Ventricular Activation Time as a Marker for Diastolic Dysfunction in Early Hypertension

Boles, Usama; Almuntaser, Ibrahim; Brown, Angie; Murphy, Ross; Mahmud, Azra; Feely, J.

doi:10.1038/ajh.2010.58

Cited by 33 publications

(15 citation statements)

References 23 publications

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“…VAT was defined as the average measurement from the onset of the Q wave to the peak of the R wave. The measurements from V6 were comparable with the mean value calculated from 12 leads as previously validated [ 18 ].…”

Section: Methodssupporting

confidence: 79%

Evaluation of the Tp-Te Interval, QTc and P-Wave Dispersion in Patients With Coronary Artery Ectasia

et al. 2017

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BackgroundCoronary artery ectasia (CAE) is defined as a diffuse dilatation of the diameter of the ectatic segment of the coronary artery, 1.5 times greater than that of the adjacent segment. The Tp-Te interval, P-wave and QTc dispersions are relatively new electrocardiographic markers associated with an increased risk of developing arrhythmias. Despite CAE increasing in prevalence in recent years, there is a sparsity of data available about its arrhythmogenic effect. The aim of the study was to evaluate QTc, P-wave dispersion and Tp-Te and Tp-Te/QT ratio in patients with CAE.MethodsA retrospective comparative study was designed for consecutive age- and sex-matched patients. Twenty patients with isolated CAE (group 1) and 20 control subjects (group 2), with normal coronary arteries, were included. All patients presented with chest pain and coronary angiogram was indicated. Outcome measures included Tp-Te interval, Tp-Te/QT ratio, QTc dispersion and P-wave dispersion. Measurement of electrocardiogram (ECG) parameters was conducted using standardized digital online software. Descriptive and inferential statistics were performed.ResultsMean Tp-Te (95.5 ± 9.01 ms) and Tp-Te/QT ratio (0.22 ± 0.02) were significantly prolonged in CAE group (Tp-Te: 84 ± 5.62 ms, P = 0.00009; Tp-Te/QT ratio: 0.20 ± 0.01, P = 0.00004). In addition, QTc (31.2 ± 3.71 ms) and P-wave dispersion (31.9 ± 5.46 ms) were significantly increased in comparison to the control group (QTc: 27.6 ± 2.82 ms, P = 0.00532 and 20 ± 3.77 ms, P = 0.00003 respectively). However, there was no difference in ventricular activation time (VAT) between groups.ConclusionsCAE ECGs were found to be associated with increased Tp-Te, Tp-Te/QT ratio, QTc intervals and P-wave dispersions. This may suggest that CAE existence has a pro-arrhythmogenic nature.

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Section: Methodssupporting

confidence: 79%

Evaluation of the Tp-Te Interval, QTc and P-Wave Dispersion in Patients With Coronary Artery Ectasia

et al. 2017

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“…ID measurement is a very simple ECG indicator for detection of diastolic dysfunction. In the study by Boles et al, ID prolongation was detected in the early stages of diastolic dysfunction [34]. It has been proven that the diastolic function was impaired initially in the presence of ischemia [35].…”

Section: Discussionmentioning

confidence: 93%

Effect of Coronary Slow Flow on Intrinsicoid Deflection of Qrs Complex

Seyis

2018

The American Journal of Cardiology

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Coronary slow ow is a rare, clinically important entity observed in acute coronary syndrome. e pathophysiological mechanism is not fully elucidated. We investigated patients with chest pain who had angiographic features consistent with the coronary slow ow. One hundred ten patients were included. Electrocardiography, echocardiography, and angiography results were retrospectively noted. e mean age was 56.4. Fifty-eight were male, and fty-two were female. e control group consisted of patients with normal angiography. Patients had higher diastolic blood pressure, lower mean ejection fraction, higher average left ventricular end-diastolic diameter, and higher mean left atrial size than the control group (p � 0.009, p � 0.017, p � 0.041, and p < 0.001, resp.). Patients had higher average V1 ID, V6 ID, P wave dispersion, TFC LAD, TFC Cx, TFC RCA, and TFC levels than the control group. A signi cant linear positive relationship was found between the V1 ID and the TFC LAD, TFC Cx, TFC RCA, and TFC; also between the V6 ID and the TFC LAD, TFC Cx, TFC RCA, and TFC. Angiographic and electrocardiographic features are suggestive and diagnostic for the coronary slow ow syndrome. Although when regarded as a benign condition, coronary slow ow should be diagnosed, followed up, and treated as many of laboratory features suggest ischemic events.

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“…LA volume was higher in those with prehypertension. QTD, Max LAV , and inter atrial dyssynchronywere correlated with most of parameters of LV remodeling and diastolic functionTable (4)(5) Correlations in high normal blood pressure group(group I): .001(HS) (S) significant: (P value < 0.05); (HS)highly significant (P value < 0.001); (NS)non-significant: (P value > 0.05).…”

Section: Result:-mentioning

confidence: 99%

Prehypertension ;The Point of Convergence or Divergence for End Organ Damage

MD¹,

MD²,

MD³

2016

IJAR

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Ventricular Activation Time as a Marker for Diastolic Dysfunction in Early Hypertension

Abstract: Prolongation of the VAT is associated with DD in patients with newly diagnosed untreated hypertension.

Cited by 33 publications

References 23 publications

Evaluation of the Tp-Te Interval, QTc and P-Wave Dispersion in Patients With Coronary Artery Ectasia

Evaluation of the Tp-Te Interval, QTc and P-Wave Dispersion in Patients With Coronary Artery Ectasia

Effect of Coronary Slow Flow on Intrinsicoid Deflection of Qrs Complex

Prehypertension ;The Point of Convergence or Divergence for End Organ Damage

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