Ventilation, Blood Flow, and Their Inter‐Relationships

Prisk, G. Kim

doi:10.1002/9781118597309.ch16

Cited by 4 publications

(2 citation statements)

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“…LUAD can disrupt the delicate tissue architecture and compromise gas exchange across alveoli, which severely impact the quality of life and long-term survival of the patients. Ventilation, blood flow and their inter-relationship are the major determinants of gas exchange in the lungs ( 6 ). Thus, in order to care for patients effectively, clear insight into the lung function, especially the processes of ventilation and perfusion of LUAD is required.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Functional Imaging for Lung Adenocarcinoma: Combined MRI Assessment Based on IVIM-DWI and OE-UTE-MRI

et al. 2021

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PurposeThe goal of current study was to introduce noninvasive and reproducible MRI methods for in vivo functional assessment of lung adenocarcinoma (LUAD).MethodsForty-four patients with pathologically confirmed LUAD were included in this study. All the lesions were classified as adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), or invasive adenocarcinoma (IA). The IA lesions were further divided into five subtype patterns, including acinar, lepidic, papillary, micropapillary and solid. Tumors were grouped depending on predominant subtype: low grade (AIS, MIA or lepidic predominant), intermediate grade (papillary or acinar predominant) and high grade (micropapillary, or solid predominant). Spirometry was performed according to American Thoracic Society guidelines. For each patient, Intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) analysis and oxygen-enhanced MRI (OE-MRI) analysis were performed. Spearman’s test was used to assess the relationship between a) whole lung mean percent signal enhancement (PSE) and pulmonary function tests (PFTs) parameters; b) IVIM-derived parameters and PFTs parameters; c) tumor mean PSE and IVIM-derived parameters. Kruskal -Wallis tests were applied to test the difference of tumor mean PSE and IVIM-derived parameters between different histological tumor grades. Receiver operating characteristics (ROC) analysis was used to evaluate the diagnostic performance.ResultsWhole lung mean PSE was significantly positively correlated with PFTs parameters (r = 0.40 ~ 0.44, P < 0.05). f value derived from IVIM-DWI was significantly negatively correlated with PFTs parameters (r = -0.38 ~ -0.47, P < 0.05). Both tumor mean PSE (P = 0.030 < 0.05) and f (P = 0.022 < 0.05) could differentiate different histological grades. f was negatively correlated with tumor mean PSE (r = -0.61, P < 0.001). For the diagnostic performance, the combination of tumor mean PSE and f outperformed than using tumor mean PSE or f alone in both sensitivity and area under the ROC curve.ConclusionsThe combined measurement of OE-MRI and IVIM-DWI may serve as a promising method for the noninvasive and non-radiation evaluation of pulmonary function. Quantitative analyses achieved by OE-MRI and IVIM-DWI offer an approach of the classification of LUAD subtypes.

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Section: Introductionmentioning

confidence: 99%

Pulmonary Functional Imaging for Lung Adenocarcinoma: Combined MRI Assessment Based on IVIM-DWI and OE-UTE-MRI

et al. 2021

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“…The effects of long-term exposure to higher-than-terrestrial CO 2 concentrations have been investigated. 49 Modest initial increases in ventilation subside after a few days in microgravity, with persistent elevation of end-tidal CO 2 , though the hypercapnic ventilatory response remains essentially unaffected by microgravity. 50 In contrast, the hypoxic ventilatory response is blunted due to the loss of the hydrostatic pressure gradient between the heart and the carotid bodies, as when supine on Earth.…”

Section: Microgravitymentioning

confidence: 99%

Pulmonary Function in Human Spaceflight

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Connolly

2023

Semin Respir Crit Care Med

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Human spaceflight is entering a time of markedly increased activity fueled by collaboration between governmental and private industry entities. This has resulted in successful mission planning for destinations in low Earth orbit, lunar destinations (Artemis program, Gateway station) as well as exploration to Mars. The planned construction of additional commercial space stations will ensure continued low Earth orbit presence and destinations for science but also commercial spaceflight participants. The human in the journey to space is exposed to numerous environmental challenges including increased gravitational forces, microgravity, altered human physiology during adaptation to weightlessness in space, altered ambient pressure, as well as other important stressors contingent on the type of mission and destination. This chapter will cover clinically important aspects relevant to lung function in a normally proceeding mission; emergency scenarios such as decompression, fire, etc., will not be covered as these are beyond the scope of this review. To date, participation in commercial spaceflight by those with pre-existing chronic medical conditions is very limited, and hence, close collaboration between practicing pulmonary specialists and aerospace medicine specialists is of critical importance to guarantee safety, proper clinical management, and hence success in these important endeavors.

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Single-cell sequencing reveals lung cell fate evolution initiated by smoking to explore gene predictions of correlative diseases

Lei,

2024

Toxicology Mechanisms and Methods

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Ventilation, Blood Flow, and Their Inter‐Relationships

Cited by 4 publications

References 90 publications

Pulmonary Functional Imaging for Lung Adenocarcinoma: Combined MRI Assessment Based on IVIM-DWI and OE-UTE-MRI

Pulmonary Functional Imaging for Lung Adenocarcinoma: Combined MRI Assessment Based on IVIM-DWI and OE-UTE-MRI

Pulmonary Function in Human Spaceflight

Single-cell sequencing reveals lung cell fate evolution initiated by smoking to explore gene predictions of correlative diseases

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