“…Although it may have contributed in some of the patients, nonischemic substrates need to be considered in the remaining 28% without progressive CAD and even still in those with progressive CAD. VF storm resulting from Brugada syndrome, arrhythmogenic right ventricular cardiomyopathy, long QT syndrome, or idiopathic VF in structurally normal hearts originating from the His-Purkinje system, papillary muscles, or moderator band need to be expeditiously diagnosed via thorough analysis of electrocardiograms, imaging, and clinical history to guide specific unique strategies such as usage of correct medications, atrial pacing, or early ablation [1,8]. In fact, several of these diagnoses were observed in the non-CAD group presenting with ES in the current study and may explain the seemingly low prevalence of progressive CAD in the VF group.…”