Verbal memory impairment in new onset bipolar disorder: Relationship with frontal and medial temporal morphology

Chakrabarty, Trisha; Kozicky, Jan-Marie; Lam, Raymond W.; Yatham, Lakshmi N.

doi:10.3109/15622975.2014.1000373

Cited by 11 publications

(9 citation statements)

References 81 publications

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“…This may reflect a delay in the normal process of cortical thinning through adolescence and young adulthood in these patients; alternatively, regional increases in frontal GMV may evolve in adolescence as a compensatory response to pathological brain changes elsewhere. 40 Previous analyses in the STOP-EM cohort have associated higher subcortical GMV with poorer cognitive performance, 41,42 and attenuated longitudinal decreases in GM density and relative GMV/ WMV have also been demonstrated in some studies of first episode schizophrenia compared to age matched controls. 43,44 While acknowledging the inconsistencies in the literature, the above suggests that there may be a shared neurodevelopmental pathophysiology between the GI group of first episode BD patients and schizophrenia, further evidenced by findings that GI patients with longer duration BD display similar cognitive profiles as severely impaired patients with schizophrenia.…”

Section: Discussionmentioning

confidence: 96%

Cognitive subgroups in first episode bipolar I disorder: Relation to clinical and brain volumetric variables

Chakrabarty

Sawatzky

et al. 2020

Acta Psychiatr Scand

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Objective Distinct cognitive subgroups are seen in patients with long duration bipolar I disorder (BDI), possibly reflective of underlying pathophysiological differences. It is unknown whether such cognitive heterogeneity is present at illness onset. We applied latent class analysis (LCA) to cognitive test scores in first episode BDI patients. Exploratory analysis elucidated whether impaired subgroups were characterized by ‘early neurodevelopmental’ (low premorbid IQ and intracranial volume) versus ‘later neurodevelopmental’ (decline from premorbid to current IQ, changes in relative grey (GM)/white (WM) matter volumes) pathology. Methods Recently recovered first manic episode BDI patients (n = 91) and healthy controls (HC, n = 63) comprised the study sample. LCA identified subgroups based on processing speed, verbal memory, non‐verbal memory, executive functioning, attention and working memory scores. Subgroups were compared amongst each other and HC on premorbid/current IQ, intracranial (ICV), total brain and regional volumes. Results Three cognitive subgroups emerged: (i) globally impaired (GI, n = 31), scoring 0.5‐1 SD below demographically corrected norms across domains, (ii) selectively impaired (SI, n = 47), with predominant processing speed deficits and (iii) high performing (HP, n = 13), with above‐average cognitive performance. GI patients showed a ‘later neurodevelopmental’ pattern, with normal ICV, significant decline from premorbid to current IQ, higher total GM and lower total WM (with respect to total brain volume) versus SI and HC (p = 0.003). GI patients had higher left frontal pole GM versus HC (p < 0.05, FWE corrected). Conclusions A globally impaired patient subgroup is identifiable in first episode BDI, possibly characterized by unique neurodevelopmental pathologic processes proximal to illness onset.

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Section: Discussionmentioning

confidence: 96%

Cognitive subgroups in first episode bipolar I disorder: Relation to clinical and brain volumetric variables

Chakrabarty

Sawatzky

et al. 2020

Acta Psychiatr Scand

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“…There are impairments in total learning as well as short- and long-delay verbal recall, recognition, discriminability and learning slope [ 157 ], associative learning [ 158 ], implicit motor learning [ 159 ], immediate memory [ 134 ], delayed memory [ 34 , 45 , 72 , 77 , 84 , 85 , 94 , 108 , 160 ], non-verbal memory [ 161 ], visual memory [ 38 , 43 , 44 , 74 , 79 , 102 , 108 , 111 ], autobiographical [ 162 , 163 ] and prospective memory [ 164 ]. It has been shown that prospective memory deficits [ 165 ] and short-term non-affective memory [ 166 ] are also present in remitted BD patients suggesting that they constitute a trait deficit.…”

