Venous Thromboembolism and Other Venous Disease in the Tecumseh Community Health Study

Coon, William W.; Willis, Park W.; Keller, Jacob B.

doi:10.1161/01.cir.48.4.839

Cited by 502 publications

(248 citation statements)

References 3 publications

Supporting

Mentioning

215

Contrasting

Unclassified

Order By: Relevance

“…1 Other cross-sectional studies have estimated the prevalence of active venous FIGURE 1. Characteristic changes of chronic venous insufficiency consisting of red and blue-brown pigmentation, and dry scaly skin.…”

Section: Epidemiology and Natural Historymentioning

confidence: 99%

Chronic Venous Insufficiency and Venous Ulceration

Alguire

Mathes

1997

J Gen Intern Med

View full text Add to dashboard Cite

OBJECTIVE:To review and summarize the literature on the normal venous circulation of the leg, and the epidemiology, pathophysiology, and treatment of chronic venous insufficiency (CVI).DATA SOURCES: English-language articles identified through a MEDLINE search using the terms venous insufficiency or varicose ulcer and epidemiology, pathophysiology, diagnosis, and clinical trial (pt), and selected cross-references. STUDY SELECTION:Articles on epidemiology, pathophysiology, and treatment of CVI. Randomized, controlled studies were specifically sought for treatment efficacy. DATA EXTRACTION:Data were manually extracted from selected studies and reviews; emphasis was placed on information relevant to the general internist. pproximately 5 million people in the United States exhibit some evidence of chronic venous insufficiency (CVI) and between 400,000 and 500,000 of these individuals have or will develop a venous leg ulcer. 1-3 The signs of CVI include engorgement of the cutaneous veins and dependent edema in mildly affected patients to pigmentation, dermatitis, and ulceration in the more severe cases. Although most patients are asymptomatic, others have leg heaviness and aching or recurrent and recalcitrant leg ulcers punctuated by bouts of cellulitis. These more severe cases are associated with recurrent hospitalization, high health-care costs, and disability. 4,5 Venous insufficiency with trophic skin changes or ulceration is a frustrating problem, which many physicians approach with a sense of ennui. This may be due to the chronic and remitting nature of the problem, the need for lifestyle modification, inconvenient therapies, and contradictory information regarding medical and surgical management. Nevertheless, CVI, including ulceration, is a manageable problem. The purpose of this review is to present the normal anatomy and physiology of the venous circulation and to summarize the epidemiology, pathophysiology, and treatment of CVI. DATA SYNTHESIS: METHODSA MEDLINE search for relevant English-language articles published between 1966 and 1996 was completed using the following MeSH terms: venous insufficiency or varicose ulcer and epidemiology, pathophysiology, diagnosis, and clinical trial (pt). When selecting articles on treatment, randomized, controlled trials were reviewed whenever possible. Emphasis was placed on reviewing articles with clinical relevance for internal medicine physicians. ANATOMY AND NORMAL PHYSIOLOGYVenous blood from the skin and subcutaneous fat is collected in a system of superficial venules and veins that drain toward the deep venous system underneath the fascia via three major pathways: (1) through the long or short saphenous veins, which join the deep system at the saphenofemoral and saphenopopliteal junctions; (2) through the perforating veins originating from the long or short saphenous veins or their branches; or (3) directly into the deep venous system or bypass the deep system entirely and enter the pelvis. 6 Deep veins are categorized as either intramuscular or intermuscular; o...

show abstract

Section: Epidemiology and Natural Historymentioning

confidence: 99%

Chronic Venous Insufficiency and Venous Ulceration

Alguire

Mathes

1997

J Gen Intern Med

View full text Add to dashboard Cite

show abstract

“…An estimated 3 to 6 million chronic skin ulcers occur in patients every year in the United States. The most common underlying conditions are venous reflux, pressure, and diabetes mellitus 1,2,3,4,5 In the vast majority of surgical procedures, nearly all acute wounds heal by an orderly and timely process 6 , with a strength and integrity similar to normal skin. 7,8 Wounds refractory to moist healing, however, may be candidates for growth factor therapy, which is assumed to stimulate missing or dysfunctional components of the chronic wound [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

The Role of Vascular Endothelial Growth Factor in Wound Healing

Bao

Kodra

Tomic‐Canic

et al. 2009

Journal of Surgical Research

963

732

View full text Add to dashboard Cite

“…O aumento do risco de EP, de acordo com a elevação da faixa etária, foi descrito em alguns estudos 6,7,8 . Evidentes correlações entre idade e risco foram confirmadas no estudo realizado em Worcester 8 , que identificou 89% dos pacientes com EP com idade > a 40 anos, e no estudo de Framingham, que observou maior incidência de EP maciça nos pacientes de faixa etária mais alta 6 .…”

Section: Desordens De Coagulação (Trombofilias)unclassified