Ventral Striatal Activation During Reward Anticipation Correlates with Impulsivity in Alcoholics

Beck, Anne; Schlagenhauf, Florian; Wüstenberg, Torsten; Hein, Jakob; Kienast, Thorsten; Kahnt, Thorsten; Schmack, Katharina; Hägele, Claudia; Knutson, Brian; Heinz, Andreas; Wrase, Jana

doi:10.1016/j.biopsych.2009.04.035

Cited by 420 publications

(261 citation statements)

References 67 publications

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“…Previous findings of abnormal ventral-striatal activity in adolescent/young adult FHP or alcohol-dependent individuals were often associated with high impulsivity or alcohol use (Beck et al, 2009;Bjork et al, 2008a;Bjork et al, 2008b;Heitzeg et al, 2008;Heitzeg et al, 2010;Wrase et al, 2007). The lack of ventral-striatal findings in this sample may have been due to the FHP and FHN groups' similar impulsivity and alcohol use levels.…”

Section: Lack Of Family History Of Alcoholism Effects In Ventral-stricontrasting

confidence: 52%

Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism

DeVito

Meda

Jiantonio

et al. 2013

Neuropsychopharmacol

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Individuals family-history positive (FHP) for alcoholism have increased risk for the disorder, which may be mediated by intermediate behavioral traits such as impulsivity. Given the sex differences in the risk for and clinical presentation of addictive disorders, risk for addiction may be differentially mediated by impulsivity within FHP males and females. FHP (N ¼ 28) and family-history negative (FHN, N ¼ 31) healthy, non-substance-abusing adults completed an fMRI Go/No-Go task and were assessed on impulsivity and alcohol use. Effects of family history and sex were investigated as were associations between neural correlates of impulse control and out-ofscanner measures of impulsivity and alcohol use. FHP individuals showed greater activation in the left anterior insula and inferior frontal gyrus during successful inhibitions, an effect that was driven primarily by FHP males. Higher self-reported impulsivity and behavioral discounting impulsivity, but not alcohol use measures, were associated with greater BOLD signal in the region that differentiated the FHP and FHN groups. Impulsivity factors were associated with alcohol use measures across the FHP and FHN groups. These findings are consistent with increased risk for addiction among FHP individuals being conferred through disrupted function within neural systems important for impulse control. Keywords: impulsivity; family history of alcoholism; insula; inferior frontal gyrus (IFG); addiction; sex differences. INTRODUCTIONAlcohol use disorders (AUDs) are prevalent and associated with detrimental health and societal outcomes (Li, 2008). Individuals with a family history of alcoholism (familyhistory positive (FHP)) have increased risk for alcoholism driven by genetic and environmental factors (Lieb et al, 2002;Slutske et al, 2002). Healthy FHPs model addiction vulnerability without confounding effects of excess alcohol on cognition and brain function.Increased AUD risk among FHPs may be conferred via heritable impulsive tendencies (Dick et al, 2010;Tessner and Hill, 2010). Impulsivity is a multi-factorial construct, where distinct sub-components appear to have differential neural bases and relationships with addiction (de Wit, 2009;Lejuez et al, 2010;Rogers et al, 2010). Aspects of impulsivity may both predispose to and be exacerbated by addictive behaviors. Impulsivity predicts development of AUDs; is higher in FHPs with more alcohol-dependent relatives (ie higher family-history load); and partially mediates the relationship between FHP and alcohol and substance use disorder (for review, see de Wit, 2009;Dick et al, 2010;Lejuez et al, 2010;Verdejo-Garcia et al, 2008). Other less well-studied impulsivity-related constructs (eg, sensationseeking, risk-taking, compulsivity, behavioural activation/ inhibition, reward/punishment sensitivity) have been related to addiction vulnerability, and addictions therefore warrant consideration (eg, Meda et al, 2009).Sex differences are important to consider as they are observable for rates, clinical presentation, and health cons...

