Venous thrombosis generation by means of high-intensity focused ultrasound

Delon‐Martin, Chantal; Vogt, C.; Chignier, E; Guers, C.; Chapelon, Jean‐Yves; Cathignol, D.

doi:10.1016/0301-5629(94)00095-6

Cited by 94 publications

(43 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HIFU can lead to vessel wall disruption and vascular occlusion, and the vascular damage could cause bone changes such as bone atrophy. Fractures can also occur at the sites of weakened bones [14][15][16][17]. In 11 cases from this study, decreased bone uptake at the HIFU treatment path accompanied adjacent bone fractures.…”

Section: Discussionmentioning

confidence: 64%

Whole-Body Bone Scan Findings after High-Intensity Focused Ultrasound (HIFU) Treatment

Seo

Sohn

et al. 2011

Nucl Med Mol Imaging

View full text Add to dashboard Cite

Purpose This study aims to examine the findings of 99m Tcdiphosphonate bone scans in cancer patients with a history of HIFU treatment. Methods Bone scan images of patients with a history of HIFU treatment for primary or metastatic cancer from January 2006 to July 2010 were retrospectively reviewed. Cases of primary bone tumor or HIFU treatment reaching only the superficial soft tissue layer were excluded. Results Bone scan images of 62 patients (26 female, 36 male; mean age 57±9 years) were studied. HIFU treatment was performed in the liver (n=40), pancreas (n=16), and breast (n=6). Mean interval time between HIFU treatment and bone scan was 106±105 days (range: 1-572 days). Of 62 scans, 43 showed diffusely decreased uptake of bone within the path of HIFU treatment: antero-axillary and/or posterior arcs of right 5th to 11th ribs in 34 cases after treatment of hepatic lesions; anterior arcs of 2nd to 5th ribs in 5 cases after treatment for breast tumors; and posterior arcs of left 9th to 11th ribs or thoracolumbar vertebrae in 4 cases after treatment for pancreas tumor. Of 20 patients who had bone scans more than twice, five showed recovered uptake of the radiotracer in the involved ribs in the follow-up bone scan. Conclusion Of 62 bone scans in patients with a history of HIFU treatment for primary or metastatic cancer, 69% presented diffusely decreased uptake in the bone in the path of HIFU treatment.

show abstract

Section: Discussionmentioning

confidence: 64%

Whole-Body Bone Scan Findings after High-Intensity Focused Ultrasound (HIFU) Treatment

Seo

Sohn

et al. 2011

Nucl Med Mol Imaging

View full text Add to dashboard Cite

show abstract

“…[7][8][9] In consideration of the role of vascular occlusion by HIFU, many studies demonstrated that HIFU could stop the bleeding from injuries of different organs. [10][11][12][13][14][15][16][17][18][19][20] Spleen haemostasis is one of the clinical issues we often face. HIFU is effective in achieving haemostasis in haemorrhagic spleen models of pigs and rabbits, 3,4 and no major adverse effects were observed.…”

Section: Discussionmentioning

confidence: 99%

High-intensity focused ultrasound ablation: an effective and safe treatment for secondary hypersplenism

