Ventral nucleus of the lateral lemniscus in guinea pigs: Cytoarchitecture and inputs from the cochlear nucleus

Schofield, Brett R.; Cant, Nell B.

doi:10.1002/(sici)1096-9861(19970317)379:3<363::aid-cne4>3.0.co;2-1

Cited by 84 publications

(99 citation statements)

References 81 publications

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“…Indeed, the projection of the onset cells of Friauf and Ostwald is reminiscent of those of octopus cells described by Adams (1979). Octopus cells have been reported to show onset-type responses (Godfrey et al 1975;Rhode et al 1983) and to project to the ventral nucleus of the lateral lemniscus (Schofield and Cant 1997).…”

Section: Projection To the Contralateral Dcnmentioning

confidence: 89%

Onset Neurones in the Anteroventral Cochlear Nucleus Project to the Dorsal Cochlear Nucleus

Arnott

Wallace

Shackleton

et al. 2004

JARO

113

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Considerable circumstantial evidence suggests that cells in the ventral cochlear nucleus, that respond predominantly to the onset of pure tone bursts, have a stellate morphology and project, among other places, to the dorsal cochlear nucleus. The characteristics of such cells make them leading candidates for providing the so-called ''wideband inhibitory input'' which is an essential part of the processing machinery of the dorsal cochlear nucleus. Here we use juxtacellular labeling with biocytin to demonstrate directly that large stellate cells, with onset responses, terminate profusely in the dorsal cochlear nucleus. They also provide widespread local innervation of the anteroventral cochlear nucleus and a small innervation of the posteroventral cochlear nucleus. In addition, some onset cells project to the contralateral dorsal cochlear nucleus.

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Section: Projection To the Contralateral Dcnmentioning

confidence: 89%

Onset Neurones in the Anteroventral Cochlear Nucleus Project to the Dorsal Cochlear Nucleus

Arnott

Wallace

Shackleton

et al. 2004

JARO

113

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“…They respond strongly to modulated stimuli and thus mark temporal features of sounds, such as the syllables of speech. Octopus cells project to an area of the contralateral ventral nucleus of the lateral lemniscus (VnLL) that also contains onset neurons (32)(33)(34); the VnLL, in turn, projects to the IC, often making inhibitory terminals (35). Both sets of onset cells have properties consistent with a population marker for stimulus onsets.…”

Section: Discussionmentioning

confidence: 99%

First-spike latency information in single neurons increases when referenced to population onset

Chase

Young

2007

Proc. Natl. Acad. Sci. U.S.A.

168

147

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It is well known that many stimulus parameters, such as sound location in the auditory system or contrast in the visual system, can modulate the timing of the first spike in sensory neurons. Could first-spike latency be a candidate neural code? Most studies measuring first-spike latency information assume that the brain has an independent reference for stimulus onset from which to extract latency. This assumption creates an obvious confound that casts doubt on the feasibility of first-spike latency codes. If latency is measured relative to an internal reference of stimulus onset calculated from the responses of the neural population, the information conveyed by the latency of single neurons might decrease because of correlated changes in latency across the population. Here we assess the effects of a realistic model of stimulus onset detection on the first-spike latency information conveyed by single neurons in the auditory system. Contrary to expectation, we find that on average, the information contained in single neurons does not decrease; in fact, the majority of neurons show a slight increase in the information conveyed by latency referenced to a population onset. Our results show that first-spike latency codes are a feasible mechanism for information transfer even when biologically plausible estimates of stimulus onset are taken into account.coding ͉ inferior colliculus ͉ mutual information ͉ sound localization T he first-spike latency has been shown to carry information in several sensory modalities, including the auditory (1, 2), visual (3, 4), and somatosensory (5-7) systems. However, most studies quantifying first-spike latency information assume that the brain has an independent reference for stimulus onset from which to extract latency. In the majority of situations, this independent onset reference does not exist; the need for a timing reference has caused some to question the ultimate feasibility of first-spike latency codes (8).A number of authors have suggested possible alternative latency measures (1,3,5,6), but few have actually compared the information contained in different onset references. Stecker and Middlebrooks (9) computed the information contained in the relative spike timing of pairs of simultaneously recorded neurons in auditory cortex, and Furukawa et al. (10) compared the median errors from neural-network estimates of location with similar data. In both cases, performance with relative-latency measures was worse than with an independent onset reference, presumably because using a single neuron as the onset reference increases the overall measurement jitter. Other authors (11-13) have investigated rank order codes, where information is conveyed by the relative order in which neurons fire. Jenison (14) has shown by using modeling and maximum likelihood techniques that correlation can, in principle, increase the information available in first-spike latency, provided the decoder knows the correlation structure. However, such location estimates get noisier when stimulus onset is estimate...

