Ventriculitis: experiencia en un servicio de neonatología

Rincón, N. Nieto del; Romero, Concepción de Alba; Nadal, Paula; Beato, Fernando Mateos; Ibañez, Mónica; Molina, María; Castillo, Espinoza

doi:10.1016/s1695-4033(00)77331-0

Cited by 3 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…En nuestra experiencia el paciente fue diagnosticado con ventriculitis. Esta afección puede ser consecuencia de una infección del SNC o puede ser adquirida en un 6-38% después de un procedimiento neurológico invasivo (14) .…”

Section: Discussionunclassified

Neonato con ventriculitis causada por Empedobacter brevis: reporte de un caso en Perú

Rojas-Contreras

Cruz-Ku

Eyzaguirre-Sandoval

et al. 2018

Rev Peru Med Exp Salud Publica

View full text Add to dashboard Cite

Infections caused by rare micro-organisms are the subject of research, as researchers are encouraged to find the necessary health measures to prevent and treat the disease, as well as the search for new insights into human-microbial interactions. This report describes the case of a newborn boy diagnosed with hydrocephalus and myelomeningocele who developed ventriculitis and sepsis from resistant Empedobacter brevis. This case highlights the unexpected identification of this bacterium in the cerebrospinal fluid and its multi-resistant pattern, which was crucial for proper therapeutic management. This bacterium shows a mixture of different etiologies in the analysis of cerebrospinal fluid.

show abstract

Section: Discussionunclassified

Neonato con ventriculitis causada por Empedobacter brevis: reporte de un caso en Perú

Rojas-Contreras

Cruz-Ku

Eyzaguirre-Sandoval

et al. 2018

Rev Peru Med Exp Salud Publica

View full text Add to dashboard Cite

show abstract

“…Most of these studies are case reports [19][20][21][22][23][24][25][26][27][28][29][30][31] or small case series [32][33][34][35] , with very few small comparative studies (cohorts). 36,10 Another 26 studies on neonates also used intraventricular antibiotics to treat neuroinfections in neurosurgery, but they were not included in our analysis because the outcomes of interest were not specified in sufficient detail.…”

Section: A) Intraventricular Antibiotics In Neurosurgerymentioning

confidence: 99%

Systematic review and meta-analysis of intraventricular antibiotics for neonatal meningitis and ventriculitis

Valdivia,

Pérez,

Vega

et al. 2023

Childs Nerv Syst

View full text Add to dashboard Cite

Background: Many pediatric and neurosurgical studies have been published regarding intraventricular antibiotics in neonatal meningitis and ventriculitis. We aimed to determine the safety and effectiveness of intraventricular antibiotics in neonates with meningitis and/or ventriculitis and analyze the quality of available evidence. Methods:We systematically reviewed scientific literature from the PubMed, EMBASE, LILACS, and SCOPUS databases. Randomized experimental and observational studies were included. The Cochrane methodology was used for systematic reviews. Results:Twenty six observational studies and one randomized clinical trial involving 272 patients were included. The risk of bias in both pediatric and neurosurgical studies was high, and the quality of evidence was low (evidence level C). In the pediatric studies, no significant differences in mortality were found between intraventricular antibiotics and only systemic antibiotic [25.4% vs 16.1%, OR=0.96 (0.42-2.24), P=0.93]. However, when analyzing the minimum administered doses, we found a lower mortality when a minimum duration of 3 days for intraventricular antibiotics was used compared to only systemic antibiotic [4.3% vs 17%, OR=0.22 (0.07-0.72), P=0.01]. In the neurosurgical studies, the use of intraventricular antibiotics in ventriculitis generally results in a mortality of 5% and a morbidity of 25%, which is lower than that in cases where intraventricular antibiotics were not used, with an average mortality of 37.3% and a morbidity of 50%. Conclusion:Considering the low quality of evidence in pediatric and neurosurgical studies, we can conclude with a low level of certainty that intraventricular antibiotics may not significantly impact mortality in neonatal meningitis and ventriculitis. However, reduced mortality was observed in cases treated with a minimum duration of 3 days of intraventricular antibiotic, particularly the multidrugresistant or treatment-refractory infections. Higher-quality studies are needed to improve the quality of evidence and certainty regarding the use of intraventricular antibiotics for treating neonatal meningitis and ventriculitis.

show abstract

Systematic review and meta-analysis of intraventricular antibiotics for neonatal meningitis and ventriculitis

Valdivia,

Pérez,

Vega

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Many pediatric and neurosurgical studies have been published regarding intraventricular antibiotics in neonatal meningitis and ventriculitis. We aimed to determine the safety and effectiveness of intraventricular antibiotics in neonates with meningitis and/or ventriculitis and analyze the quality of available evidence. Methods: We systematically reviewed scientific literature from the PubMed, EMBASE, LILACS, and SCOPUS databases. Randomized experimental and observational studies were included. The Cochrane methodology was used for systematic reviews. Results: Twenty six observational studies and one randomized clinical trial involving 272 patients were included. The risk of bias in both pediatric and neurosurgical studies was high, and the quality of evidence was low (evidence level C). In the pediatric studies, no significant differences in mortality were found between intraventricular antibiotics and only systemic antibiotic [25.4% vs 16.1%, OR=0.96 (0.42 to 2.24), P=0.93]. However, when analyzing the minimum administered doses, we found a lower mortality when a minimum duration of 3 days for intraventricular antibiotics was used compared to only systemic antibiotic [4.3% vs 17%, OR=0.22 (0.07 to 0.72), P=0.01]. In the neurosurgical studies, the use of intraventricular antibiotics in ventriculitis generally results in a mortality of 5% and a morbidity of 25%, which is lower than that in cases where intraventricular antibiotics were not used, with an average mortality of 37.3% and a morbidity of 50%. Conclusion: Considering the low quality of evidence in pediatric and neurosurgical studies, we can conclude with a low level of certainty that intraventricular antibiotics may not significantly impact mortality in neonatal meningitis and ventriculitis. However, reduced mortality was observed in cases treated with a minimum duration of 3 days of intraventricular antibiotic, particularly the multidrug-resistant or treatment refractory infections. Higher-quality studies are needed to improve the quality of evidence and certainty regarding the use of intraventricular antibiotics for treating neonatal meningitis and ventriculitis.

show abstract

Ventriculitis: experiencia en un servicio de neonatología

Cited by 3 publications

References 24 publications

Neonato con ventriculitis causada por Empedobacter brevis: reporte de un caso en Perú

Neonato con ventriculitis causada por Empedobacter brevis: reporte de un caso en Perú

Systematic review and meta-analysis of intraventricular antibiotics for neonatal meningitis and ventriculitis

Systematic review and meta-analysis of intraventricular antibiotics for neonatal meningitis and ventriculitis

Contact Info

Product

Resources

About