Zhu¹,

Mei²,

L³

et al. 2014

BJR

View full text Add to dashboard Cite

Objective: Hypersplenism is a common disease. The conventional treatment is splenectomy and partial splenic embolization; however, both of them have high complication rates and technical defects. Therefore, safer and more effective techniques should be considered for the treatment of hypersplenism. High-intensity focused ultrasound (HIFU) may provide an effective and safe way for treatment of hypersplenism. Therefore, we conducted this study to assess the safety and efficacy of HIFU in treatment of secondary hypersplenism. Methods: A total of 28 patients who suffered from secondary hypersplenism were treated with HIFU ablation. All patients who underwent HIFU were closely followedup over a year. MRI scan was performed, and the spleens were observed. Blood counts and liver function tests were also carried out.Results: In the follow-up process, the levels of white blood cells and platelets in the blood after HIFU were significantly higher than those before HIFU, liver function also improved after HIFU treatment. In addition, the symptoms were ameliorated significantly or even disappeared. The MRI showed that the ablation area had turned into a non-perfused volume, and after 12 months of HIFU ablation, the ablated area shrank evidently; the sunken spleen formed a lobulated shape and the splenic volume decreased. Conclusion: HIFU ablation is a safe, effective and noninvasive approach for secondary hypersplenism. Advances in knowledge: For the first time we used HIFU ablation to treat secondary hypersplenism. It not only expands indications of HIFU but also provides better choice for the treatment of secondary hypersplenism.Hypersplenism is a common manifestation in cirrhotic patients with portal hypertension. Liangpunsakul et al 1 reported that 70-80% of cirrhotic patients with portal hypertension have different degrees of splenomegaly and hypersplenism. Hypersplenism is a clinical syndrome characterized by splenomegaly, a variable combination of anaemia, leucopenia and/or thrombocytopaenia, compensatory bone marrow hyperplasia, reduced immunity and improvement after splenectomy. 1 The conventional treatment for patients with hypersplenism is splenectomy. However, after the first report of overwhelming post-splenectomy infection, clinical practitioners started realizing the important immunological function of the spleen. What is more, splenectomy is associated with increased risk of splenic vein thrombosis, secondary thrombocythemia and infection, particularly with encapsulated micro-organisms. 2 Several studies have shown that the spleen is an organ with a variety of important functions such as anti-infection and antitumour immunity. Therefore, it is important to retain the splenic function as much as possible when using splenomegaly treatment. Recently, partial splenic embolization (PSE) has been used in the treatment of splenomegaly and hypersplenism, but it has high incidence of complications. Local ablation therapies, such as radiofrequency ablation (RFA) and microwave ablation, also have marked improvement for...

show abstract

“…Isolated endothelial damage has been produced in vivo by HIFU exposure without damage to the tunica media, adventitia or surrounding tissue [12,14,40], although this has not resulted in permanent vascular occlusion in the absence of acoustic cavitation or artificially elevated levels of fibrinogen, which makes the blood hypercoagulable and promotes formation of stable thrombus. It appears that HIFU exposures which do not produce inertial acoustic cavitation can damage the endothelium, but do not sufficiently expose subendothelial collagen to produce a clinically significant primary haemostatic response [62].…”

Section: Effect Of High-intensity Focused Ultrasound On Thrombogenesismentioning

confidence: 99%

“…Collateral circulation was seen to arise quickly following vascular occlusion [20], so while a distributing artery may be blocked the area is not automatically devascularized. Ultimately, the nature of the chronic inflammatory response will determine whether the vessel becomes patent again or remains permanently occluded and fibrosed [14,23].…”

Section: Contribution Of the Inflammatory Response And Repair Mechanismsmentioning

confidence: 99%

Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery

Shaw

Haar

Rivens

et al. 2014

J. R. Soc. Interface.

View full text Add to dashboard Cite

ReviewCite this article: Shaw CJ, ter Haar GR, Rivens IH, Giussani DA, Lees CC. 2014 Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery. J. R. Soc. High-intensity focused ultrasound (HIFU) is a non-invasive technology, which can be used occlude blood vessels in the body. Both the theory underlying and practical process of blood vessel occlusion are still under development and relatively sparse in vivo experimental and therapeutic data exist. HIFU would however provide an alternative to surgery, particularly in circumstances where serious complications inherent to surgery outweigh the potential benefits. Accordingly, the HIFU technique would be of particular utility for fetal and placental interventions, where open or endoscopic surgery is fraught with difficulty and likelihood of complications including premature delivery. This assumes that HIFU could be shown to safely and effectively occlude blood vessels in utero. To understand these mechanisms more fully, we present a review of relevant cross-specialty literature on the topic of vascular HIFU and suggest an integrative mechanism taking into account clinical, physical and engineering considerations through which HIFU may produce vascular occlusion. This model may aid in the design of HIFU protocols to further develop this area, and might be adapted to provide a non-invasive therapy for conditions in fetal medicine where vascular occlusion is beneficial.

show abstract

Venous thrombosis generation by means of high-intensity focused ultrasound

Cited by 94 publications

References 7 publications

Whole-Body Bone Scan Findings after High-Intensity Focused Ultrasound (HIFU) Treatment

Whole-Body Bone Scan Findings after High-Intensity Focused Ultrasound (HIFU) Treatment

High-intensity focused ultrasound ablation: an effective and safe treatment for secondary hypersplenism

Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery

Contact Info

Product

Resources

About