With the continuous growth of energy demand, the advantages of nuclear power, such as high energy density, low emissions, and cleanliness, are gradually highlighted. However, the increasing capacity of the turbine generator in nuclear power plants has led to greater losses and critical heating issues. Designing an effective cooling system plays an important role in improving the rotor’s heat dissipation ability, especially under the condition of limited rotor space. In this study, the cooling effects of the rotor using a radial straight-type cooling structure and a composited radial–axial–radial cooling structure are compared and analyzed for a 1555 MVA hydrogen-cooled nuclear turbine generator. Three-dimensional fluid thermal coupled models of the rotor with both cooling structures are established, and corresponding boundary conditions are provided. The models are solved using the finite volume method. The flow law of cooling hydrogen gas inside the rotor and the temperature distribution of various parts of the rotor are studied in detail. Compared with the radial straight-type cooling structure, adopting the composited radial–axial–radial cooling structure can reduce the average temperature of the rotor field windings by 4.5 °C. The research results provide a reference for the design and optimization of the rotor cooling system for large-capacity nuclear turbine generators.