Ventilatory capacity and exercise tolerance in patients with chronic stable heart failure

Clark, Andrew L.; Davies, L. Ceri; Francis, D.P.; Coats, Andrew J.S.

doi:10.1016/s1388-9842(00)80109-9

Cited by 5 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although pulmonary functions of HF patients show restrictive or obstructive characteristics most of HF patients have normal pulmonary function test results (Kindman et al 1994;Clark 2000). In addition, inspiratory muscle training has been shown to reduce dyspnea and increase the quality of life and functional status of HF patients due to increase in strength and endurance of respiratory muscles (McConnell et al 2003;Skobel et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Health Related Quality of Life in Patients Awaiting Heart Transplantation

Karapolat

Eyigör

Zoghi

et al. 2008

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Quality of life is an important outcome measure in patients with end-stage heart failure waiting for heart transplantation. The purpose of this study was to investigate the relationship between aspects of quality of life and physiological and psychosocial variables in patients with end-stage heart failure. A total of 123 patients participated in the study. The functional status was assessed with New York Heart Association (NYHA) functional classifi cation, a 6-minute walk test (6 MWT) and peak oxygen uptake (pVO 2 ). Health related quality of life (HRQOL) was measured with Medical Outcomes Study, 36-item Short Form Survey (SF-36), and Minnesota Living with Heart Failure Questionnaire (MLHFQ). Beck Depression Inventory (BDI) and State-Trait Anxiety Inventory (STAI) were used to assess psychological symptoms. A signifi cant relationship was found between HRQOL (SF-36 and MLHFQ) and functional status (NYHA, 6 MWT and pVO 2 ) ( p < 0.05). Psychological symptoms (BDI) were associated with HRQOL ( p < 0.05). In addition to clinical derangements, functional limitation and psychological distress can lead to limitations in activities of daily life through impairment of quality of life. It would be helpful to evaluate psychological symptoms and quality of life in patients with end-stage heart failure besides routine clinical evaluations.health related quality of life; heart failure; functional capacity; psychological variables. Tohoku

show abstract

Section: Discussionmentioning

confidence: 99%

Health Related Quality of Life in Patients Awaiting Heart Transplantation

Karapolat

Eyigör

Zoghi

et al. 2008

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…Loss of physical ability contributes to a decline in functional ability and to a decreased quality of life. Short‐term exercise improves functional status and quality of life (Clark, Davies, Francis, & Coats, 2000; Delagardelle et al, 1999; Owen & Croucher, 2000). If participation in exercise is continued, it is expected that this downward spiral will be reversed.…”

Section: Functional Status and Quality Of Lifementioning

confidence: 99%

“…The study was strengthened by our use of a control group of exercisers who did not receive the intervention. Other exercise studies have used HF patients who do not participate in exercise training as a control group (Clark et al, 2000; Keteyian et al, 1996). In this study, both groups of patients followed a standardized exercise protocol that permitted the independent effect of the adherence intervention to be tested.…”

Section: Limitations and Strengthsmentioning

confidence: 99%

Effects of an Exercise Adherence Intervention on Outcomes in Patients with Heart Failure

Duncan

Pozehl²

2003

Rehabilitation Nursing

View full text Add to dashboard Cite

The purpose of this study was to determine how an exercise adherence intervention affects the physiological, functional, and quality of life outcomes of patients with heart failure (HF). Sixteen HF patients were randomly assigned to an exercise-only group (n = 8) or to an exercise-with-adherence group (n = 8). Two of the 16 people died from nonexercise related causes during the study and were not included in the analysis. The intervention was tested over a 24-week period in which patients participated in a 12-week supervised exercise program (Phase 1) followed by 12 weeks of unsupervised home exercise (Phase 2). The intervention format was one of individualized graphic feedback on exercise goals and participation and problem-solving support by nurses. Results indicate that patients who received the intervention exercised more frequently and experienced improved outcomes during both phases. The adherence intervention may encourage HF patients to continue to exercise and thereby maintain the health benefits gained in both phases of an exercise program.

show abstract

“…The underlying sex‐specific mechanism(s) for this trend remain poorly resolved and seem independent of cardiac function . Exercise intolerance in patients with HFrEF is poorly correlated with cardiac dysfunction and is accepted that peripheral impairments, including skeletal muscle abnormalities, play a large role in exercise intolerance in HFrEF . Mitochondria represent the key site for cellular energy production, and skeletal muscle mitochondrial impairments in HFrEF patients could predispose towards exercise intolerance.…”

Section: Introductionmentioning

confidence: 99%

Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure

Garnham

Roberts

Caspi

et al. 2019

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

Background Previous studies in heart failure with reduced ejection fraction (HFrEF) suggest that skeletal muscle mitochondrial impairments are associated with exercise intolerance in men. However, the nature of this relationship in female patients remains to be elucidated. This study aimed to determine the relationship between skeletal muscle mitochondrial impairments and exercise intolerance in male and female patients with HFrEF. Methods Mitochondrial respiration, enzyme activity, and gene expression were examined in pectoralis major biopsies from age‐matched male (n = 45) and female (n = 11) patients with HFrEF and healthy‐matched male (n = 24) and female (n = 11) controls. Mitochondrial variables were compared between sex and related to peak exercise capacity. Results Compared with sex‐matched controls, complex I mitochondrial oxygen flux was 17% (P = 0.030) and 29% (P = 0.013) lower in male and female patients with HFrEF, respectively, which correlated to exercise capacity (r = 0.71; P > 0.0001). Female HFrEF patients had a 32% (P = 0.023) lower mitochondrial content compared with controls. However, after adjusting for mitochondrial content, male patients demonstrated lower complex I function by 15% (P = 0.030). Expression of key mitochondrial genes regulating organelle dynamics and maintenance (i.e. optic atrophy 1, peroxisome proliferator‐activated receptor γ coactivator‐1α, NADH:ubiquinone oxidoreductase core subunit S1/S3, and superoxide dismutase 2) were selectively lower in female HFrEF patients. Conclusions These data provide novel evidence that HFrEF induces divergent sex‐specific mitochondrial phenotypes in skeletal muscle that predispose towards exercise intolerance, impacting mitochondrial ‘quantity' in female patients and mitochondrial ‘quality' in male patients. Therapeutic strategies to improve exercise tolerance in HFrEF should consider targeting sex‐specific mitochondrial abnormalities in skeletal muscle.

show abstract

Ventilatory capacity and exercise tolerance in patients with chronic stable heart failure

Cited by 5 publications

References 0 publications

Health Related Quality of Life in Patients Awaiting Heart Transplantation

Health Related Quality of Life in Patients Awaiting Heart Transplantation

Effects of an Exercise Adherence Intervention on Outcomes in Patients with Heart Failure

Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure

Contact Info

Product

Resources

About