Ventricular structure, function, and focal fibrosis in anabolic steroid users: a CMR study

Angell, Peter J.; Ismail, Tevfik F; Jabbour, Andrew; Smith, Gillian; Dahl, Annette L; Wage, Ricardo; Whyte, Greg; Green, Daniel; Prasad, Sanjay; George, Keith

doi:10.1007/s00421-014-2820-2

Cited by 29 publications

(24 citation statements)

References 29 publications

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“…Cardiac fibrosis was more common and outstanding when compared to hypertrophy in cardiac muscles. These lesions and others such as disorganized muscle fibers, misshapen nuclei and increasing apoptosis have also been described in previous studies (Belhani et al 2009, Papamitsou et al 2011, Angell et al 2012, Angell et al 2014.…”

Section: Discussionsupporting

confidence: 78%

Yetişkin ve Kastre Edilmiş Erkek Ratlarda Yüksek Doz Testosteron Propiyonatın İndüklediği Kardiyak Fibrozis Üzerine Lonidamin Yüklü Lipit-Polimer Hibrit Nanopartiküllerin Etkisi

Alçığır

Sengel-Türk

Ekim

et al. 2018

Kocatepe Veterinary Journal

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In recent years, the usage of exogenous testosterone has tripled in humans. Although, mechanism has not yet been fully elucidated, there is a correlation between the increased risk of heart failure and testosterone usage. The aim of this study was to demonstrate cardiac fibrosis, which a main finding of hearth failure, in testosterone propionate-applied male rats and to show its regression by Lonidamine as an anti-hyperplastic agent. A total of 72 adult Wistar albino and neutralized male rats were divided into 4 groups (n=18 in each groups). Animals in all groups were received to testosterone propionate until 2nd, 4th, and 12th weeks (n=6 in each groups). Subsequently, group I and II also received the pure solution of Lonidamine hydrochloride and its lipid-polymer hybrid nanoparticulate formulation via intraprostatic injection. Group III, blank lipid-polymer hybrid nanoparticle formulation were solely administrated via same way. The control group or group IV were received only testosterone. At the end of the experiment period, hearts were collected and fibrocytic changes were confirmed by histochemical and immunohistochemical methods. Histopathologically, fibrosis were lower in group I and II when comprared to that of group III and IV. Imunohistochemically, bFGF, cyclin D1 and p16 protein expressions were evaluated. bFGF and cyclinD1 epxressions correspondingly to increasing fibrosis were found higher in last two groups during the experiment. But, p16 expressions were lower in Lonidamine treated-group I and II. In conclusion, results of this study supported that testosterone propionate may promote cardiac fibrosis. Lonidamine hydrochloride may be used in its prevention of fibrosis.

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Section: Discussionsupporting

confidence: 78%

Yetişkin ve Kastre Edilmiş Erkek Ratlarda Yüksek Doz Testosteron Propiyonatın İndüklediği Kardiyak Fibrozis Üzerine Lonidamin Yüklü Lipit-Polimer Hibrit Nanopartiküllerin Etkisi

Alçığır

Sengel-Türk

Ekim

et al. 2018

Kocatepe Veterinary Journal

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“…Furthermore, some recent innovative diagnostic techniques, such as pulsed-wave tissue Doppler imaging and ultrasonic-integrated backscatter cyclic variation analysis [19] and cardiac magnetic resonance (CMR) [20], documented regional systolic and diastolic dysfunction in AAS users with respect to AAS non-users or control cases. Angell and colleagues [21] could detect pathological alterations of ventricular structure and dysfunction in the hearts of AAS users in CMR analyses. However, focal cardiac fibrosis, which is almost found histopathologically in AAS users, could not be detected by the use of CMR.…”

Section: Discussionmentioning

confidence: 98%

Ventricular androgenic-anabolic steroid-related remodeling: an immunohistochemical study

Cecchi¹,

Muciaccia

Ciallella

et al. 2017

Int J Legal Med

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“…This is in stark contrast to the work of Abergel et al, 4 who found 8.7% of elite cyclists presented a MWT exceeding 13 mm. It is difficult to speculate as to the reason for this disparity, however, the authors themselves report the potential confounding impact of performance‐enhancing drugs used by cyclists during the 1990s and early 2000s, many of which are known to elicit concentric LVH 35 . Better endocardial border differentiation from a combination of improvement in echocardiography technology and experience in defining true endocardium from LV trabeculation may potentially have also contributed to previously erroneous measurements.…”

Section: Discussionmentioning

confidence: 99%

Left ventricular remodeling in elite and sub‐elite road cyclists

Brown

Millar

Somauroo

et al. 2020

Scandinavian Med Sci Sports

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Marked adaptation of left ventricular (LV) structure in endurance athletes is well established. However, previous investigations of functional and mechanical adaptation have been contradictory. A lack of clarity in subjects’ athletic performance level may have contributed to these disparate findings. This study aimed to describe structural, functional, and mechanical characteristics of the cyclists’ LV, based on clearly defined performance levels. Male elite cyclists (EC) (n = 69), sub‐elite cyclists (SEC) (n = 30), and non‐athletes (NA) (n = 46) were comparatively studied using conventional and speckle tracking 2D echocardiography. Dilated eccentric hypertrophy was common in EC (34.7%), but not SEC (3.3%). Chamber concentricity was higher in EC compared to SEC (7.11 ± 1.08 vs 5.85 ± 0.98 g/(mL)2/3, P < .001). Ejection fraction (EF) was lower in EC compared to NA (57 ± 5% vs 59 ± 4%, P < .05), and reduced EF was observed in a greater proportion of EC (11.6%) compared to SEC (6.7%). Global circumferential strain (GCε) was greater in EC (−18.4 ± 2.4%) and SEC (−19.8 ± 2.7%) compared to NA (−17.2 ± 2.6%) (P < .05 and P < .001). Early diastolic filling was lower in EC compared with SEC (0.72 ± 0.14 vs 0.88 ± 0.12 cm/s, P < .001), as were septal E’ (12 ± 2 vs 15 ± 2 cm/s, P < .001) and lateral E’ (18 ± 4 vs 20 ± 4 cm/s, P < .05). The magnitude of LV structural adaptation was far greater in EC compared with SEC. Increased GCε may represent a compensatory mechanism to maintain stroke volume in the presence of increased chamber volume. Decreased E and E’ velocities may be indicative of a considerable functional reserve in EC.

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Ventricular structure, function, and focal fibrosis in anabolic steroid users: a CMR study

Abstract: AS use was associated with significant LV hypertrophy, albeit in-line with greater fat-free mass, reduced LV strain, diastolic function, and reduced RV ejection fraction in male bodybuilders. There was, however, no evidence of focal fibrosis in any AS user.

Cited by 29 publications

References 29 publications

Yetişkin ve Kastre Edilmiş Erkek Ratlarda Yüksek Doz Testosteron Propiyonatın İndüklediği Kardiyak Fibrozis Üzerine Lonidamin Yüklü Lipit-Polimer Hibrit Nanopartiküllerin Etkisi

Yetişkin ve Kastre Edilmiş Erkek Ratlarda Yüksek Doz Testosteron Propiyonatın İndüklediği Kardiyak Fibrozis Üzerine Lonidamin Yüklü Lipit-Polimer Hibrit Nanopartiküllerin Etkisi

Ventricular androgenic-anabolic steroid-related remodeling: an immunohistochemical study

Left ventricular remodeling in elite and sub‐elite road cyclists

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