Venous thromboembolism in Croatia – Croatian Cooperative Group for Hematologic Diseases (CROHEM) study

Abstract

AimTo analyze the incidence and characteristics of venous thromboembolism (VTE) in Croatia.MethodsThe Croatian Cooperative Group for Hematologic Diseases conducted an observational non-interventional study in 2011. Medical records of patients with newly diagnosed VTE hospitalized in general hospitals in 4 Croatian counties (Šibenik-Knin, Koprivnica-Križevci, Brod-Posavina, and Varaždin County) were reviewed. According to 2011 Census, the population of these counties comprises 13.1% of the Croatian population.ResultsThere were 663 patients with VTE; 408 (61.54%) had deep vein thrombosis, 219 (33.03%) had pulmonary embolism, and 36 (5.43%) had both conditions. Median age was 71 years, 290 (43.7%) were men and 373 (56.3%) women. Secondary VTE was found in 57.3% of participants, idiopathic VTE in 42.7%, and recurrent VTE in 11.9%. There were no differences between patients with secondary VTE and patients with idiopathic VTE in disease recurrence and sex. The most frequent causes of secondary VTE were cancer (40.8%), and trauma, surgery, and immobilization (38.2%), while 42.9% patients with secondary VTE had ≥2 causes. There were 8.9% patients ≤45 years; 3.3% with idiopathic or recurrent VTE. Seventy patients (10.6%) died, more of whom had secondary (81.4%) than idiopathic (18.6%) VTE (P < 0.001), and in 50.0% VTE was the main cause of death. Estimated incidence of VTE in Croatia was 1.185 per 1000 people.ConclusionCharacteristics of VTE in Croatia are similar to those reported in large international studies. Improved thromboprophylaxis during the presence of risk factors for secondary VTE might substantially lower the VTE burden.

Adverse effects of Oxford-AstraZeneca COVID-19 vaccine among Egyptian healthcare workers

“…Our study found no vaccine related adverse effect of thrombosis, in contrast to a latest single study obtained from a study by Pulanić et al from Croatia that found an elevation in the incidence of mixed pulmonary embolism (PE) and deep venous thrombosis (DVT), but not extracted PE or extracted DVT [41] Pandemic lockdowns and restrictions on physical activity were postulated to be the cause [42].…”

Extensive Deep Venous Thrombosis in a Young Male Patient as the First Manifestation of a Rare Venous Anomaly – Inferior Vena Cava Duplication: Case Report

“…VTE is a multicausal disease with many interactions between diff erent acquired (immobilization, surgery, trauma, cancer, autoimmune disorders, pregnancy, oral contraceptive use, long distance airplane fl ight, etc.) and inherited prothrombotic factors (FV Leiden and FII 20210A mutations, defi ciencies of protein C, S and antithrombin, and elevations of procoagulant factors) 8 . Although it is in general a frequent disease, VTE is rare among young people; the incidence of VTE is less than 5 fi rst-time VTE per 100,000 per year among people younger than 15 years but increases sharply to 450-600 per 100,000 per year among people aged 80 years or older 1,3,5,8 .…”

“…and inherited prothrombotic factors (FV Leiden and FII 20210A mutations, defi ciencies of protein C, S and antithrombin, and elevations of procoagulant factors) 8 . Although it is in general a frequent disease, VTE is rare among young people; the incidence of VTE is less than 5 fi rst-time VTE per 100,000 per year among people younger than 15 years but increases sharply to 450-600 per 100,000 per year among people aged 80 years or older 1,3,5,8 . In the most recent study of VTE incidence in the Croatian population, just 8.9% of all patients with newly diagnosed VTE were patients aged 45 years or younger 8 .…”

“…Venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism (PE), is a frequent and important health problem in the world, as well as in Croatia, with estimated incidence between 1 and 2 per 1000 individuals per year [1][2][3][4][5][6][7][8] . VTE is a multicausal disease with many interactions between diff erent acquired (immobilization, surgery, trauma, cancer, autoimmune disorders, pregnancy, oral contraceptive use, long distance airplane fl ight, etc.)…”