Ver�nderungen des Gehaltes der freien Fetts�uren und der Ketonk�rper im Blut alloxandiabetischer Ratten nach i.v. Fettbelastung und Heparinapplikation

Abstract

Changes in the serum levels of free .fatty acids and ketone bodies in aIloxan-diabetie rats after intravenous loading with fat and application of heparin.Summary. Fat, with and without simultaneous heparin has been given intravenously to normal and to chronic alloxan-diabetic rats. The concentration of free fatty acids and ketone bodies in the blood was determined a~ several intervals after the injection. Although after the i.v. administration of fat the profile of the FFA-elevation in serum was parallel in both groups, the FFA-leve]s in diabetic rats were markedly lower. Addition of heparin to the fat caused a distinct rise of FFA in serum of both groups without any differences between them. Fat loading alone, leads to a moderate elevation of the blood ketone bodies in normal and diabetic rats. Combination of fat administration with heparin increases the ketone body content in the blood of the diabetic as well as of the normal rats. This increase, however, is significantly higher in alloxan diabetic animals at the end of the few hours after the fat loading.

The Influence of Caffeine on Carbohydrate and Lipid Metabolism in Alloxan-diabetic Mice

“…This may be due to the lipolytic properties of caffeine and the increased supply of fatty acids to the liver. This assumption is in accordance with the find ings of Baumung et al [2], who observed a further increase of ketone bodies in the serum of alloxan diabetic mice when the concentration of FFA was further raised by means of fat ingestion and administration of heparin.…”

Das Verhalten von Serumlipiden alloxandiabetischer und normaler Ratten nach verschiedenartiger Applikation einer Fettemulsion

“…Injektion von «Intralipid» bei chronisch alloxandiabetischen Ratten einen niedrigeren Gehalt an freien Fettsäuren im Serum (SeFFA) gefunden als bei stoffwechsel gesunden Kontrollieren (1).…”