Ventilation is greater in women than men, but the increase during acute altitude hypoxia is the same

Loeppky, Jack A.; Scotto, P.; Charlton, Gerald C.; Gates, Lee; Icenogle, Milton V.; Roach, Robert C.

doi:10.1016/s0034-5687(00)00221-8

Cited by 53 publications

(40 citation statements)

References 27 publications

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“…To our knowledge, this is the first study reporting an influence of the estrus cycle on respiratory rate in freely moving rats. Our observation however is to some extent in line with the notion that progesterone is a respiratory stimulant per se, as well in conjunction with estrogen (Tatsumi et al, 1995), and with clinical studies suggesting higher minute volume in women than in men (Loeppky et al, 2001), and higher minute volume during pregnancy (Tatsumi and Hannhart, 1995). A number of previous clinical studies also suggest that the minute volume is higher in the luteal phase than in the follicular phase (Dutton et al, 1989), but this difference may at least partly be because of differences in tidal volume rather than in respiratory rate (Das, 1998).…”

Section: Discussionsupporting

confidence: 91%

Association Between Estrus Cycle-Related Changes in Respiration and Estrus Cycle-Related Aggression in Outbred Female Wistar Rats

Olsson

Annerbrink

et al. 2002

Neuropsychopharmacol

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Premenstrual dysphoric disorder is characterized by irritability surfacing during the luteal phase of the menstrual cycle, and disappearing shortly after the onset of menstruation. Although the cardinal symptoms of premenstrual dysphoria are different from those of panic disorder, the two conditions share a number of traits indicating that they both may be associated with abnormalities in the regulation of respiration. Both subjects with panic disorder and subjects with premenstrual dysphoria are hence reported to display enhanced respiratory variability, and to experience anxiety when exposed to CO 2 . In the present study, the possible influence of the estrus cycle on respiratory parameters in outbred female rats of the Wistar strain was investigated. Before being tested with respect to respiration, the rats were subdivided into two groups: those displaying estrus cycle-related variation in aggression, as evaluated using the resident intruder paradigm, and those not showing aggression throughout the cycle. Whereas the former group was found to display higher respiratory rate during the diestrus phase than during the proestrus/estrus phase, no cycle-related variation in respiration was observed in animals not showing cycle-related variation in aggression. The results support previous studies indicating that the estrus cycle exerts an influence on respiration, and suggest that rats prone to cycle-related aggression are more sensitive also to the influence of hormonal cyclicity on respiration. The possible bearing of these findings for the aberration in respiration displayed by subjects with premenstrual dysphoria is discussed.

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Section: Discussionsupporting

confidence: 91%

Association Between Estrus Cycle-Related Changes in Respiration and Estrus Cycle-Related Aggression in Outbred Female Wistar Rats

Olsson

Annerbrink

et al. 2002

Neuropsychopharmacol

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“…However, in humans, the results are contradictory. For instance, it has been demonstrated that the response to hypoxia and hypercapnia is higher in the luteal when compared to the follicular phase of the menstrual cycle (Schoene et al, 1981;White et al, 1983;Takano, 1984bTakano, , 1988Williams and Krahenbuhl, 1997), but the chemosensitivity was not associated with hormonal fluctuation, according to Loeppjy et al (2001) and Muza et al (2001).…”

Section: Introductionmentioning

confidence: 99%

“…The reason for these conflicting results may be due to the fact that such studies have been performed either in the follicular or luteal phase, or in both, with data collection being made on only 1 day of these phases. Additionally, the menstrual cycle phases have been confirmed using different methodological approaches, by the documentation of the menstrual cycles and/or body temperature (Takano, 1984a;Chong and Enson, 2000;Matsuo et al, 2003), with or without hormonal measurement (White et al, 1983;Edwards et al, 1996;Beidleman et al, 1999;Jordan et al, 2000;Loeppjy et al, 2001;Muza et al, 2001). Moreover, prospective follow-up across several consecutive menstrual cycles has not been done.…”

Section: Introductionmentioning

confidence: 99%

Changes in peak expiratory flow and respiratory strength during the menstrual cycle

Silva

Viana

Sousa

2006

Respiratory Physiology & Neurobiology

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“…Gender differences in control of breathing have been reported in rats and human beings, especially in response to gas challenges such as hypoxia and hypercapnia [1, 2, 3]. These challenges are used experimentally to ascertain the capability of central and peripheral chemosensors to sense and of individuals to respond to alterations in oxygen and carbon dioxide levels in the blood and to determine if animals can maintain homeostasis [4].…”

Section: Introductionmentioning

confidence: 99%

Gender Comparisons of Control of Breathing and Metabolism in Conscious Mice Exposed to Cold

Schlenker

Hansen²,

Pfaff³

2002

Neuroendocrinology

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We evaluated the effects of 2 h of warm (24°C) and cold (6°C) exposure on metabolism and ventilation (v̇_E) in conscious male and female Harlan ICR Swiss Webster mice exposed to air, and 8% O₂ in N₂ (hypoxia) and to 5% CO₂ in O₂ (hypercapnia) for 2 min each at both temperatures. All cold-exposed mice increased O₂ consumption (v̇_O2), and maintained body temperature. Cold-exposed females doubled their tidal volume, increased their v̇_E fivefold, and doubled their ventilatory equivalent to v̇_O2 (v̇_E/v̇_O2). In contrast, cold-exposed males decreased tidal volume and doubled v̇_E relative to warm exposure. The ventilatory equivalent of males was similar during warm and cold exposure. During warm exposure, mice of both genders increased their ventilatory responses to both hypoxia and to hypercapnia by different mechanisms. In contrast, during cold exposure, these responses were blunted relative to air measurements in females and decreased below air values in males. Thus, cold exposure was able to elicit gender-specific ventilatory and metabolic responses.

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Ventilation is greater in women than men, but the increase during acute altitude hypoxia is the same

Cited by 53 publications

References 27 publications

Association Between Estrus Cycle-Related Changes in Respiration and Estrus Cycle-Related Aggression in Outbred Female Wistar Rats

Association Between Estrus Cycle-Related Changes in Respiration and Estrus Cycle-Related Aggression in Outbred Female Wistar Rats

Changes in peak expiratory flow and respiratory strength during the menstrual cycle

Gender Comparisons of Control of Breathing and Metabolism in Conscious Mice Exposed to Cold

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