Section: Reviewmentioning

confidence: 99%

The neurocognitive functioning in bipolar disorder: a systematic review of data

Tsitsipa

Fountoulakis

2015

Ann Gen Psychiatry

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Background: During the last decades, there have been many different opinions concerning the neurocognitive function in Bipolar disorder (BD). The aim of the current study was to perform a systematic review of the literature and to synthesize the data in a comprehensive picture of the neurocognitive dysfunction in BD. Methods: Papers were located with searches in PubMed/MEDLINE, through June 1st 2015. The review followed a modified version of the recommendations of the Preferred Items for Reporting of Systematic Reviews and MetaAnalyses statement. Results:The initial search returned 110,403 papers. After the deletion of duplicates, 11,771 papers remained for further evaluation. Eventually, 250 were included in the analysis. Conclusion:The current review supports the presence of a neurocognitive deficit in BD, in almost all neurocognitive domains. This deficit is qualitative similar to that observed in schizophrenia but it is less severe. There are no differences between BD subtypes. Its origin is unclear. It seems it is an enduring component and represents a core primary characteristic of the illness, rather than being secondary to the mood state or medication. This core deficit is confounded (either increased or attenuated) by the disease phase, specific personal characteristics of the patients (age, gender, education, etc.), current symptomatology and its treatment (especially psychotic features) and long-term course and long-term exposure to medication, psychiatric and somatic comorbidity and alcohol and/or substance abuse.

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“…Besides mood instability, neurocognitive dysfunction is another core feature of BD, which not only present in affective episodes, but also in euthymic periods. The neurocognitive dysfunctions involve multiple cognitive processes, including memory, attention, reward and executive function (2)(3)(4)(5). Executive dysfunction is an important domain in BD, even considered as the specific deficit in BD.…”

Section: Introductionmentioning

confidence: 99%

Disturbances of Dynamic Function in Patients With Bipolar Disorder I and Its Relationship With Executive-Function Deficit

et al. 2020

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Abnormity in brain regional function and interregional cooperation have been linked with the dysfunction during cognitive and emotional processing in bipolar disorder (BD) patients. Recent evidences have suggested that brain function is not static but temporal dynamic. In present study, we aimed to characterize the temporal dynamics of regional function and interregional cooperation in BD and its relationship with executive dysfunction, an important deficit in BD. Resting-state functional MRI was performed in patients with bipolar I disorder (BDI) (n = 18) and healthy controls (HCs, n = 19). We first assessed local-function temporal variety with dynamic amplitude of low-frequency fluctuation (dALFF). Region with significant inter-groups difference in dALFF was chosen as a seed to calculate inter-regions connective temporal variety with dynamic functional connectivity (dFC). The executive function was measured by Verbal Fluency Test (VFT). The relationship between executive function and brain dynamics were examined. Compared with HC, the BDI group showed decreased dALFF (less temporal variability) in the posterior cingulate cortex (PCC) and decreased dFC between PCC and medial prefrontal cortex (mPFC). The PCC-mPFC dFC was positively associated with VFT in BDI patients, but not in HC. These findings implicated the reduced temporal variability in local region and inter-regions cooperation in BDI, which may be a neural substrate of executive-function deficit in BDI.

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Verbal memory impairment in new onset bipolar disorder: Relationship with frontal and medial temporal morphology

Abstract: These results suggest that anomalous MT functioning is involved with VM impairment early in the course of BDI.

Cited by 11 publications

References 81 publications

Cognitive subgroups in first episode bipolar I disorder: Relation to clinical and brain volumetric variables

Cognitive subgroups in first episode bipolar I disorder: Relation to clinical and brain volumetric variables

The neurocognitive functioning in bipolar disorder: a systematic review of data

Disturbances of Dynamic Function in Patients With Bipolar Disorder I and Its Relationship With Executive-Function Deficit

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