Ventricular remodeling and diastolic myocardial dysfunction in rats submitted to protein-calorie malnutrition

Fioretto, José Roberto; Querioz, Susana S.; Padovani, Carlos Roberto; Matsubara, Luiz Shiguero; Okoshi, Katashi; Matsubara, Beatriz Bojikian

doi:10.1152/ajpheart.00431.2001

Cited by 32 publications

(34 citation statements)

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“…This comes in agreement with Ocal et al (2001) who reported that the diastolic function indices were not significantly affected in malnourished patients. Fioretto et al (2002) also reported that there is a geometric alteration of the left ventricle with preserved ventricular compliance and distensibility despite increased passive myocardial stiffness.…”

Section: Discussionmentioning

confidence: 95%

Structural and functional affection of the heart in protein energy malnutrition patients on admission and after nutritional recovery

et al. 2005

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Background and objectives: The pathogenesis of different malnutrition diseases was suggested to affect the heart. This study was designed to detect cardiac affection in protein energy malnutrition (PEM) patients, whether clinically or by electrocardiogram (ECG) and echocardiogram, and to assess the value of the cardiac marker troponin I in patients at risk of myocardial injury with special emphasis on the effect of nutritional rehabilitation. Patients and methods: The present study was carried out on 30 PEM infants (16 nonedematous -14 edematous) and 10 apparently healthy age and sex-matched infants acting as the control group. All studied infants were subjected to full history taking laying stress on dietetic history, thorough clinical and anthropometric measurements. Echocardiography and ECG were also performed. Laboratory investigations were performed including complete blood count, CRP, total proteins, albumin, liver and kidney functions as well as estimation of troponin-I in blood by immulite. Following initial evaluation, all malnourished infants were subjected to nutritional rehabilitation program for approximately 8 weeks, after which the patients were reevaluated using the same preinterventional parameters. Results: The results of the present study demonstrated that electrical properties of myocardium assessed by ECG showed significant decrease of R wave and QTc interval in patients compared to controls with significant improvement after nutritional rehabilitation. Echocardigraphic changes showed that cardiac mass index was significantly lower in both groups of malnourished cases compared to the controls with significant increase after nutritional rehabilitation. The study showed that the parameters of left ventricular (LV) systolic function which are the ejection fraction, fractional shortening and velocity of circumferential fiber shortening were not significantly reduced in patients compared to the controls. The diastolic function also showed no significant difference in the E wave/A wave (e/a) ratio between patients and controls. However, the systolic time interval showed significantly higher LV pre-ejection index in patients in comparison to controls. Edematous and nonedematous cases did not show any significant differences in ECG and echocardigraphic data before or after nutritional rehabilitation. The hearts of two severely affected patients uniquely demonstrated marked decrease of LV end diastolic diameter (LEVDd) together with the detection of troponin-I in their sera. Conclusion: We can conclude that malnutrition, regardless of its type, has a definite effect on cardiac volume, muscle mass, as well as the electrical properties of the myocardium. The systolic functions of the heart are affected more than the diastolic functions and this affection becomes manifest only in severe cases and may constitute a bad prognostic parameter thus necessitating more intense management and strict follow-up of such cases.

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Section: Discussionmentioning

confidence: 95%

Structural and functional affection of the heart in protein energy malnutrition patients on admission and after nutritional recovery

et al. 2005

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“…In normotensive animals, morphological, ultrastructural, and functional myocardial changes were slight. [77][78][79][80][81][82] However, in the hypertrophied heart of hypertensive rats, structural changes were more severe and were combined with ventricular and myocardial systolic dysfunction. [83][84][85][86] Therefore, severe food restriction induces mild morphological and functional changes in normal hearts, which are exacerbated in hemodynamic overloaded hearts.…”

Section: Clinical Consequences Of Cachexiamentioning

confidence: 99%

Cardiac cachexia and muscle wasting: definition, physiopathology, and clinical consequences

Okoshi¹,

Romeiro²,

Martínez³

et al. 2014

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Cachexia and muscle wasting are frequently observed in heart failure patients. Cachexia is a predictor of reduced survival, independent of important parameters such as age, heart failure functional class, and functional capacity. Muscle and fat wasting can also predict adverse outcome during cardiac failure. Only more recently were these conditions defined in International Consensus. Considering that heart failure is an inflammatory disease, cardiac cachexia has been diagnosed by finding a body weight loss .5%, in the absence of other diseases and independent of other criteria. Muscle wasting has been defined as lean appendicular mass corrected for height squared of 2 standard deviations or more below the mean for healthy individuals between 20 years and 30 years old from the same ethnic group. The etiology of heart failure-associated cachexia and muscle wasting is multifactorial, and the underlying physiopathological mechanisms are not completely understood. The most important factors are reduced food intake, gastrointestinal alterations, immunological activation, neurohormonal abnormalities, and an imbalance between anabolic and catabolic processes. Cachexia and muscle wasting have clinical consequences in several organs and systems including the gastrointestinal and erythropoietic systems, and the heart, previously affected by the primary disease. We hope that a better understanding of the mechanisms involved in their physiopathology will allow the development of pharmacological and nonpharmacological therapies to effectively prevent and treat heart failure-induced cachexia and muscle wasting before significant body weight and muscle wasting occurs.

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“…Estudos têm demonstrado o efeito permanente do déficit de peso corpóreo promovido pela agressão nutricional quando aplicada durante a gestação e aleitamento 2,24,25 ou somente no período de aleitamento 26,27 . Essas adaptações do organismo à desnutrição podem ser metabólicas e endócrinas.…”

Section: I S C U S S ã Ounclassified

Condicionamento físico aeróbio moderado promove redução no rápido ganho de peso de ratos adultos desnutridos nos períodos de gestação e lactação

et al. 2010

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ObjetivoForam avaliados os efeitos do condicionamento físico aeróbio moderado sobre o peso corporal e o ganho de peso de animais submetidos à desnutrição na gestação e lactação e alimentados com dieta normoprotéica após o desmame. MétodosRatos machos Wistar foram gerados e amamentados por nutrizes alimentadas com dieta normoprotéica (caseína 17%) e dieta hipoprotéica (caseína 8%), formando os grupos Nutridos (n=18) e Desnutridos (n=17) inicialmente e, após o desmame, foram alimentados com dieta normoprotéica padrão do biotério (Labina ® , Purina). Aos 60 1 Artigo elaborado a partir da dissertação de T.N. ARAÚJO, intitulada "Efeitos do treinamento físico aeróbio moderado sobre o crescimento corporal e desenvolvimento cardíaco de ratos adultos submetidos à desnutrição protéica na gestação e

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Ventricular remodeling and diastolic myocardial dysfunction in rats submitted to protein-calorie malnutrition

Abstract: . Ventricular remodeling and diastolic myocardial dysfunction in rats submitted to protein-calorie malnutrition.

Cited by 32 publications

References 43 publications

Structural and functional affection of the heart in protein energy malnutrition patients on admission and after nutritional recovery

Structural and functional affection of the heart in protein energy malnutrition patients on admission and after nutritional recovery

Cardiac cachexia and muscle wasting: definition, physiopathology, and clinical consequences

Condicionamento físico aeróbio moderado promove redução no rápido ganho de peso de ratos adultos desnutridos nos períodos de gestação e lactação

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