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“…The VNLL receives direct projections primarily from the contralateral VCN and, to a lesser extent, from the ipsilateral MNTB. In addition, there are ipsilateral projections from the lateral nucleus of the trapezoidal body (LNTB) and the ventral nucleus of the trapezoid body (VNTB) (Adams 1997;Friauf and Ostwald 1988;Glendenning et al 1981;Schofield and Cant 1997;Suneja et al 1995). Excitatory projections from the VCN would be expected to impose their response patterns on target neurons in the VNLL.…”

Section: Intrinsic and Synaptic Basis Of Temporal Response Characterimentioning

confidence: 99%

“…The VNLL receives major afferent projections from the contralateral ventral cochlear nucleus (VCN), the ipsilateral medial nucleus of the trapezoid body (MNTB), and other ipsilateral periolivary nuclei, but does not receive projections from the medial or lateral superior olives, two nuclei that have been shown to be important for binaural processing in the auditory system (Adams 1997; Friauf and Ostwald 1988;Glendenning et al 1981;Huffman and Covey 1995;Oertel and Wickesberg 2002;Schofield and Cant 1997;Smith et al 1991Smith et al , 1993aSpangler et al 1985;Vater et al 1997;Warr and Beck 1996;Zook and Casseday 1985). For this reason, the VNLL is considered to be a nucleus dedicated primarily to processing information about the temporal or spectral quality of auditory stimuli rather than the binaural disparities that provide cues for the localization of sounds in space (Covey and Casseday 1991;Oertel and Wickesberg 2002).…”

Section: Introductionmentioning

confidence: 99%

Responses of Neurons in the Rat's Ventral Nucleus of the Lateral Lemniscus to Monaural and Binaural Tone Bursts

Zhang

Kelly²

2006

Journal of Neurophysiology

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Zhang, Huiming and Jack B. Kelly. Responses of neurons in the rat's ventral nucleus of the lateral lemniscus to monaural and binaural tone bursts. J Neurophysiol 95: 2501-2512, 2006. First published January 4, 2006 doi:10.1152/jn.01215.2005. Responses to monaural and binaural tone bursts were recorded from neurons in the rat's ventral nucleus of the lateral lemniscus (VNLL). Most of the neurons (55%) had V-or U-shaped frequency-tuning curves with a single clearly defined characteristic frequency (CF). However, many neurons had more complex, multipeaked tuning curves (37%), or other patterns (8%). Temporal firing patterns included both onset and sustained responses to contralateral tone bursts. Onset and sustained responses were distributed along the dorsoventral length of VNLL with no indication of segregation into different regions. Onset neurons had shorter average first-spike latencies than neurons with sustained responses (means, 8.3 vs. 14.8 ms). They also had less jitter, as reflected in the SD of first-spike latencies, than neurons with sustained responses (means, 0.59 and 4.2 ms, respectively). The extent of jitter decreased with an increase in stimulus intensity for neurons with sustained responses, but remained unchanged for onset neurons tested over the same range. Many neurons had binaural responses, primarily of the excitatory/inhibitory (EI) type, widely distributed along the dorsoventral extent of VNLL. Local application of the AMPA receptor antagonist NBQX reduced excitatory responses, indicating that responses were dependent on synaptic activity and not recorded from passing fibers. The results show that many neurons in VNLL have a precision of timing that is well suited for processing auditory temporal information. In the rat, these neurons are intermingled among cells with less precise temporal response features and include cells with binaural as well as monaural responses. I N T R O D U C T I O NThe ventral nucleus of the lateral lemniscus (VNLL), a prominent structure in the auditory brain stem, consists of a discrete collection of neurons located along the pathway from cochlear nucleus to inferior colliculus. The VNLL receives major afferent projections from the contralateral ventral cochlear nucleus (VCN), the ipsilateral medial nucleus of the trapezoid body (MNTB), and other ipsilateral periolivary nuclei, but does not receive projections from the medial or lateral superior olives, two nuclei that have been shown to be important for binaural processing in the auditory system

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Ventral nucleus of the lateral lemniscus in guinea pigs: Cytoarchitecture and inputs from the cochlear nucleus

Cited by 84 publications

References 81 publications

Onset Neurones in the Anteroventral Cochlear Nucleus Project to the Dorsal Cochlear Nucleus

Onset Neurones in the Anteroventral Cochlear Nucleus Project to the Dorsal Cochlear Nucleus

First-spike latency information in single neurons increases when referenced to population onset

Responses of Neurons in the Rat's Ventral Nucleus of the Lateral Lemniscus to Monaural and Binaural Tone Bursts

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