Veratrum nigrum inhibits the estrogenic activity of salvia miltiorrhiza bunge in vivo and in vitro

Xu, Ying; Chen, Ting; Li, Xin; kun, Qu Ya; An, Jin Na; Hong, Zheng; Zhao, Yuan; Zhang, Zi Jia; Lin, Na

doi:10.1016/j.phymed.2018.03.038

Cited by 9 publications

(2 citation statements)

References 16 publications

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“…The results suggest that QYFE treatment in a long time is maybe safer in the reproductive target tissues than EV treatment. Moreover, ERα is required for cervical and vaginal cancers development, ERα -selective agonists could increase the risk of carcinogenesis for a long-term use [19]. There are reports that ERα and ERβ produce opposite effects on human breast cancer cell proliferation and tumor formation [20].…”

Section: Discussionmentioning

confidence: 99%

Long-time qingyan formula extract treatment exerts estrogenic activities on reproductive tissues without side effects in ovariectomized rats and via active ER to ERE-independent gene regulation

Zheng

Zhao

et al. 2019

Aging

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The reproductive tissues are negatively influenced by estrogens in hormone therapy. Qingyan formula ethanol extract (QYFE)’s estrogenic effects and safety on reproductive tissues after long-term administration and its mechanism via estrogen receptor (ER) pathway haven’t been studied. Here, we characterized its estrogenic effects using ovariectomized rats together with in vitro studies for further molecular characterization. Ovariectomized rats were treated with QYFE at doses of 0.7, 1.4, and 2.8g/kg for 12 weeks. The results showed QYFE has a potent estrogenic activity, as indicated by restoring the disappeared estrous cycle, antagonizing the atrophy of uterus, vagina and mammary gland, and the estrogen decline in circulation caused by ovariectomy. In addition, QYFE upregulated ERα and ERβ expressions and had a less stimulatory effect on PCNA and ki-67 antigen in reproductive tissues compared with estradiol valerate. QYFE components can bind to ERα and ERβ, significantly increased ERα/β-ERE luciferase reporter gene expression, upregulated the expressions of ERs, PR and pS2 in MCF-7 cells at protein and gene level. All these activities were significantly inhibited by the ER antagonist ICI182,780. QYFE’s estrogenic activity maybe mediated by stimulating biosynthesis of estrogen and increasing the quantity of ERs in target tissue and via active ER to ERE-independent gene regulation.

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Section: Discussionmentioning

confidence: 99%

Long-time qingyan formula extract treatment exerts estrogenic activities on reproductive tissues without side effects in ovariectomized rats and via active ER to ERE-independent gene regulation

Zheng

Zhao

et al. 2019

Aging

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“…The ginseng saponin Rb3 [42] can enhance myocardial contractile function and can be used to treat myocardial contractile dysfunction. However, it can significantly decrease the activity of superoxide dismutase (SOD) [43], glutathione peroxidase (GSH-px), and total antioxidant capacity (T-AOC) in mice and elevate the concentration of malondialdehyde (MDA) to induce the apoptosis of spermatogenic cells.…”

Section: Cardiotonicmentioning

confidence: 99%

Research Progress of Male Reproductive Toxicity of Chinese Materia Medicas

Cheng

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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In recent years, as the infertility rate in China has been increasing year by year and semen quality decreasing, male reproductive toxicity of drugs attracts more and more attention. There are many factors that cause male reproductive toxicity, among which Chinese materia medica is an important aspect. This article will introduce the male reproductive toxicity of Chinese materia medicas grouped by different effectivenesses such as immunosuppressant, evacuant, diuretic, cardiotonic, anti-infective drug and analgesic.

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