Ventilator-associated pneumonia (VAP) caused by Acinetobacter baumannii in view of the microbial properties of the ESKAPE group in neighbouring countries – Poland and Ukraine

Abstract

The increase in the clinical threat of ESKAPE pathogens is associated with high virulence and the presence of numerous mechanisms of antimicrobial resistance. The above characteristics of pathogens affect therapeutic failures as well as cause prolongation and increase of the cost of its treatment. Objective. The aim of this study was to evaluate and analyze Acinetobacter baumannii strains in relation to the remaining bacteria from the ESKAPE group that induced pneumonia in mechanically ventilated patients in two neighboring countries. Materials and method. The study was retrospective. 335 clinical materials were analyzed, mainly bronchoalveolar lavage gained for microbiological screen. The analyzed patients were in intensive care units (ICU) in selected hospitals in 2013 -2015, in Poland (154 patients) and in Ukraine (181 patients).Results. In the analysis of etiological agents of VAP caused by ESKAPE strains, Gram negative bacteria were predominant in both countries although particular species occurred at different frequencies in Poland and Ukraine. Multi-resistant strains of Acinetobacter baumannii were more frequently cultured from patients in Poland (26.9%) compared to those from Ukraine (14.6%).

Prevalence of Acinetobacter baumannii with multiple drug resistance isolated from patients with ventilator-associated pneumonia from 2010 to 2020 in the world: a systematic review and meta-analysis

“…The highest prevalence rates of MDR A. baumannii isolated from patients with VAP were observed in the studies conducted by Farag et al (1.00; 95% CI: 0.95−1.00) [20], Huang et al (1.00; 95% CI: 1.00−1.00) [32], Moreira et al (1.00; 95% CI: 0.92−1.00) [33], Brotfain et al (1.00; 95% CI: 0.99−1.00) [25], Shete et al (1.00; 95% CI: 0.94−1.00) [30], and Goel et al (95% CI: 0.93−1.00) [34]. On the contrary, the lowest prevalence rates were observed in the studies conducted by Adukauskienė and Čiginskienė (0.14; 95% CI: 0.07−0.24) [35] and Grochowalska et al (0.14; 95% CI: 0.10−0.20) [36]. The overall prevalence was 0.71 (95% CI: 0.59−0.81) (Fig.…”

The Resistome of ESKAPEE Pathogens in Untreated and Treated Wastewater: A Polish Case Study

“…ESKAPEE ( Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , Enterobacter spp., and Escherichia coli ) bacteria are increasingly associated with antibiotic resistance, which poses a serious threat to public health [ 8 , 9 ]. These bacteria harbor genes that encode resistance to the most popular classes of antibiotics, including vancomycin, methicillin, broad-spectrum β-lactams, carbapenems, fluoroquinolones, and aminoglycosides [ 10 , 11 , 12 ]. In 2019, the European Center for Disease Prevention and Control (ECDC) published a report on antibiotic resistance in ESKAPEE pathogens in the European Union [ 13 ].…”