifylline and micronized purified flavinoid fraction have demonstrated benefit (78,79).…”

Section: Noninterventional Managementmentioning

confidence: 99%

Endovascular Interventions for Acute and Chronic Lower Extremity Deep Venous Disease: State of the Art

Sista

Vedantham

Kaufman³

et al. 2015

Radiology

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Venous Leg Ulcer: A Meta-analysis of Adjunctive Therapy with Micronized Purified Flavonoid Fraction

Abstract: These results confirm that venous ulcer healing is accelerated by MPFF treatment. MPFF might be a useful adjunct to conventional therapy in large and long standing ulcers.

Cited by 145 publications

References 24 publications

A Systematic Review and Meta-analysis of Exercise Intervention for the Treatment of Calf Muscle Pump Impairment in Individuals with Chronic Venous Insufficiency

A Systematic Review and Meta-analysis of Exercise Intervention for the Treatment of Calf Muscle Pump Impairment in Individuals with Chronic Venous Insufficiency

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Endovascular Interventions for Acute and Chronic Lower Extremity Deep Venous Disease: State of the Art

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