Ventricular septal hamartoma mimicking hypertrophic cardiomyopathy in a 41-year-old woman presenting with paroxysmal supraventricular tachycardia

Hamartomas of mature cardiac myocytes: report of 7 new cases and review of literature

“…Overall, published data exist for 15 patients with hamartomas of mature cardiac myocytes, including our 7 new cases and 8 previously reported ones (Table 3) [1][2][3][4]6]. Ages ranged from 6 months to 74 years (mean, 28 years; median, 24 years).…”

“…Although it has been described as well demarcated, in our experience, poorly-defined lesions were the rule [1]. Lesions are characterized by disorganized myocytes that also underwent hypertrophy and by variable interstitial fibrosis and adiposity [1][2][3][4][5][6]. Myocyte disorganization or disarray includes 3 patterns: (1) haphazard, (2) herringbone, and (3) whorl or pinwheel.…”

“…An eighth case had been previously reported [3]. The project was approved by the Mayo institutional review board.…”

“…Hamartomas of mature cardiac myocytes are rare and, to our knowledge, have been reported in only 8 patients [1][2][3][4][5][6]. As such, their clinicopathologic spectrum is not yet well defined in the literature.…”

Rare Case of Hamartoma Mimicking Fibroma and Correlations with Literature

“…Since minor surgical or biopsy specimens represent the only tissue available for evaluation removed from the ventricular septum, the distinction of HA from hypertrophic cardiomyopathy (HCM) may be impossible microscopically [1,7,15]. Therefore, the two can be differentiated only in light of clinical findings and imaging studies [1].…”