Ventral Striatum/Nucleus Accumbens Activation to Smoking-Related Pictorial Cues in Smokers and Nonsmokers: A Functional Magnetic Resonance Imaging Study

David, Sean P.; Munafò, Marcus R.; Johansen‐Berg, Heidi; Smith, Stephen M.; Rogers, Robert D.; Matthews, Paul M.

doi:10.1016/j.biopsych.2005.04.028

Cited by 261 publications

(253 citation statements)

References 59 publications

Supporting

Mentioning

227

Contrasting

Unclassified

Order By: Relevance

“…22,58 The ventral striatum and prefrontal cortex appear to have integrated and differentiated roles in the process of reward signalling and aversive affects of nicotine administration and withdrawal. [59][60][61][62] However, whether or not the differentiation in processing rewarding and aversive drug experiences varies among dopamine receptor subtype, or how this might translate to lack of apparent pharmacogenetic effects on smoking cessation of DRD4 genotype compared with DRD2 genotype, would require further study.…”

Section: Discussionmentioning

confidence: 99%

Genetic variation in the dopamine D4 receptor (DRD4) gene and smoking cessation: follow-up of a randomised clinical trial of transdermal nicotine patch

et al. 2007

View full text Add to dashboard Cite

Smokers of European ancestry (n ¼ 720) who participated in a double-blind, randomised, placebo-controlled trial of transdermal nicotine replacement therapy, were genotyped for two functional polymorphisms (variable number of tandem repeats (VNTR) and a C to T transition at position -521 (C-521T)) in the dopamine D4 receptor gene (DRD4) gene. Logistic regression models of abstinence at 12-and 26-week follow-ups were carried out separately for each polymorphism. For the DRD4 VNTR models, the main effect of treatment was significant at both 12-week (P ¼ 0.001) and 26-week (P ¼ 0.006) follow-ups, indicating an increased likelihood of successful cessation on active nicotine replacement therapy transdermal patch relative to placebo. The main effect of DRD4 VNTR genotype was associated with abstinence at 12-week follow-up (P ¼ 0.034), with possession of one or more copies of the long allele associated with reduced likelihood of cessation (17 vs 23%), but this effect was not observed at 26-week follow-up. For the DRD4 C-521T models, no main effect or interaction terms involving genotype were retained in the models at either 12-or 26-week follow-up. These data are consistent with observations from studies of the DRD2 gene that genetic variants related to relatively decreased dopaminergic tone in the mesocorticolimbic system are associated with increased risk for relapse to smoking following a cessation attempt.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetic variation in the dopamine D4 receptor (DRD4) gene and smoking cessation: follow-up of a randomised clinical trial of transdermal nicotine patch

et al. 2007

View full text Add to dashboard Cite

show abstract

“…The vSTR, which includes the nucleus accumbens, is sensitive to both reward magnitude (Galvan et al, 2005) and probability (Pagnoni et al, 2002) and has been shown to be active in response to drug cues (David et al, 2005;Kilts et al, 2001). At the same time, another event-related study observed decreased cue reactivity in the nucleus accumbens of smokers (Due et al, 2002).…”

Section: Cravingmentioning

confidence: 99%

Individual Differences in Nicotine Dependence, Withdrawal Symptoms, and Sex Predict Transient fMRI-BOLD Responses to Smoking Cues

McClernon

Kozink

Rose

2007

Neuropsychopharmacol

191

146

View full text Add to dashboard Cite

Exposure to smoking cues increases craving for cigarettes and can precipitate relapse. Whereas brain imaging studies have identified a distinct network of brain regions subserving the processing of smoking cues, little is known about the influence of individual difference factors and withdrawal symptoms on brain cue reactivity. Multiple regression analysis was used to evaluate relations between individual difference factors and withdrawal symptoms and event-related blood oxygen level-dependent responses to visual smoking cues in a sample of 30 smokers. Predictors were self-report nicotine dependence (Fagerströ m test of nicotine dependence, FTND), prescan withdrawal symptoms (craving and negative affect), and sex. The unique variance of each predictor was examined after controlling for each of the others. Positive associations were observed between FTND and reactivity to cues in right anterior cingulate and orbitofrontal cortex (OFC) whereas negative associations were observed between prescan craving and reactivity in ventral striatum. Higher negative affect or being male was associated with greater reactivity in left hippocampus and left OFC. Women exhibited greater cue reactivity than men in regions including the cuneus and left superior temporal gyrus. Individual difference factors and withdrawal symptoms were uniquely associated with brain reactivity to smoking cues in regions subserving reward, affect, attention, motivation, and memory. These findings provide further evidence that reactivity to conditioned drug cues is multiply determined and suggest that smoking cessation treatments designed to reduce cue reactivity focus on each of these variables.

