Ventricular outflow tract obstruction: An in-silico model to relate the obstruction to hemodynamic quantities in cardiac paediatric patients

Comunale, Giulia; Padalino, Massimo A.; Maiorana, Carmelo; Salvo, Giovanni Di; Susin, Francesca Maria

doi:10.1371/journal.pone.0258225

Cited by 2 publications

(2 citation statements)

References 35 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In cases where the patent ductus arteriosus (PDA) is closed and no collateral supply exists, the severity of RVOTO becomes a determining factor in the degree of hypoxemia observed in the patient upon presentation [15].…”

Section: Dynamic Right Ventricular Outflow Tract Obstruction (Rvoto)mentioning

confidence: 99%

Overview of the Most Prevalent Pediatric Congenital Heart Diseases: A Literature Review

Elsedawy

2023

AJPR

View full text Add to dashboard Cite

Like every other prevalent disease process, cardiovascular diseases pose a great risk for the morbidity and mortality of human beings. Pediatric cardiovascular disease (CVD) represents a broad spectrum of disorders that affect both the heart and blood vessels in the pediatric population. There have been several epidemiological studies done to highlight the prevalence and incidence of various pediatric CVDs, emphasizing the impact on global child health. Notably, congenital heart defects, acquired heart diseases, and cardiomyopathies contribute to the majority of pediatric CVDs. Understanding the prevalence and distribution of these conditions is important for resource allocation and healthcare planning. Similarly, several risk factors contribute to the development and progression of pediatric CVD. Genetic predisposition, prenatal exposures, environmental factors, and lifestyle choices all play pivotal roles. Identifying and addressing these risk factors is essential for early intervention and preventive strategies. However, advances in diagnostic modalities have revolutionized the assessment of pediatric CVD. Non-invasive imaging techniques, genetic testing, and biomarker analyses enable earlier and more accurate detection, facilitating timely intervention and personalized treatment plans. Additionally, emerging therapeutic approaches, including innovative medical interventions and surgical techniques, are transforming the landscape of pediatric CVD management. This abstract aims to serve as a concise resource for clinicians, researchers, and physicians interested in pediatric cardiovascular health. By understanding the epidemiology, recognizing key risk factors, and staying aware of the emerging trends in diagnosis and management, people can contribute to improved outcomes and enhanced quality of life for children affected by cardiovascular diseases.

show abstract

Section: Dynamic Right Ventricular Outflow Tract Obstruction (Rvoto)mentioning

confidence: 99%

Overview of the Most Prevalent Pediatric Congenital Heart Diseases: A Literature Review

Elsedawy

2023

AJPR

View full text Add to dashboard Cite

show abstract

“…The pulse duplicator harnessed the advantages of the lumped-parameter approach and was successfully used to model the pathophysiological conditions of flows and pressures in cardiovascular circulation [24][25][26]. It was composed of the left ventricle, the aortic valve, the ascending aorta up to the first portion of the descending aorta, the systemic resistances, the left atrium, and the mitral valve (see Figure 2).…”

Section: Experimental Set-upmentioning

confidence: 99%

Distensibility of Deformable Aortic Replicas Assessed by an Integrated In-Vitro and In-Silico Approach

et al. 2022

Self Cite

View full text Add to dashboard Cite

The correct estimation of the distensibility of deformable aorta replicas is a challenging issue, in particular when its local characterization is necessary. We propose a combined in-vitro and in-silico approach to face this problem. First, we tested an aortic silicone arch in a pulse-duplicator analyzing its dynamics under physiological working conditions. The aortic flow rate and pressure were measured by a flow meter at the inlet and two probes placed along the arch, respectively. Video imaging analysis allowed us to estimate the outer diameter of the aorta in some sections in time. Second, we replicated the in-vitro experiment through a Fluid-Structure Interaction simulation. Observed and computed values of pressures and variations in aorta diameters, during the cardiac cycle, were compared. Results were considered satisfactory enough to suggest that the estimation of local distensibility from in-silico tests is reliable, thus overcoming intrinsic experimental limitations. The aortic distensibility (AD) is found to vary significantly along the phantom by ranging from 3.0 × 10−3 mmHg−1 in the ascending and descending tracts to 4.2 × 10−3 mmHg−1 in the middle of the aortic arch. Interestingly, the above values underestimate the AD obtained in preliminary tests carried out on straight cylindrical samples made with the same material of the present phantom. Hence, the current results suggest that AD should be directly evaluated on the replica rather than on the samples of the adopted material. Moreover, tests should be suitably designed to estimate the local rather than only the global distensibility.

show abstract

Ventricular outflow tract obstruction: An in-silico model to relate the obstruction to hemodynamic quantities in cardiac paediatric patients

Cited by 2 publications

References 35 publications

Overview of the Most Prevalent Pediatric Congenital Heart Diseases: A Literature Review

Overview of the Most Prevalent Pediatric Congenital Heart Diseases: A Literature Review

Distensibility of Deformable Aortic Replicas Assessed by an Integrated In-Vitro and In-Silico Approach

Contact Info

Product

Resources

About