Ventilatory Volumes, Flow Rates, Transfer Factor and Its Components (Membrane Component, Capillary Volume) in Obese Adults and Children

Bosisio, E; Sergi, M.; Natale, B. Di; Chiumello, G

doi:10.1159/000194638

Cited by 34 publications

(25 citation statements)

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“…However, studies on children have found conflicting results. Lung compliance, vital capacity, and residual volume in obese children are similar to those of non-obese children in the majority of the studies (23)(24)(25)(26) have confirmed reduced functional residual capacity and static lung volumes (12)(13)(14). The impact of obesity on respiratory functions in overweight, obese and morbidly obese children has not yet been fully determined.…”

Section: Discussionmentioning

confidence: 87%

The Effect of Obesity Degree on Childhood Pulmonary Function Tests

Torun¹,

Çakır²,

Özgüç³

et al. 2014

Balkan Med J

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Background:Childhood obesity has become a global epidemic. It is related to several chronic diseases such as essential hypertension, type 2 diabetes mellitus, and renal disease. The relationship between the degree of obesity and lung functions is well defined in adults, but limited information is available about the childhood period. Aims: This study aims to determine the impact of the degree of obesity on the pulmonary functions of school children and adolescents. Study Design: Cross sectional study. Methods: Included in the study were a total of 170 school children and adolescents (9-17 years old) referred to our paediatric outpatient clinic. Of these subjects, 42 were lean and non-obese (BMI % <85), 30 subjects were overweight (BMI % ˃85, <95), 34 subjects were obese (BMI % ˃95, <97), and 64 subjects were morbidly obese (BMI % ˃97). Anthropometric measurements were taken and spirometry was performed on all subjects. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV 1 ), forced vital capacity ) and peak expiratory flow (PEF) were used to measure the ventilatory functions for all the subjects. Results: The groups showed no significant differences in age or gender. Despite no statistically significant differences in FEV 1 , FVC, or FEV 1 /FVC, there were significant reductions in PEF (p<0.001) and FEV 25-75 (p<0.001) in the overweight, obese and morbidly obese subjects, when compared with those who were non-obese. Conclusion: Overweight, obese and morbidly obese children have no obstructive abnormalities compared with healthy lean subjects. (Balkan Med J 2014;31:235-8).

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Section: Discussionmentioning

confidence: 87%

The Effect of Obesity Degree on Childhood Pulmonary Function Tests

Torun¹,

Çakır²,

Özgüç³

et al. 2014

Balkan Med J

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“…None had evidence of cardiopulmonary disease on history review or clinical examination. Their median age was 12 years (interquartile range (IQR) [10][11][12][13][14] and the median BMI and standard deviation score were 30.1 kg/m 2 (IQR 27.2-32.8) and 2.42 (IQR 2.13-2.66) respectively. Table 1 shows the demographic characteristics and the results of spirometric, lung volume testing, diffusion capacity, and DEXA scan of the study population.…”

Section: Resultsmentioning

confidence: 99%

The effects of obesity on pulmonary function

2003

Archives of Disease in Childhood

200

138

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Aims: (1) To determine the predominant pulmonary function abnormality in our population of obese children; and (2) to assess the correlation between the severity of lung function impairment and the degree of obesity as assessed by dual energy x ray absorptiometry (DEXA). Methods: Sixty four obese patients underwent physical examination, standardised pulmonary function tests (spirometry, lung volumes, and single breath diffusion capacity for carbon monoxide), and DEXA scan measurements. The trunk and subtotal (total − head) body fat mass were used as surrogate index of body adiposity. Results: Sixteen girls and 48 boys with median age and body mass index (BMI) of 12 years (interquartile range (IQR): 10-14) and 30.1 kg/m 2 (IQR: 27.2-32.8) respectively were studied. None of the patients had clinical evidence of cardiopulmonary disease. Reduction in functional residual capacity (median FRC 93% predicted, IQR: 68.5-116.5%) and impairment of diffusion capacity (median DLco 83.5% predicted, IQR: 70.0-100.7%) were the most common abnormalities in our cohort, being observed in 30 (46%) and 21 (33%) patients respectively. Obstructive ventilatory impairment was found in three patients. There was significant negative correlation between the degree of reduction of FRC but not DLco with DEXA scan measurements, but such a relation was not found when BMI was used as the indicator of obesity. Conclusion: Reduction in FRC and diffusion impairment were the commonest abnormalities found in our cohort of obese patients. Reduction in static lung volume was correlated with the degree of obesity.

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“…[41][42][43] These observations have led to the hypothesis that obesity-related chest wall restriction and the resultant breathing at low lung volume leads to airway obstruction, reactivity, and an asthma-like phenotype. These physiologic characteristics seen in some obese adults appear less commonly in children, [44][45][46][47][48][49] perhaps due to a reduced duration of obesity in children relative to adults. Obesity's effects on airway mechanics and airway reactivity among asthmatic children require more investigation.…”

Section: If Obesity Leads To Asthma What Is the Mechanism?mentioning

confidence: 99%

Obesity, Nutrition, and Asthma in Children

Lang

2012

Pediatric Allergy, Immunology, and Pulmonology

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Ventilatory Volumes, Flow Rates, Transfer Factor and Its Components (Membrane Component, Capillary Volume) in Obese Adults and Children

Cited by 34 publications

References 1 publication

The Effect of Obesity Degree on Childhood Pulmonary Function Tests

The Effect of Obesity Degree on Childhood Pulmonary Function Tests

The effects of obesity on pulmonary function

Obesity, Nutrition, and Asthma in Children

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