show abstract

“…Insulae are important in mediating autonomic responses to drugs of abuse and their predictors and thus were examined in the analysis (Bechara et al, 2000;Garavan et al, 2000). Lastly, we predicted that smoking cues would activate the fusiform gyrus, as it plays a role in attention, and has been activated in previous nicotine cue reactivity studies (David et al, 2005;Due et al, 2002;Wilson et al, 2005). We hypothesized that increases in perfusion in ventral medial prefrontal and deep limbic structures (amygdala, insula, and ventral striatum), regions important in mediating responses to drug cues, would correlate with subjective craving scores.…”

Section: A Priori Cns Regions Of Interestmentioning

confidence: 99%

Limbic Activation to Cigarette Smoking Cues Independent of Nicotine Withdrawal: A Perfusion fMRI Study

Franklin

wang

Wang

et al. 2007

Neuropsychopharmacol

328

282

View full text Add to dashboard Cite

Exposure to cigarette smoking cues can trigger physiological arousal and desire to smoke. The brain substrates of smoking cue-induced craving (CIC) are beginning to be elucidated; however, it has been difficult to study this state independent of the potential contributions of pharmacological withdrawal from nicotine. Pharmacological withdrawal itself may have substantial effects on brain activation to cues, either by obscuring or enhancing it, and as CIC is not reduced by nicotine replacement strategies, its neuro-anatomical substrates may differ. Thus, characterizing CIC is critical for developing effective interventions. This study used arterial spin-labeled (ASL) perfusion fMRI, and newly developed and highly appetitive, explicit smoking stimuli, to examine neural activity to cigarette CIC in an original experimental design that strongly minimizes contributions from pharmacological withdrawal. Twenty-one smokers (12 females) completed smoking and nonsmoking cue fMRI sessions. Craving self-reports were collected before and after each session. SPM2 software was employed to analyze data. Blood flow (perfusion) in a priori-selected regions was greater during exposure to smoking stimuli compared to nonsmoking stimuli (po0.01; corrected) in ventral striatum, amygdala, orbitofrontal cortex, hippocampus, medial thalamus, and left insula. Perfusion positively correlated with intensity of cigarette CIC in both the dorsolateral prefrontal cortex (r 2 ¼ 0.54) and posterior cingulate (r 2 ¼ 0.53). This pattern of activation that includes the ventral striatum, a critical reward substrate, and the interconnected amygdala, cingulate and OFC, is consistent with decades of animal research on the neural correlates of conditioned drug reward. Keywords: cigarette smoking; craving; neuroimaging; ventral striatum; amygdala; DLPFC INTRODUCTION RationaleBoth nicotine and conditioned cues (reminders) maintain cigarette smoking and lead to relapse (Henningfield and Goldberg, 1983;Rose, 2006). Thus, effective smoking cessation treatments should address both factors. Nicotine replacement therapy (NRT) and bupropion are both effective at ameliorating nicotine withdrawal-induced craving, but neither block the craving elicited by learned associations formed between environmental cues and nicotine (Teneggi and Tiffany, 2002;Robinson and Berridge, 1993;Wise, 1988;Hughes et al, 1999;Hurt et al, 1997;Jorenby et al, 1999). Currently, medications that unequivocally prevent or reduce cue-induced craving (CIC) are not available. Further understanding of the underlying neurobiology of CIC would facilitate the development of effective therapies and improve the currently low (10-20% at 6 months to a year) success rates associated with current smoking interventions West et al, 2001). Thus, a major goal of this work is to examine the element of neurobiology underlying CIC distinct from that observed in CIC studies associated with nicotine withdrawal.Craving generated by drug cues may accrue slowly over time, recruiting supplementary neural substrates as...

show abstract

Ventral Striatum/Nucleus Accumbens Activation to Smoking-Related Pictorial Cues in Smokers and Nonsmokers: A Functional Magnetic Resonance Imaging Study

Abstract: Background-Converging evidence from several theories of the development of incentivesensitization to smoking-related environmental stimuli suggests that the ventral striatum plays an important role in the processing of smoking-related cue reactivity.

Cited by 261 publications

References 59 publications

Genetic variation in the dopamine D4 receptor (DRD4) gene and smoking cessation: follow-up of a randomised clinical trial of transdermal nicotine patch

Genetic variation in the dopamine D4 receptor (DRD4) gene and smoking cessation: follow-up of a randomised clinical trial of transdermal nicotine patch

Individual Differences in Nicotine Dependence, Withdrawal Symptoms, and Sex Predict Transient fMRI-BOLD Responses to Smoking Cues

Limbic Activation to Cigarette Smoking Cues Independent of Nicotine Withdrawal: A Perfusion fMRI Study

Contact Info

Product

Resources

About