Ventrally Located Cervical Dumbbell Ganglioneuroma Producing Spinal Cord Compression

Abstract

Ganglioneuroma is an uncommon benign tumor and arise from neural crest cells or sympathetic and peripheral nerves. A 13-year-old boy was referred to our institute and presented with three-day history of right upper extremity weakness associated with neck pain for nearly one month. Magnetic resonance imaging showed right side dumbbell shaped extramedullary lesion at the C2-3 level extending outside through neural foramen. Paraspinal and posterior neck mass, cafe au lait spot was identified. We performed surgical decompression of the spinal cord by resection of intradural portion mass. Histopathological diagnosis was ganglioneuroma.

Ganglioneuromas cervicales y su relación con la neurofibromatosis tipo 1

“…La primera descripción de un ganglioneuroma se realizó en 1870 4 , y aunque desde entonces se han descrito varios casos [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] , sigue tratándose de un tumor poco frecuente. Como su nombre indica, está compuesto por células ganglionares maduras 19 y asienta en aquellos tejidos derivados embriológicamente de la cresta neural, principalmente en el sistema nervioso autónomo.…”

Giant Ganglioneuroma of Thoracic Spine : A Case Report and Review of Literature

“…In the present case, there were dense adhesions of the tumor with the nerve roots at the foraminal portions, which were left undisturbed during dissection. GN generally has a favorable prognosis given its low metastatic potential 5) .…”

Bilateral Dumbbell Cervical Spinal Ganglioneuromas Associated with Neurofibromatosis Type 1

“…Of the 16 reported cases of CGN, 6 were associated with NF1 [3][4][5][6][7]. NF1 is a genetic disorder with varying neurocutaneous manifestations, including a predisposition for tumours.…”