Verbal dichotic listening performance and its relationship with EEG features in benign childhood epilepsy with centrotemporal spikes

Bulgheroni, Sara; Franceschetti, Silvana; Vago, Chiara; Usilla, Arianna; Pantaleoni, Chiara; D’Arrigo, Stefano; Riva, Daria

doi:10.1016/j.eplepsyres.2007.12.016

Cited by 39 publications

(34 citation statements)

References 38 publications

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“…With respect to the EEG, the number of RS had no significant correlation with performance in the DWPT, in agreement with various other authors who evaluated memory and language aspects, such as phonological consciousness 10,19,27 . RS in the left hemisphere could eventually cause interference in the hemispheric specialization of language processing and phonemic fluency 12,19 , but in the present study, the side of the RS was not associated with differences in performance in the DWPT, and also had no relationship with performance in other neuropsychological evaluations 1,10,11 .…”

Section: Dwpt and Aspects Of Epilepsy And Rssupporting

confidence: 76%

“…The inferior performance observed for the children in the DWPT in this study, could be related to the processing difficulties indicated by Northcott et al 10 and Bulgheroni et al, 27 .…”

Section: Dwpt and Bcectsmentioning

confidence: 48%

“…Such a finding was not confirmed by Lundberg et al 26 . According to Bulgheroni et al 27 there was a tendency for bilateral representation of the phonological processing of auditory and verbal stimuli.…”

Section: Dwpt and Bcectsmentioning

confidence: 99%

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Benign childhood epilepsy with centrotemporal spikes: word and pseudoword discrimination

Fonseca

Oliveira

Ximenes

2009

Arq. Neuro-Psiquiatr.

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-In the active phase of benign childhood epilepsy with centro-temporal spikes (BCECTS) there may be a fall in scholastic performance. Objective: To study lexical decision in children with BCECTS. Method: 42 children with BCECTS were compared with a control group with respect to their hits and response time in a visual discrimination of words and pseudowords task (DWPT). Results: The children with BCECTS had a lower percentage of hits for words and pseudowords and showed longer response times for pseudowords. They also frequently showed inferior reading and writing performance in the school performance test. The percentage of hits for pseudowords was lower when there was bilateral, asynchronous epileptiform activity. Conclusions: The DWPT provided contributions for reading assessments in children with BCECTS. The results indicated the need for attention in detecting reading difficulties in children with BCECTS.KEY WORDS: benign childhood epilepsy with centrotemporal spikes, rolandic epilepsy, EEG, epileptiform activity, reading, cognition. Epilepsia benigna da infância com pontas centro-temporais: discriminação entre palavras e pseudopalavrasResumo -Na fase ativa da epilepsia benigna da infância com pontas centrotemporais (EBICT) pode ocorrer queda de desempenho escolar. Objetivo: Estudar a decisão lexical em crianças com EBICT. Método: 42 crianças com EBICT foram comparadas a grupo controle quanto a acertos e tempo de resposta em tarefa de discriminação visual entre palavras e pseudopalavras (DVPPS). Resultados: As crianças com EBICT tiveram percentual menor de acertos para palavras e pseudopalavras e maior tempo de resposta para pseudopalavras e tiveram, mais frequentemente, desempenho inferior em escrita e leitura em teste de desempenho escolar. Houve relação significativa entre os resultados do DVPPS e o teste de desempenho escolar. A percentagem de acerto de pseudopalavras foi menor quando havia atividade epileptiforme bilateral e assíncronia no

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Section: Dwpt and Aspects Of Epilepsy And Rssupporting

confidence: 76%

“…The inferior performance observed for the children in the DWPT in this study, could be related to the processing difficulties indicated by Northcott et al 10 and Bulgheroni et al, 27 .…”

Section: Dwpt and Bcectsmentioning

confidence: 48%

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Benign childhood epilepsy with centrotemporal spikes: word and pseudoword discrimination

Fonseca

Oliveira

Ximenes

2009

Arq. Neuro-Psiquiatr.

