Venous thromboembolism in the era of COVID-19

Kyriakoulis, Konstantinos G; Kokkinidis, Damianos G.; Kyprianou, Ioanna A; Papanastasiou, Christos A.; Archontakis‐Barakakis, Paraschos; Doundoulakis, Ioannis; Bakoyiannis, Christos; Giannakoulas, George; Palaiodimos, Leonidas

doi:10.1177/0268355520955083

Cited by 27 publications

(29 citation statements)

References 63 publications

(144 reference statements)

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“…Similar observation was reported by others, that D-dimer and rising D-dimer linked to mortality [31]. The observed elevation of D-dimer might be due to direct viral-related endothelial injury [35] and other known thrombosis risk factors [36][37][38]. Additionally, the D-dimer elevation can be seen in some patients due to sepsis-induced coagulopathy [39].…”

Section: Discussionsupporting

confidence: 85%

Clinical Characteristics and Predictors of Mortality in Minority Patients Hospitalized with COVID-19 Infection

Rizwan

Ogunti

Ahmed

et al. 2021

J. Racial and Ethnic Health Disparities

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Objectives To identify the early mortality predictors in minority patients hospitalized with coronavirus disease 2019 . Design Demographics, presenting characteristics, admission laboratory data, ICU admission, and mortality data were collected from 200 consecutively hospitalized patients with COVID-19. Results The mean (SD) age was 58.9 (15.1) years, 121(60.5%) were men, 143 (71.5%) were African Americans, and 33 (16.5%) were Latino. Common presenting symptoms were cough 130 (65.0%), shortness of breath 129 (64.5%), and fever 121 (60.5%). One or more comorbid illness occurred in 171 (85.5%) and common comorbidities were hypertension (130 (65.2%)), diabetes (100 (50.0%)) and chronic kidney disease (60 (30.0%)). Of the 200 patients, 71 (35.5%) were treated in the ICU, 47 (24.2%) received mechanical ventilation, 45 (22.5%) died, and 155(77.5%) patients discharged home alive. The non-survivors were significantly older and had elevated markers of inflammation, coagulation, and acute organ damage on presentation. Age ≥ 65 years (odds ratio (

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Section: Discussionsupporting

confidence: 85%

Clinical Characteristics and Predictors of Mortality in Minority Patients Hospitalized with COVID-19 Infection

Rizwan

Ogunti

Ahmed

et al. 2021

J. Racial and Ethnic Health Disparities

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“…Besides, respiratory physiology is altered in patients with obesity, resulting in decreased functional residual capacity and expiratory reserve volume, leading to subsequent ventilation−perfusion abnormalities and hypoxaemia [ 86 , 87 ]. In addition, obesity has been associated with a high risk of developing venous thromboembolism [ 88 ], which is frequently reported in COVID-19 cases and is correlated with a poor prognosis [ 89 ].…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of the association between obesity and COVID-19

Jiao

Lei

2020

Epidemiol. Infect.

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Owing to limited data, we conducted a meta-analysis to re-evaluate the relationship between obesity and coronavirus-2019 (COVID-19). Literature published between 1 January 2020 and 22 August 2020 was comprehensively analysed, and RevMan3.5 was used for data analysis. A total of 50 studies, including data on 18 260 378 patients, were available. Obesity was associated with a higher risk of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) infection (odds ratio (OR): 1.39, 95% confidence interval (CI) 1.25–1.54; P < 0.00001) and increased severity of COVID-19 (hospitalisation rate: OR: 2.45, 95% CI 1.78–3.39; P < 0.00001; severe cases: OR: 3.74, 95% CI 1.18–11.87; P: 0.02; need for intensive care unit admission: OR: 1.30, 95% CI 1.21–1.40; P < 0.00001; need for invasive mechanical ventilation: OR: 1.59, 95% CI 1.35–1.88; P < 0.00001 and mortality: OR: 1.65, 95% CI 1.21–2.25; P: 0.001). However, we found a non-linear association between BMI and the severity of COVID-19. In conclusion, we found that obesity could increase the risk of SARS-CoV2 infection and aggregate the severity of COVID-19. Further studies are needed to explore the possible mechanisms behind this association.

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“…Several theories have suggested that PE seen in COVID‐19 correspond to microthrombus of small‐caliber pulmonary arteries, and not always from an embolic origin in extremity veins. 4 …”

Section: Discussionmentioning

confidence: 99%

“…Since it was first described, it has been linked to an increased incidence of venous thromboembolism (VTE), along with hemostatic abnormalities. 1 , 2 This has been suggested to be caused by inflammation, platelet activation, endothelial dysfunction, and other factors 3 , 4 that occur in COVID‐19 patients.…”

mentioning

confidence: 99%

Duplex Ultrasound Screening for Deep and Superficial Vein Thrombosis in COVID‐19 Patients

Tung‐Chen

Calderón

Marcelo

et al. 2021

J of Ultrasound Medicine

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Background There is growing evidence regarding the venous thromboembolic (VTE) pathophysiology of coronavirus disease 2019 (COVID‐19). Several studies have reported varying incidences of this disease. Objectives The main purpose of this study was to determine the real incidence of deep or superficial vein thrombosis in COVID‐19. The study also aimed to identify risk and protective factors for VTE. Methods Patients were consecutively enrolled and assessed with a bilateral Duplex ultrasonography of lower limbs during hospitalization. The exam was repeated weekly until discharge, and then follow‐up for 1 month. Results Two‐hundred and thirty‐three patients were enrolled. Mean age was 54.4 years (SD 12.7) and 47.8% were female. About 127 patients (54.5%) had comorbidities. At enrollment, patients were normotensive and had normal saturation (95.6%—SD 1.6, with a respiratory rate of 19.1 rpm—SD 4.0), with 130 needing at least supplementary oxygen therapy (55.8%). About 147 patients (63.1%) had at least 1 Duplex ultrasonography study performed and 1.7% had 5 or more studies. One patient had a distal posterior tibial vein thrombosis, which showed signs of chronicity and was congruent with the patient history. Therefore, the incidence of thrombotic events was nearly zero. Discussion Our study results suggest that performing a Duplex Ultrasonography screening protocol in stable COVID‐19 patient populations, who may need hospitalization but are without symptoms of vein thrombosis, is not founded. We presumably emphasize the advantage of using intermediate LMWH doses as well as early walking in COVID‐19 patients.

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Venous thromboembolism in the era of COVID-19

Cited by 27 publications

References 63 publications

Clinical Characteristics and Predictors of Mortality in Minority Patients Hospitalized with COVID-19 Infection

Clinical Characteristics and Predictors of Mortality in Minority Patients Hospitalized with COVID-19 Infection

A meta-analysis of the association between obesity and COVID-19

Duplex Ultrasound Screening for Deep and Superficial Vein Thrombosis in COVID‐19 Patients

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