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Section: Lack Of Family History Of Alcoholism Effects In Ventral-stricontrasting

confidence: 52%

Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism

DeVito

Meda

Jiantonio

et al. 2013

Neuropsychopharmacol

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“…This in turn means that sudden, unexpected presentation of such cues should elicit greater dopaminergic transients. PET studies measuring released dopamine with raclopride displacement (Kalivas and Volkow, 2005;Volkow et al, 2006;Boileau et al, 2007) and fMRI studies measuring responses to drug-associated cues (Grüsser et al, 2004;Wrase et al, 2007;Beck et al, 2009) both clearly support this prediction (though see Wilson et al 2004 for a discussion of how these relate to craving).…”

Section: Individual Variability In Addiction Vulnerabilitymentioning

confidence: 93%

The role of learning-related dopamine signals in addiction vulnerability

Huys

Tobler

Hasler

et al. 2014

Progress in Brain Research

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Psychostimulants such as methylphenidate (MPH) and antidepressants such as fluoxetine (FLX) are widely used in the treatment of various mental disorders or as cognitive enhancers. These medications are often combined, for example, to treat comorbid disorders. There is a considerable body of evidence from animal models indicating that individually these psychotropic medications can have detrimental effects on the brain and behavior, especially when given during sensitive periods of brain development. However, almost no studies investigate possible interactions between these drugs. This is surprising given that their combined neurochemical effects (enhanced dopamine and serotonin neurotransmission) mimic some effects of illicit drugs such as cocaine and amphetamine. Here, we summarize recent studies in juvenile rats on the molecular effects in the mid-and forebrain and associated behavioral changes, after such combination treatments. Our findings indicate that these combined MPH + FLX treatments can produce similar molecular changes as seen after cocaine exposure while inducing behavioral changes indicative of dysregulated mood and motivation, effects that often endure into adulthood. Tables: 2 References: 254 ABSTRACT Dopaminergic signals play a mathematically precise role in reward-related learning, and variations in dopaminergic signalling have been implicated in vulnerability to addiction. Here, we provide a detailed overview of the relationship between theoretical, mathematical and experimental accounts of phasic dopamine signalling, with implications for the role of learning-related dopamine signalling in addiction and related disorders. We describe the theoretical and behavioural characteristics of model-free learning based on errors in the prediction of reward, including step-by-step explanations of the underlying equations. We then use recent insights from an animal model that highlights individual variation in learning during a Pavlovian conditioning paradigm to describe overlapping aspects of incentive salience attribution and model-free learning. We argue that this provides a computationally coherent account of some features of addiction. CONTENTS

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“…Therefore, a more detailed understanding of the (neural) mechanisms underlying the effects of impulsivity on treatment outcomes is needed, as this may lead to novel interventions aimed at minimizing these negative effects and may facilitate treatment responding in these subjects. One neural mechanism potentially linking impulsivity with poor treatment outcomes is a motivational deficit associated with dopamine dysfunction: pronounced disruptions in dopamine functioning associated with impulsivity may produce difficulties in attributing salience to novel reward-indicating stimuli (Beck et al, 2009;Martinez et al, 2011) and affect the ability of the individual to successfully modify behavior in the face of enriched rewarding contingencies (Goto & Grace, 2008). Speculatively, pharmacological interventions aimed at restoring dopamine functioning might facilitate CM-responding in these individuals by targeting neurobiological bottom-up processes associated with reward processing and salience attribution .…”

Section: Treatment Modification For High-impulsive Substance Abusersmentioning

confidence: 99%

Impulsivity as a vulnerability factor for poor addiction treatment outcomes: A review of neurocognitive findings among individuals with substance use disorders

Stevens

Verdejo-García

Goudriaan

et al. 2014

Journal of Substance Abuse Treatment

274

178

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With the current review, we explore the hypothesis that individual differences in neurocognitive aspects of impulsivity (i.e., cognitive and motor disinhibition, delay discounting and impulsive decision-making) among individuals with a substance use disorder are linked to unfavorable addiction treatment outcomes, including high drop-out rates and difficulties in achieving and maintaining abstinence. A systematic review of the literature was carried out using PubMed, PsycINFO and Web of Knowledge searches. Twenty-five unique empirical papers were identified and findings were considered in relation to the different impulsivity dimensions. Although conceptual/methodological heterogeneity and lack of replication are key limitations of studies in this area, findings speak for a prominent role of cognitive disinhibition, delay discounting and impulsive decision-making in the ability to successfully achieve and maintain abstinence during and following addiction treatment. In contrast, indices of motor disinhibition appear to be unrelated to abstinence levels. Whereas the relationship between impulsivity and treatment retention needs to be examined more extensively, preliminary evidence suggests that impulsive/risky decision-making is unrelated to premature treatment drop-out among individuals with a substance use disorder. The reviewed findings are discussed in terms of their clinical implications.

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Ventral Striatal Activation During Reward Anticipation Correlates with Impulsivity in Alcoholics

Cited by 420 publications

References 67 publications

Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism

Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism

The role of learning-related dopamine signals in addiction vulnerability

Impulsivity as a vulnerability factor for poor addiction treatment outcomes: A review of neurocognitive findings among individuals with substance use disorders

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