Ventricular enlargement in normal weight bulimia

Kiriike, Nobuo; Nishiwaki, S.; Nagata, Toshihiko; Inoue, Yumiko; Inoue, Kentaro; Kawakita, Yukio

doi:10.1111/j.1600-0447.1990.tb03064.x

Cited by 8 publications

(3 citation statements)

References 19 publications

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“…Early studies analyzed total GM or WM and cerebrospinal fluid volumes. The first structural studies have shown potential brain atrophy19, 20 or widening of the sulci and enlargement of the ventricles despite normal body weight 21–23. With advancement in technology using “voxel‐based morphology” (VBM), that is, a whole brain analysis of structural brain images that are normalized to a standard space and compared across groups, studies now can in much more detail investigate localized volume alterations that could be related to a specific brain disorder.…”

Section: Introductionmentioning

confidence: 99%

White matter integrity is reduced in bulimia nervosa

Mettler

Shott

Pryor

et al. 2013

Intl J Eating Disorders

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Objective To investigate brain white matter (WM) functionality in bulimia nervosa (BN) in relation to anxiety. Method Twenty-one control (CW, mean age 27±7 years) and 20 BN women (mean age 25±5 years) underwent brain diffusion tensor imaging (DTI) to measure fractional anisotropy (FA; an indication of WM axon integrity) and the apparent diffusion coefficient (ADC; reflecting WM cell damage). Results FA was decreased in BN in the bilateral corona radiata extending into the posterior limb of the internal capsule, the corpus callosum, the right sub-insular white matter and right fornix. In CW but not BN trait anxiety correlated negatively with fornix, corpus callosum and left corona radiata FA. ADC was increased in BN compared to CW in the bilateral corona radiata, corpus callosum, inferior fronto-occipital and uncinate fasciculus. Alterations in BN WM functionality were not due to structural brain alterations. Discussion WM integrity is disturbed in BN, especially in the corona radiate, which has been associated with taste and brain reward processing. Whether this is a premorbid condition or an effect from the illness is yet uncertain. The relationships between WM FA and trait anxiety in CW but not BN may suggest that altered WM functionality contributes to high anxious traits in BN.

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Section: Introductionmentioning

confidence: 99%

White matter integrity is reduced in bulimia nervosa

Mettler

Shott

Pryor

et al. 2013

Intl J Eating Disorders

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show abstract

“…General cerebral atrophy is also shown but to a lesser extent, in patients with BN . Furthermore, research has shown that patients with BN have enlarged lateral ventricles although normal weight which suggests that the enlarged ventricles are not only because of low weight but may be a predisposing disturbance in the development of an ED . In studies of brain lesions, it has been shown that simple changes in appetite and eating behaviour occur with hypothalamic and brain stem lesions but diagnostic EDs are associated with right frontal and temporal lobe damage .…”

Section: Resultsmentioning

confidence: 99%

The neurobiology of eating disorders—a clinical perspective

Hausswolff-Juhlin

Brooks

Larsson³

2014

Acta Psychiatr Scand

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“…Thus, brain atrophy observed in AN tends to be seen less frequently in BN, Overall, there are fewer studies and less evidence of significant brain atrophy in BN compared to AN, and this, in part, could be a reflection of normal weight status and better nutritional status in BN compared to AN. However, it is important to note that the cardinal behaviours of BN including repeated efforts to restrict food intake to counteract episodes of binge eating coupled with periods of frank starvation are likely to produce some overlap in brain morphology with AN, such as ventricular enlargement as noted by Kiriike et al (1990).…”

Section: Structural Studiesmentioning

confidence: 98%

Review

Stamatakis

Hetherington²

2003

Nutritional Neuroscience

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Neuroanatomical and functional studies in the eating disorders (ED) are reviewed. Typically, anorexia nervosa (AN) is associated with cerebral spinal fluid spaces enlargement which generally recover as a function of re-feeding. However, specific cortical areas fail to correct in weight restored anorectic patients suggesting trait-related abnormalities. Functional changes in AN associated with starvation reverse with weight recovery, however, reduced 5-HT2A receptor binding may be fundamental to the pathophysiology of AN since this remains after long term weight restoration. Structural studies of bulimia nervosa (BN) provide evidence of brain atrophy, in the absence of significant weight loss but potentially related to chronic dietary restriction. Functional investigations reveal reduced thalamic and hypothalamic serotonin transporter availability in BN which increases with longer illness duration. Thus, BN is associated with substantial structural and functional alterations despite normal weight. Recent advances in neuroimaging techniques and their interpretation are increasing our understanding of normal processes in the control of food intake including neuroanatomical correlates of hunger and satiety. Taken together with the structural and functional changes observed in the ED, neuroimaging provides a powerful platform to identify the underlying trait-related pathophysiological mechanisms in the aetiology and maintenance of AN and BN.

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Ventricular enlargement in normal weight bulimia

Cited by 8 publications

References 19 publications

White matter integrity is reduced in bulimia nervosa

White matter integrity is reduced in bulimia nervosa

The neurobiology of eating disorders—a clinical perspective

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