Ventilatory Response to Carbon Dioxide in Newborn Infants

Krauss, Alfred N.; Klain, David B.; Waldman, Stephanie; Auld, Peter A. M.

doi:10.1097/00132586-197604000-00044

Cited by 5 publications

(6 citation statements)

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“…The slope of the ventilatory response to CO 2 in fullterm human infants is apparently similar to that observed in adults, although they start from about a 4 torr lower Pa CO2 (Krauss et al, 1975). In studies of preterm and term monkeys, there is a progressive increase in the slope of the CO 2 response over the first 3 weeks of life.…”

Section: Total Ventilationsupporting

confidence: 60%

Comparative Control of Respiration

Hazari¹,

Farraj²

2015

Comparative Biology of the Normal Lung

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Section: Total Ventilationsupporting

confidence: 60%

Comparative Control of Respiration

Hazari¹,

Farraj²

2015

Comparative Biology of the Normal Lung

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Section: Development Of Co 2 Sensitivity In Ratsmentioning

confidence: 99%

“…In several mammals, ventilatory CO 2 sensitivity is well developed at birth with minimal changes in the neonatal period (6,7,23,25,27,30,35,41,45). Rats are exceptional and in some respects are comparable to preterm infants (23,34) in that CO 2 sensitivity undergoes major changes during the neonatal period (1,3,9,32,34,41). In the present study, the CO 2 sensitivity of all three rat strains differed from some (32,37,41), previous studies that reported a ventilatory response to CO 2 at P0 and P1 that then declined and/or was absent at P5 to P7.…”

Section: Development Of Co 2 Sensitivity In Ratsmentioning

confidence: 99%

Postnatal developmental changes in CO₂sensitivity in rats

Davis¹,

Solhied²,

Castillo³

et al. 2006

Journal of Applied Physiology

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Ventilatory sensitivity to CO(2) in awake adult Brown Norway (BN) rats is 50-75% lower than in adult Sprague-Dawley (SD) and salt-sensitive Dahl S (SS) rats. The purpose of the present study was to test the hypothesis that this difference would be apparent during the development of CO(2) sensitivity. Four litters of each strain were divided into four groups such that rats were exposed to 7% inspired CO(2) for 5 min in a plethysmograph every third day from postnatal day (P) 0 to P21 and again on P29 and P30. From P0 to P14, CO(2) exposure increased pulmonary ventilation (Ve) by 25-50% in the BN and SD strains and between 25 to over 200% in the SS strain. In all strains beginning around P15, the response to CO(2) increased progressively reaching a peak at P19-21 when Ve during hypercapnia was 175-225% above eucapnia. There were minimal changes in CO(2) sensitivity between P21 and P30, and at both ages there were minimal between-strain differences. At P30, the response to CO(2) in the SS and SD strains was near the adult response, but the response in the BN rats was 100% greater at P30 than in adults. We conclude that 1) CO(2)-sensing mechanisms, and/or mechanisms downstream from the chemoreceptors, change dramatically at the age in rats when other physiological systems are also maturing ( approximately P15), and 2) there is a high degree of age-dependent plasticity in CO(2) sensitivity in rats, which differs between strains.

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“…A significant increase in V t , accompanied by a prolonged Tj, resulted in a net decrease in respiratory frequency. 13 As results from this study demonstrate, frequency falls because larger V t require longer inspiratory times. However, it must be pointed out that the activity of the Hering-Breuer reflex during hypercapnia must be interpreted with care.…”

Section: Discussionmentioning

confidence: 56%

Control of Inspiratory Timing in Newborn Infants

Krauss

Lewis²,

Silberman³

et al. 1992

Amer J Perinatol

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In order to determine if inspiratory time in preterm infants was influenced by lung volume, two studies were carried out. In the first investigation, carbon dioxide was used to stimulate tidal volume to a level three to six times normal. The anticipated decrease in inspiratory time at increased tidal volumes was not found. These preterm infants behaved in a similar fashion to vagotomized animals studied in the same way by Clark and von Euler. In the second investigation, Hering-Breuer activity was measured in relation to lung volume changes occurring with growth, measured in a body plethysmograph. Although thoracic gas volume correlated well with age and weight, inspiratory slowing with airway occlusion was found to be independent of both age and lung volume. These investigations suggest that neurologic factors have a significant influence on the inspiratory time in newborn human infants.

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Ventilatory Response to Carbon Dioxide in Newborn Infants

Cited by 5 publications

References 0 publications

Comparative Control of Respiration

Comparative Control of Respiration

Postnatal developmental changes in CO₂sensitivity in rats

Control of Inspiratory Timing in Newborn Infants

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Ventilatory Response to Carbon Dioxide in Newborn Infants

Cited by 5 publications

References 0 publications

Comparative Control of Respiration

Comparative Control of Respiration

Postnatal developmental changes in CO2sensitivity in rats

Control of Inspiratory Timing in Newborn Infants

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Postnatal developmental changes in CO₂sensitivity in rats