Ventilatory response to muscle spindle stimulation by succinylcholine in cats

Gautier, H.; Lacaisse, A; Detours, P.

doi:10.1016/0034-5687(69)90021-8

Cited by 23 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Skeletal muscle afferent fibers are traditionally divided into four groups according to their conduction velocity and, therefore, their degree of myelinisation. Group I and II fibers are the largest myelinated fibers that innervate muscle spindle and tendon organs; their contribution to exercise hyperpnea has been suggested (7,13,23) but remains uncertain (35,45,48,57,82). It is only recently that the receptive properties of the group III and IV muscle afferent fibers (i.e., small myelinated or unmyelinated fibers) have been more carefully and systematically analyzed (33, 47, 49-51, 54, 59-61, 63).…”

Section: On the Receptive Properties Of Group III And Iv Afferent Fibmentioning

confidence: 99%

Sensing vascular distension in skeletal muscle by slow conducting afferent fibers: neurophysiological basis and implication for respiratory control

Haouzi¹,

Chenuel²,

Huszczuk³

2004

Journal of Applied Physiology

View full text Add to dashboard Cite

This review examines the evidence that skeletal muscles can sense the status of the peripheral vascular network through group III and IV muscle afferent fibers. The anatomic and neurophysiological basis for such a mechanism is the following: 1) a significant portion of group III and IV afferent fibers have been found in the vicinity and the adventitia of the arterioles and the venules; 2) both of these groups of afferent fibers can respond to mechanical stimuli; 3) a population of group III and IV fibers stimulated during muscle contraction has been found to be inhibited to various degrees by arterial occlusion; and 4) more recently, direct evidence has been obtained showing that a part of the group IV muscle afferent fibers is stimulated by venous occlusion and by injection of vasodilatory agents. The physiological relevance of sensing local distension of the vascular network at venular level in the muscles is clearly different from that of the large veins, since the former can directly monitor the degree of tissue perfusion. The possible involvement of this sensing mechanism in respiratory control is discussed mainly in the light of the ventilatory effects of peripheral vascular occlusions during and after muscular exercise. It is proposed that this regulatory system anticipates the chemical changes that would occur in the arterial blood during increased metabolic load and attempts to minimize them by adjusting the level of ventilation to the level of muscle perfusion, thus matching the magnitudes of the peripheral and pulmonary gas exchange.

show abstract

Section: On the Receptive Properties Of Group III And Iv Afferent Fibmentioning

confidence: 99%

Sensing vascular distension in skeletal muscle by slow conducting afferent fibers: neurophysiological basis and implication for respiratory control

Haouzi¹,

Chenuel²,

Huszczuk³

2004

Journal of Applied Physiology

View full text Add to dashboard Cite

show abstract

“…Studies in resting animals showed that the activa- (Gautier et al, 1969;Leitner & Dejours, 1971) and also group III-IV muscle afferents (McCloskey & Mitchell, 1972;Tibes, 1977) increased minute ventilation (VE) and cardiac output. The activation of muscle spindles in forelimb muscles also enhances minute ventilation and respiratory frequency in resting humans (Jammes et al, 1981(Jammes et al, & 1984.…”

Section: Introductionmentioning

confidence: 99%

Acute Hypoxemia Depresses the Cardiorespiratory Response During Phase I Constant Load Exercise and Unloaded Cycling

Zattara‐Hartmann¹,

Jammes²

1996

Archives of Physiology and Biochemistry

View full text Add to dashboard Cite

The effects of acute inhalation of hypoxic gas mixtures on minute ventilation (VE), respiratory frequency (fR) and heart rate (HR) were studied in healthy subjects executing constant-load 100 W and 150 W hindlimb exercises (protocol 1) or unloaded (0 W) cycling (protocol 2). Attention was focussed on early changes in variables during phase I of constant load exercise, a period where neurogenic afferents from working muscles play a key role in adaptative cardiorespiratory response as they did also during 0 W cycling. In protocol 1, a 15% O2 gas mixture was used while in protocol 2, 15% and 10% O2 mixtures were tested. Compared to the variations of cardiorespiratory variables measured during room air breathing (normoxia), hypoxemia significantly and markedly depressed the rates of VE and fR changes during phase I exercise but did not affect the changes in HR. Reduced phase I ventilatory response was not accompanied by significant variations in rest values of PaCO2 and pHa associated with the response to hypoxia. The cardiorespiratory response to 0 W cycling was also lowered under hypoxemic conditions, the magnitude of VE and HR changes being inversely proportional to the fall in PaO2 level. Based on electrophysiological animal observations, the present results may be interpreted in terms of inhibitory influences of hypoxemia on proprioceptive muscle afferents.

show abstract

“…In fact, Leitner and Dejours (1971) have demonstrated that a signi®cant increase in ventilation occurred by vibrating triceps surae muscles of the hindlimbs which would have excited mainly the primary nerve endings from muscle spindles. Gautier et al (1969) have reported that a succinylcholine-induced excitation of muscle spindles in cats produced increases in HR and pulmonary ventilation. Thus, aerent inputs arising from muscle proprioceptors of the leg was considered to evoke the ventilatory excitation as well as the activation of sympathetic nerve activity.…”

Section: Discussionmentioning

confidence: 98%

Dynamics of human cardiorespiratory responses to standing on one leg with eyes closed

Kita

Sakamoto

Ryushi

et al. 1997

European Journal of Applied Physiology and Occupational Physiol

View full text Add to dashboard Cite

The postural control system has been extensively studied in terms of somatic motor function but little is known about its connection with human autonomic function. The purpose of this study was to determine the cardiorespiratory changes in response to the 1-min balance test that was performed by standing on one leg with eyes closed (SOLEC) or eyes open (SOLEO) in 12 healthy young women [mean age 20.7 (SD 3.3) years]. Heart rate (HR), respiratory rate (RR), duration of inspiration and expiration, tidal volume (VT), and oxygen uptake (VO2) were measured during the test. The SOLEC test produced rapid increases in HR at the onset. There were significant increases in HR later during the test (P < 0.05). Metabolic rate (VO2) showed a gradual increase during the SOLEC test, indicating that the late responses could have been partly due to metabolic changes. The RR increased significantly at the onset of the test (P < 0.05), and remained elevated until the end of the test. The early responses were considered to be mediated neurally through the postural control system which receives the afferent inputs arising from the vestibular system and from muscle proprioceptors of the leg. In contrast, SOLEO caused small insignificant changes in HR, RR, VT and VO2, suggesting that a visual input is essential for balancing a postural change. The SOLEC test may have potential as a test of autonomic function.

show abstract

Ventilatory response to muscle spindle stimulation by succinylcholine in cats

Cited by 23 publications

References 13 publications

Sensing vascular distension in skeletal muscle by slow conducting afferent fibers: neurophysiological basis and implication for respiratory control

Sensing vascular distension in skeletal muscle by slow conducting afferent fibers: neurophysiological basis and implication for respiratory control

Acute Hypoxemia Depresses the Cardiorespiratory Response During Phase I Constant Load Exercise and Unloaded Cycling

Dynamics of human cardiorespiratory responses to standing on one leg with eyes closed

Contact Info

Product

Resources

About