Ventricular fibrillation and defibrillation—What are the major unresolved issues?

Ideker, Raymond E.; Walcott, Gregory P.; Epstein, Andrew E.; Plumb, Vance J.; Kay, Neal

doi:10.1016/j.hrthm.2005.02.009

Cited by 12 publications

(8 citation statements)

References 17 publications

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“…Knowledge of the type of VF may help optimise therapy. 46 (iii) Defibrillation mechanism Unlike the single threshold concept for pacing, there is no single discrete threshold energy for defibrillation. Defibrillation is measured as a probability of success, with a 'threshold' being given as a percentage success.…”

Section: Reduction In Energy Requirementsmentioning

confidence: 99%

Development of Device Therapy for Ventricular Arrhythmias

Holley

2007

Heart, Lung and Circulation

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Section: Reduction In Energy Requirementsmentioning

confidence: 99%

Development of Device Therapy for Ventricular Arrhythmias

Holley

2007

Heart, Lung and Circulation

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“…Although conventional antiarrhythmic drugs have been reported to be effective in preventing arrhythmias, they themselves can cause lethal arrhythmias in some clinical conditions. It is known that electrical defibrillation is the only effective way to treat ventricular fibrillation [4]. Currently, the shock strength required to successfully defibrillate is still high.…”

Section: Introductionmentioning

confidence: 99%

Fluorinated 3,4-Dihydro-2H-1,4-Benzothiazin- 1,1-Dioxide Derivatives with Antiarrhythmic and Hypertensive Effects

Ao¹

2021

AJBSR

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A series of fluorinated 3,4-dihydro-2H-1,4-benzothiazine derivatives was synthesized starting from pentafluorobenzoic acid and 2-mercaptoethanol via aromatic nucleophilic substitution of fluorine atoms. They were characterized by spectral methods, X-ray diffraction analysis, and screened for the cardiotropic activity in vivo on mature male rats of line Wistar. The presence of a possible antiarrhythmic activity in the selected derivatives was tested, as was the effect on blood pressure in widely accepted models of arrhythmia. It was found that this series of chemical compounds has an antiarrhythmic effect and causes a monotonic increase in blood pressure within 3-5min. As the most promising agents were selected 5,7difluoro-3,4-dihydro-2H-benzo[1,4]thiazine-1,1-dioxide derivatives 3c and 5, containing a cyclopentylamine fragment at position 8.

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“…Mapping of electrical activation during VF has long been recognized as technically difficult and challenging task 16 . A variety approaches to VF mapping have been used previously, including transmural needles, epicardial mapping, and optical mapping 1,16–19 . Endocardial mapping approaches have been less common 16 …”

Section: Introductionmentioning

confidence: 99%