Ventilation Inhomogeneity and Bronchial Basement Membrane Changes in Chronic Neutrophilic Airway Inflammation

Koucký, Václav; Uhlı́k, Jir̆ı́; Hoňková, Lenka; Koucky, Miroslav; Doušová, Tereza; Pohunek, Petr

doi:10.1016/j.chest.2019.10.023

Cited by 11 publications

(12 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Four studies used the Leeds CF criteria (or a modified version) [ 38 , 64 , 65 , 70 ]; two used the European consensus for antibiotic therapy against Pseudomonas aeruginosa in CF [ 75 , 104 ]; and one used the Copenhagen criteria [ 100 ]. The remaining studies developed a study-specific criterion, such as pathogen cultured in ⩾50% of samples from the past year [ 46 , 47 ] or isolation of the same pathogen on at least two occasions, ⩾3 months apart in a 1-year period [ 93 ].…”

Section: Resultsmentioning

confidence: 99%

Lower airway clinical outcome measures for use in primary ciliary dyskinesia research: a scoping review

et al. 2021

View full text Add to dashboard Cite

ObjectivesDisease-specific, well-defined, and validated clinical outcome measures are essential in designing research studies. Poorly defined outcome measures hamper pooling of data and comparisons between studies. We aimed to identify and describe pulmonary outcome measures that could be used for follow-up of patients with primary ciliary dyskinesia (PCD).MethodsWe conducted a scoping review by systematically searching Medline, Embase and Cochrane Systematic Review online databases for studies published from 1996 to 2020 that included ≥10 PCD adult and/or paediatric patients.ResultsWe included 102 studies (7289 patients). Eighty-three studies reported on spirometry, 11 on body plethysmography, 15 on multiple breath washout, 36 on high-resolution computed tomography (HRCT), 57 on microbiology, and 17 on health-related quality of life. Measurement and reporting of outcomes varied considerably between studies (e.g. different scoring systems for chest HRCT scans). Additionally, definitions of outcome measures varied (e.g. definition of chronic colonisation by respiratory pathogen), impeding direct comparisons of results.ConclusionsThis review highlights the need for standardisation of measurements and reporting of outcome measures to enable comparisons between studies. Defining a core set of clinical outcome measures is necessary to ensure reproducibility of results and for use in future trials and prospective cohorts.

show abstract

Section: Resultsmentioning

confidence: 99%

Lower airway clinical outcome measures for use in primary ciliary dyskinesia research: a scoping review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…There are six cross‐sectional studies, 32–34,37–39 one transverse longutinal 36 and one cohort study 35 . Table 4 illustrates and summarizes all the significant results.…”

Section: Resultsmentioning

confidence: 99%

In children with primary ciliary dyskinesia, which type of lung function test is the earliest determinant of decline in lung health: A systematic review

Zafar

Hall

2022

Pediatric Pulmonology

View full text Add to dashboard Cite

Background: Primary ciliary dyskinesia is a rare genetic disorder characterized by recurrent sinopulmonary infections and worsening obstructive lung disease. Kidney and brain involvement is less common and is associated with overlapping ciliopathies/syndromes. The lungs are impacted early in the course of the disease, so it is vital to monitor lung function and recognize any decline by doing appropriate lung function tests. This systematic review compares different lung function tests and analyzes which one becomes abnormal earlier in the disease.Methods: A systematic review was conducted following the methodology in the "Cochrane Handbook on Systematic Reviews for diagnostic tests." The Preferred Reporting Items for Systematic Review and Meta-Analyses were used to report the results. The risk of bias assessment was done using "The Cochrane Handbook for Systematic Reviews tool for interventional studies." A meta-analysis was not performed due to the small sample size. All studies were analyzed by using Joanna Briggs Institute's critical appraisal tool.Results: After screening for the duplication of results and applying inclusion and exclusion criteria, 14 studies were assessed by reading the full texts. Out of these, eight were finally included in this systematic review. The total sample size from all studies was 165, including 80 males. All the studies used spirometry as a lung function test, whereas multiple breath washout was used in five studies. Other tests used for comparison were computed tomography (CT), magnetic resonance imaging (MRI), cardiopulmonary exercise testing, 6-min walk test, DLCO, maximal inspiratory pressure, maximal expiratory pressure, and PaO 2 . Lung clearance index (LCI) by multiple breath washout had a stronger association with the structural changes on CT/MRI than spirometry indices like forced expiratory volume in 1 s (FEV1) and forced expiratory flow at 25% to 75% of lung volume .Conclusions: Based on the evidence from this systematic review, LCI becomes abnormal earlier than FEV1 or FEF 25-75 and positively correlates with the findings

show abstract

“…A potential reason may be the lack of strong or consistent structure-function correlations with histopathological measures. For example, reticular basement membrane thickness does not correlate with ventilation heterogeneity measured by inert gas washout in paediatric patients with asthma or severe wheeze (40,73). In contrast, increased ventilation heterogeneity in patients with CF correlated with reticular basement membrane thickness and HRCT scores of abnormal lung structure (73,74).…”

Section: Structure-function Relationships In Pathologymentioning

confidence: 94%

“…For example, reticular basement membrane thickness does not correlate with ventilation heterogeneity measured by inert gas washout in paediatric patients with asthma or severe wheeze (40,73). In contrast, increased ventilation heterogeneity in patients with CF correlated with reticular basement membrane thickness and HRCT scores of abnormal lung structure (73,74). There is circumstantial evidence that oscillometry is sensitive to airway remodelling in asthma, since the relationship between lung volume and respiratory system conductance (reciprocal of resistance) does not normalise following bronchodilator administration (75).…”

Section: Structure-function Relationships In Pathologymentioning

confidence: 99%

The need for physiological phenotyping to develop new drugs for airways disease

Chapman

King

Robinson

et al. 2020

Pharmacological Research

View full text Add to dashboard Cite

Ventilation Inhomogeneity and Bronchial Basement Membrane Changes in Chronic Neutrophilic Airway Inflammation

Cited by 11 publications

References 36 publications

Lower airway clinical outcome measures for use in primary ciliary dyskinesia research: a scoping review

Lower airway clinical outcome measures for use in primary ciliary dyskinesia research: a scoping review

In children with primary ciliary dyskinesia, which type of lung function test is the earliest determinant of decline in lung health: A systematic review

The need for physiological phenotyping to develop new drugs for airways disease

Contact Info

Product

Resources

About