Ventilatory capacity indices in Malawian children

Zverev, Yuriy; Gondwe, Mzamose

doi:10.4314/eamj.v78i1.9105

Cited by 11 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secondary interpretation used a locally derived reference range [11], with LLN of 80% predicted. Results are presented as “percentage of normal” given uncertain population standard errors.…”

Section: Methodsmentioning

confidence: 99%

Clinical Characteristics and Lung Function in Older Children Vertically Infected With Human Immunodeficiency Virus in Malawi

et al. 2015

View full text Add to dashboard Cite

BackgroundAntiretroviral therapy (ART) has led to increased survival of children with vertically acquired human immunodeficiency virus infection. Significant morbidity arises from respiratory symptoms, but aetiology and pulmonary function abnormalities have not been systematically studied.MethodsHuman immunodeficiency virus-positive children aged 8–16 years were systematically recruited within clinics in Blantyre, Malawi. Clinical review, quality of life assessment, spirometry, and chest radiography were performed.ResultsOne hundred sixty participants had a mean of age 11.1 (range, 8–16) years and 50.0% were female. Cough was present in 60 (37.5%) participants, and 55 (34.4%) had moderate or severe dyspnoea. Thirty-four (22.1%) participants had digital clubbing. Thirty-three (20.6%) participants were hypoxic at rest. One hundred eighteen (73.8%) of the children were receiving ART; median CD4 count was 698 cells/µL in these compared with 406 cells/µL in ART-naive individuals (P < .001). From 145 spirometry traces (90.6%), mean forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were 1.06 and 0.89 standard deviations below predicted mean, respectively. Twenty-one (14.5%) traces demonstrated obstructive defects and 26 (17.9%) reduced FVC. Lung function abnormality was not associated with any clinical findings. Of the 51 individuals with abnormal lung function, the mean increase in FEV1 after salbutamol was 3.8% (95% confidence interval, 0.02–7.53). “Tramlines” and ring shadows were seen on chest radiographs in over half of cases.ConclusionsSymptoms of chronic lung disease were highly prevalent with 2 main clinical phenotypes: “cough” and “hypoxia”. Lung function abnormalities are common, poorly responsive to bronchodilators, and apparent throughout the age range of our cohort. Pathological causes remain to be elucidated. Cough and hypoxic phenotypes could be a useful part of diagnostic algorithms if further validated.

show abstract

Section: Methodsmentioning

confidence: 99%

Clinical Characteristics and Lung Function in Older Children Vertically Infected With Human Immunodeficiency Virus in Malawi

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Scores of ≤2 were considered to represent stunting and wasting, respectively. Predicted spirometric indices were calculated using age-, sex-, and height-adjusted standards in healthy Malawian schoolchildren [17]. Quantitative interrelationships were examined using Spearman rank correlation coefficient: HRCT lobar scores were summed to provide global HRCT scores for specific variables.…”

Section: Methodsmentioning

confidence: 99%

Chronic Lung Disease in Adolescents With Delayed Diagnosis of Vertically Acquired HIV Infection

Ferrand

Desai²,

Hopkins

et al. 2012

Clinical Infectious Diseases

104

176

View full text Add to dashboard Cite

show abstract

“…FEV 1 and FVC, which according to the standards generally applicable in the Western World are ‘dependent’ on (B‐v), are relatively lower than those of their Western World counterparts. The onset of adolescence with its changes in body proportions does not considerably influence the relationship between the ratios of maximal ventilatory capacity and anthropometric variables (Zverev & Gondwe, ).…”

Section: Discussionmentioning

confidence: 99%

The multi‐ethnic global lung initiative 2012 and Third National Health and Nutrition Examination Survey reference values do not reflect spirometric measurements in Black boys and men from Tanzania

Rębacz-Maron

2016

Clin Physio Funct Imaging

View full text Add to dashboard Cite

Black people; forced expiratory volume in one second; FEV 1 /FVC; forced vital capacity; GLI2012; PEF; reference valuesThe interpretation of spirometric results of Black Africans according to reference standards based on data from outside their native environment may lead to the wrong conclusions. This article aims to characterize the ventilatory capacity of boys and men from Tanzania according to forced expiratory volume in one second (FEV 1 ), forced vital capacity (FVC), peak expiratory flow (PEF) and FEV 1 /FVC based on the collected anthropological material and to compare them to NHANES III, Third National Health and Nutrition Examination Survey (NHANES III) African American predicted values and GLI2012 equations. The analysis included spirometric measurements of n = 295 participants from Tanzania. Pearson's correlation analysis and the backward stepwise multiple regression analysis were performed. FEV 1 , FVC, PEF and FEV 1 /FVC results were compared to the NHANES III African American predicted values as well as to the GLI2012 equations. FEV 1 measurements are lower than the reference values according to NHANES III and GLI2012 equations by 22Á1% and 25Á8%. FVC results fell short of the NHANES III predicted by 29Á5% and of GLI2012 by 32Á5%. The average %FEV 1 /FVC scores for the boys and men exceeded the recommended GLI2012 predicted by 10Á5-15Á2%. All the spirometric measurements included in the analysis were statistically significantly correlated with age, body height, sitting height, trunk length and body weight. The application of prediction formulae developed for non-African populations overestimates the values for Black Africans. The results of spirometric measurements are ecosensitive and dependent on various external (environmental) factors.

show abstract

Ventilatory capacity indices in Malawian children

Cited by 11 publications

References 0 publications

Clinical Characteristics and Lung Function in Older Children Vertically Infected With Human Immunodeficiency Virus in Malawi

Clinical Characteristics and Lung Function in Older Children Vertically Infected With Human Immunodeficiency Virus in Malawi

Chronic Lung Disease in Adolescents With Delayed Diagnosis of Vertically Acquired HIV Infection

The multi‐ethnic global lung initiative 2012 and Third National Health and Nutrition Examination Survey reference values do not reflect spirometric measurements in Black boys and men from Tanzania

Contact Info

Product

Resources

About