Verapamil, diltiazem and nifedipine inhibit vascular responses to noradrenaline, acetylcholine and 5-hydroxytryptamine in human saphenous vein

Wali, F. A.; Süer, A. H.; Greenidge, E.

doi:10.1016/0031-6989(86)90028-7

Cited by 2 publications

(2 citation statements)

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“…19 –21 However, the reported potency of calcium channel blocker-induced vasodilation in human saphenous veins is in the following decreasing order: verapamil, diltiazem, and nifedipine. 22 This difference in the potency of calcium channel blocker-induced vasodilation may be due to differences in the vessels (rat aorta vs. human saphenous vein) and contractile agonists examined (phenylephrine vs. 5-hydroxytryptamine and acetylcholine). 22…”

Section: Discussionmentioning

confidence: 99%

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Lipid emulsion alleviates the vasodilation and mean blood pressure decrease induced by a toxic dose of verapamil in isolated rat aortae and an in vivo rat model

Lee

et al. 2017

Hum Exp Toxicol

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This study aimed to examine the effects of lipid emulsion on the vasodilation and cardiovascular depression induced by toxic doses of calcium channel blockers. The effects of lipid emulsion on the vasodilation induced by bepridil, verapamil, nifedipine, and diltiazem were investigated in isolated endothelium-denuded rat aortae. The effect of lipid emulsion on the comparable hemodynamic depression induced by the continuous infusion of a toxic dose of either verapamil or diltiazem was examined in an in vivo rat model. The results showed the following decreasing order for the magnitude of lipid emulsion-mediated inhibition of vasodilation: bepridil, verapamil, nifedipine, and diltiazem. Lipid emulsion (0.5-2%) reversed the vasodilation induced by a toxic dose of verapamil, whereas only a higher concentration (2%) reversed the vasodilation induced by a toxic dose of diltiazem. Pretreatment with lipid emulsion alleviated the systolic and mean blood pressure decreases induced by a toxic dose of verapamil, whereas it had no effect on the decrease induced by diltiazem. Taken together, these results suggest that lipid emulsion alleviates the severe vasodilation and systolic blood pressure decrease induced by a toxic dose of verapamil, and this alleviation appears to be associated with the relatively high lipid solubility of verapamil.

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Section: Discussionmentioning

confidence: 99%

“…22 This difference in the potency of calcium channel blocker-induced vasodilation may be due to differences in the vessels (rat aorta vs. human saphenous vein) and contractile agonists examined (phenylephrine vs. 5-hydroxytryptamine and acetylcholine). 22…”

Section: Discussionmentioning

confidence: 99%