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“…Riva et al (2007) found that children with a left-sided spike focus scored significantly worse than controls on phonemic fluency, while children with a rightsided spike focus scored significantly worse than controls in the Vocabulary subtest of the WISC-R and in the lexical comprehension test. Bulgheroni et al (2008) found no specific influence of the side of the interictal spikes on DL performance. Correlating the topography of the focus (in terms of the hemispheric localization and the side) with neuropsychological impairments is particularly difficult in BECTS, because spike location varies as the disorder evolves (Pinton et al, 2006) and there are reports of bilateral oscillations for the lateralized time-domain spike, suggesting a synchronized activity in a network of bilateral rolandic neurons (Lin et al, 2006).…”

Section: Relationship Between Neuropsychological Data and Clinical Fementioning

confidence: 77%

“…Northcott et al (2005) found no correlation between spike burden and difficulties in memory or phonological awareness, while Weglage et al (1997) quantified spike frequency but did not correlate this with specific neuropsychological and language functions. Using a semiquantitative measure of spikes in EEGs recorded while awake, Staden et al (1998) found a trend towards higher language dysfunction rates with more frequent epileptogenic discharges, whereas Bulgheroni et al (2008) found no significant link between DL performance and interictal discharge rate, suggesting that cortical dysfunctional states depend on protracted periods of hyper-excitability leading to centrotemporal spikes, rather than on the time course (and quantity) of the spikes at the time of the DL test. It might be argued that the lack of any correlation between spike rate and neuropsychological data is due to the interval between the EEG recording on which the interictal spike rate was calculated and the neuropsychological assessment being too long to enable a detailed correlation analysis between the electrophysiological and cognitive measures, but Wolff et al (2005) conducted a combined EEG/MEG examination chronologically very close to the neuropsychological assessment and still found no correlation between the number of spikes and the cognitive results.…”

Section: Relationship Between Neuropsychological Data and Clinical Fementioning

confidence: 99%

Frontal Lobe Epilepsies: Neuropsychological and Behavioral Consequences in Children

Vago¹,

Bulgheroni²,

Franceschetti³

et al. 2011

Epilepsy in Children - Clinical and Social Aspects

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Progressive neurocognitive decline in two children with Dravet syndrome, de novo SCN1A truncations and different epileptic phenotypes

Riva

Vago

Pantaleoni

et al. 2009

American J of Med Genetics Pt A

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Dravet syndrome, often caused by mutations of SCN1A-gene, presents with prolonged clonic, generalized or unilateral seizures often occurring with fever during the first year of life, followed by usually severe epilepsy. The EEG, normal at the outset, later shows generalized and focal epileptic activities. The psychomotor development deteriorates, but little is known about the time course of the cognitive impairment and its relationship with seizures severity. We describe here the progressive neurocognitive decline in two children (one male), carrying de novo SCN1A truncating mutations and presenting with different epileptic phenotypes. The children were longitudinally assessed from the ages of 11 and 23 months until the age of 7 and 8 years, using the same scales to measure the developmental competence in various domains. Both had seizures during the first year of life, unilateral clonic in one and myoclonic in the other, but the subsequent epilepsy severity and the characteristics of the EEG diverged. One child had drug-resistant but rare generalized seizures and isolated EEG spike-wave paroxysms, while the other developed extremely frequent clusters of polymorphic seizures and generalized plus multifocal EEG epileptic activities. MRI was normal in both. A clear developmental delay begun before the age of 2 years in both children and the cognitive profile continued to worse, with some differences between different domains, irrespectively to the different course of their epileptic histories. Our observations are consistent with the hypothesis that SCN1A-mutations can be responsible not only for epilepsy, but also for early and progressive severe mental impairment.

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Verbal dichotic listening performance and its relationship with EEG features in benign childhood epilepsy with centrotemporal spikes

Cited by 39 publications

References 38 publications

Benign childhood epilepsy with centrotemporal spikes: word and pseudoword discrimination

Benign childhood epilepsy with centrotemporal spikes: word and pseudoword discrimination

Frontal Lobe Epilepsies: Neuropsychological and Behavioral Consequences in Children

Progressive neurocognitive decline in two children with Dravet syndrome, de novo SCN1A truncations and different epileptic phenotypes

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