Ver�nderungen der Stammlinie von Walker-Carcinomzellen durch Umweltfaktoren

Eicke, Jutta; Meiners, Maria Luise; Wrba, H.

doi:10.1007/bf00525047

Cited by 5 publications

(1 citation statement)

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“…Another significant matter resulting from the present study is that the H10Z ascitic tumor is more uniform in genetical structure than other experi mental ascitic tumors [2,19] and the metastatic effusions of human tumors [3,12,25,26]. This may be explained by the fact that in the H10Z ascitic tumor, the selection process of a new prevailing cell type is more advanced owing to the great number of peritoneal passages.…”

Section: Discussionmentioning

confidence: 61%

Studies on Tumor Variability III. H<sub>10</sub>Z Tumor Ascitic Transformation

Fadei¹

1972

Oncology

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H₁₀Z Syrian hamster tumor ascitic transformation by zig-zag intraperitoneal and tissue culture transplantation is described. This transformation takes place in 2 stages. In the first stage the amount of ascitic fluid is small and no cytogenetical modifications are found. This may be assumed to be an adapting period for a certain tumor cell type to grow in liquid medium, by genetical induction of some repressed genes, modifying its phenotypical characters. The second stage, characterized by the increase of ascitic fluid and the prevalence of ascitic tumor cells, might be explained by the selection of this genetically induced cell type from the polymorphous tumor cell population. These results support our hypothesis concerning the role of induction-selection mechanism in tumor variability.

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Section: Discussionmentioning

confidence: 61%