Venous Thrombosis and Congenital Absence of Inferior Vena Cava in a Patient with Menorrhagia and Pelvic Pain

Nichols, James Hastings; Gonzalez, Sara C.; Bellino, Paul J.; Bieber, Eric J.

doi:10.1016/j.jpag.2009.04.007

Cited by 10 publications

(6 citation statements)

References 12 publications

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“…8,10,12,14 A transient risk factor was found for only 10 patients: one after knee trauma, one after being bedridden for 2 days, one pregnancy with pre-eclampsia, three taking birth-control pills and four after travelling > 4 h by any means of transport (one each of our patients). 8,11,33,38,40 One patient had Behçet's disease, a disorder associated with a higher risk of venous thrombosis. A precipitating factor, mainly major physical exertion (13/63 [20.6%] patients) 8,10,12,14 could partially explain the mechanism of DVT in IVCA.…”

Section: Discussionmentioning

confidence: 99%

Inferior vena cava agenesis and deep vein thrombosis: 10 patients and review of the literature

et al. 2010

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Inferior vena cava agenesis (IVCA) is a rare condition, found in almost 5% of patients under 30 years old with unprovoked deep venous thrombosis (DVT). We describe 10 consecutive patients with IVCA-associated DVT and conducted an extensive literature review to investigate the typical spectrum of IVCA-associated DVT. Among our patients (eight men and two women; mean age, 25 ± 4.5 years), DVT followed intense and unusual (major) physical activity for eight of them. DVT was bilateral in six patients and unilateral in four. Ultrasonography was unable to detect IVCA, which was visualized by computed-tomography scans for seven patients, and magnetic resonance imaging and angiography for 10. Hereditary thrombophilia screening, to detect factor V Leiden or prothrombin gene heterozygosity (G20210A mutation), was positive for only two patients. Wearing elastic stockings and taking an indefinite or long-term vitamin K antagonist were prescribed for all 10 patients and nine complied with the latter. To date, 62 patients with IVCA-associated DVT have been reported in the English literature. Analysis of them and our patients yielded a typical spectrum of IVCA-associated DVT characteristics: IVCA occurs in young adults, particularly males, and is revealed by proximal DVT following major physical exertion. All were treated with a prolonged vitamin K antagonist and advised to wear elastic stockings. No precise duration of anticoagulation has been established.

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Section: Discussionmentioning

confidence: 99%

Inferior vena cava agenesis and deep vein thrombosis: 10 patients and review of the literature

et al. 2010

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“…In the lower venous system, the most common abnormalities are interrupted or duplex IVC, presumably secondary to disrupted embryonic development of the IVC itself. [502][503][504][505][506][507][508][509] However, in the upper venous system, thoracic outlet syndrome, eponymously named Paget-Schroetter syndrome, are believed to be due to chronic trauma to the subclavian vein secondary to reduced anatomic space for the vein usually as a result of an abnormal relationship with the fi rst rib, abnormal fi brous bands or muscle development in athletes . [510][511][512][513][514][515][516][517][518][519] Management of the venous thrombosis and the underlying structural abnormality has included acute anticoagulation; both local and systemic thrombolysis through a number of techniques; percutaneous angioplasty; thrombectomy; venous reconstruction; and in the case of PagetSchroetter syndrome, decompression of the thoracic inlet through removal of relevant bone and muscle.…”

Section: Children With Vte and Structurally Abnormally Venous Systemsmentioning

confidence: 99%

Antithrombotic Therapy in Neonates and Children

Monagle

Chan

Goldenberg

et al. 2012

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“…Our case highlights the potential for misdiagnosing pelvic DVT in this atypical population presenting with features such as pelvic pain and menorrhagia in young women 9. In addition, while AIVC is usually asymptomatic and often diagnosed incidentally, first presentations are often with venous thrombosis though fever and rigours have been described as well as subsequent lower-limb oedema 10…”

Section: Discussionmentioning

confidence: 81%

Pyrexia of unknown origin: inferior vena cava agenesis

Thein¹,

Menezes

Moran

2018

BMJ Case Reports

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A 26-year-old woman presented with a 5-day history of fever after returning from Bali. She denied sexual contact abroad. On examination, there was suprapubic tenderness and a widespread maculopapular rash. Malaria serology was negative and blood tests were normal except for an elevated C reactive protein. Treatment was initially with ceftriaxone, metronidazole and doxycycline, but her symptoms failed to improve. A CT pelvis suggested a possible tubo-ovarian abscess, a suspected inferior vena cava (IVC) anomaly and left internal iliac/femoral venous thrombosis. A gynaecology review demonstrated left tubo-ovarian tenderness and fullness. An MRI suggested pelvic inflammatory disease and thrombophlebitis affecting the pelvic veins; deep vein thrombosis (DVT) treatment was commenced. Further family history revealed thrombosis throughout multiple generations. Further imaging analysis demonstrated agenesis of the IVC with compensatory dilation of pelvic collaterals and an acute DVT of the deep pelvic venous system. The patient was discharged with direct oral anticoagulant therapy.

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Venous Thrombosis and Congenital Absence of Inferior Vena Cava in a Patient with Menorrhagia and Pelvic Pain

Cited by 10 publications

References 12 publications

Inferior vena cava agenesis and deep vein thrombosis: 10 patients and review of the literature

Inferior vena cava agenesis and deep vein thrombosis: 10 patients and review of the literature

Antithrombotic Therapy in Neonates and Children

Pyrexia of unknown origin: inferior vena cava agenesis

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