Venous Thromboembolism in Pregnancy [39L]

Abstract

INTRODUCTION: Venous thromboembolism is one of the leading causes of pregnancy-related maternal death in developed countries. The incidence rate is much higher during the postpartum period with an overall incidence of 2.5 to 9.9 per 1000 METHODS: The data were obtained from the 1999-2015 Health Care Cost and Utilization Project, Nationwide Inpatient Sample (HCUP-NIS) and used to carry out a population-based cohort study. The purpose of our study is to trend the rate of VTE during pregnancy and postpartum period and the assessment of the risk factors using a large population-based administrative database from the United States. Logistic regression was used to calculate the odds ratio (OR) and corresponding 95% confidence intervals (CIs) of demographic and obstetrical determinants of VTEs. RESULTS: The overall incidence of VTE was in an upward trend until 2015 when it reached 20/10,000 pregnancies, with an average case fatality rate of 1.16%. VTE is associated with maternal age above 25, anemia, heart disease, hypertension, obesity, transfusion, C-section, postpartum hemorrhage and PET. Predictors of VTE fatalities included obesity, hypertension, PET, postpartum hemorrhage, PTB and DM. CONCLUSION: VTE is a condition with an increasing in incidence and is associated with a significant maternal morbidity and mortality. Multiple risk factors associated with VTE with obesity being the most significant in our study. Further research targeting risk factors and prevention in pregnancy is warranted.