Ventricular Effective Refraction Period and Ventricular Repolarization Analysis in Experimental Tachycardiomyopathy in Swine

Noszczyk-Nowak, Agnieszka; Pasławska, Urszula; Gajek, Jacek; Janiszewski, Adrian; Pasławski, Robert; Zyśko, Dorota; Nicpoń, Józef

doi:10.17219/acem/36012

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Hence, new anaesthetics are constantly sought, and the effects of the available anaesthetic drugs are being widely studied. The most common drugs used to anesthetise pigs include midazolam, azaperon, fentanyl, droperidol, ketamine and barbiturates (5,19,36). Alpha-2 adrenergic agonists, which are commonly used in companion animals, are rarely used in laboratory animals prior to cardiovascular procedures, because they reduce the blood pressure and heart rate.…”

Section: Praca Oryginalnamentioning

confidence: 99%

Effect of xylazine, medetomidine and dexmedetomidine on cardiac conduction in pigs

Cepiel¹,

Noszczyk-Nowak²,

Janiszewski³

et al. 2018

Medycyna Weterynaryjna

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SummaryThe majority of anaesthetics used in studies regarding heart arrhythmias may affect the cardiac conduction system, thus influencing the results. In veterinary medicine, xylazine, medetomidine and dexmedetomidine are commonly used for premedication in laboratory and companion animals. To date, there have been no studies assessing the effect of these substances on the cardiac conduction system. The aim of this study was to assess the effect of xylazine, medetomidine and dexmedetomidine on the parameters of the cardiac conduction system in pigs. The study was carried out on 18 Great White Polish male pigs weighing from 21 to 40 kg. The animals were divided into three equal groups. The animals from the first group received xylazine at a dose of 2 mg/ kg i.v.; those from the second group received medetomidine at 40 mcg/kg i.v.; and those from the third group received dexmedetomidine at 10 mcg/kg i.v. The electrophysiological activity of the heart was analysed using an invasive electrophysiological study (EPS). During the EPS, a decrease in the heart rate after substance administration was observed in all animals, but there were no statistically significant differences in the cardiac conduction parameters. A pro-arrhythmic effect of xylazine was observed, but no statistically significant changes in the EPS parameters were noted. Our results indicate that medetomidine and dexmedetomidine may be used as standard premedication drugs in electrophysiological studies in pigs. Their use may facilitate animal preparation procedures without affecting study results.

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Section: Praca Oryginalnamentioning

confidence: 99%

Effect of xylazine, medetomidine and dexmedetomidine on cardiac conduction in pigs

Cepiel¹,

Noszczyk-Nowak²,

Janiszewski³

et al. 2018

Medycyna Weterynaryjna

Self Cite

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Intrathoracic aerosol chemotherapy via spray‑catheter

et al. 2020

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Pressurized intrathoracic aerosol chemotherapy (PITAC) has been introduced to the clinical setting as a novel treatment option for pleural metastasis (PM). For decades the therapeutic application of aerosols was limited to intrabronchial delivery. However, present studies suggest performing PITAC on patients with PM and malignant pleural effusion. Using an established ex vivo swine model, the present study aimed to introduce a facilitated intrathoracic chemoaerosol application via spray-catheter. Using an ex-vivo model of 3 postmortem swine, the feasibility of intrathoracic aerosol chemotherapy (ITC) with doxorubicin using a spray-catheter was evaluated in a normal pressure environment. Following thoracotomy, the spray-catheter was inserted via trocar. Tissue samples were retrieved and further analyzed by fluorescence microscopy to detect doxorubicin contact. Our data demonstrated that the application of ITC was technically feasible and did not exhibit any significant obstacles. By making a minimally invasive thoracotomy incision it was possible to create an adequate pneumothorax without the need of a double-lumen tube or intubation. ITC did not require the creation of a pressurized environment. Tissue samples revealed doxorubicin contact within the pleura. In conclusion, ITC is a fast and feasible procedure that could possibly be administered via bedside application, therefore eliminating the need of an operating room and surgical staff. However, further studies are required to evaluate the safety of patients and physicians regarding this novel applicational modality. Nevertheless, the present study demonstrated that ITC may potentially be applied at bedside, an option that is particularly important for patients who do not qualify for PITAC procedures.

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Ventricular Effective Refraction Period and Ventricular Repolarization Analysis in Experimental Tachycardiomyopathy in Swine

Cited by 2 publications

References 9 publications

Effect of xylazine, medetomidine and dexmedetomidine on cardiac conduction in pigs

Effect of xylazine, medetomidine and dexmedetomidine on cardiac conduction in pigs

Intrathoracic aerosol chemotherapy via spray‑catheter

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