1985
DOI: 10.1097/00000542-198506000-00008
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Ventilatory Responses to Acute Metabolic Acidemia in Humans Awake, Sedated, and Anesthetized with Halothane

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Cited by 37 publications
(24 citation statements)
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“…A recent observation [4] adds further to the debate. Halothane at 0.1 MAC did not significantly reduce the hypercapnic ventilatory response [4], which agrees with Knill et al [1,2] but is in contrast to Dahan et al's results [3].…”
supporting
confidence: 85%
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“…A recent observation [4] adds further to the debate. Halothane at 0.1 MAC did not significantly reduce the hypercapnic ventilatory response [4], which agrees with Knill et al [1,2] but is in contrast to Dahan et al's results [3].…”
supporting
confidence: 85%
“…Later authors disputed these observations and reported a dose-dependent reduction in the ventilation-CO 2 slope (for doses in the range of £ 0.2 MAC) [3]. One of the suggested reasons for the difference in results was that Knill et al [1,2] had used Read's rebreathing method to induce hypercapnia (the end-tidal PCO 2 rises progressively over several minutes as air, or oxygenenriched air, is rebreathed from a large bag), whereas Dahan et al [3] used step hypercapnia (end-tidal PCO 2 rises rapidly to the desired level within seconds). Subsequent studies have explored these observations [4][5][6][7][8][9][10][11][12][13][14].…”
mentioning
confidence: 99%
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“…In an isocapnic comparison such as the one being discussed, the VE-pHa slope is probably determined largely by the peripheral chemoreflex sensitivity. This is because the central chemoreflex has a low or absent sensitivity to arterial H+ changes of the magnitude and duration employed in the current study (Mitchell & Singer, 1965;Knill & Clement, 1985;see Clement et al (1992) V02, rate of 0 consumption; VC, 2 rate of CO2 production.…”
Section: Vf-ph Slopesmentioning
confidence: 83%