Verbreitung von Hantavirusinfektionen in Deutschland

Ulrich, Rainer G.; Meisel, Helga; Schütt, M.; Schmidt, Jonas; Kunz, Andrea; Klempa, Boris; Niedrig, Matthias; Pauli, Georg; Krüger, Detlev H.; Koch, Judith

doi:10.1007/s00103-004-0858-8

Cited by 31 publications

(9 citation statements)

References 57 publications

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“…Puumala virus (PUUV) harbored by the bank vole Myodes glareolus (Clethrionomys glareolus) was identified as the causative agent of NE, a less severe form of HFRS (Brummer-Korvenkontio et al, 1980). All these Microtus-associated hantaviruses seem to have no or little pathogenic potential in humans (Vapalahti et al, 1996b;Schultze et al, 2002;Clement et al, 2003;Ulrich et al, 2004). Interestingly, PHV-related hantaviruses were identified in other Microtus species in North America, e.g., Isla Vista virus in Microtus californicus, and in Europe, for example, Tula virus in M. arvalis and M. levis (synonym M. rossiaemeridionalis; Plyusnin et al, 1994;Sibold et al, 1995;Song et al, 1995).…”

Section: Discovery Of Hantavirusesmentioning

confidence: 99%

Hantavirus Emergence in Rodents, Insectivores and Bats

Schlegel

Jacob

Krüger

et al. 2014

The Role of Animals in Emerging Viral Diseases

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Section: Discovery Of Hantavirusesmentioning

confidence: 99%

Hantavirus Emergence in Rodents, Insectivores and Bats

Schlegel

Jacob

Krüger

et al. 2014

The Role of Animals in Emerging Viral Diseases

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“…In Germany, most NE cases are due to autochthonous PUUV infections. This is reflected in results of large-scale seroepidemiological studies as well as in the number of NE cases recorded since the introduction of the German Federal Protection against Infection Act in 2001 [24,25]. The increased number of cases observed in 2005 (447 cases), in 2007 (1,688 cases) and in 2010 (2,016 cases) were caused by PUUV outbreaks mainly affecting Baden-Wuerttemberg, Bavaria, North Rhine Westphalia and Lower Saxony (Robert Koch-Institut: SurvStat, http://www3.rki.de/SurvStat, 16th March 2011; [26][27][28]).…”

Section: Introductionmentioning

confidence: 95%

Phylogenetic analysis of Puumala virus subtype Bavaria, characterization and diagnostic use of its recombinant nucleocapsid protein

et al. 2011

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Puumala virus (PUUV) is the predominant hantavirus species in Germany causing large numbers of mild to moderate cases of haemorrhagic fever with renal syndrome (HFRS). During an outbreak in South-East Germany in 2004 a novel PUUV subtype designated Bavaria was identified as the causative agent of HFRS in humans [1]. Here we present a molecular characterization of this PUUV strain by investigating novel partial and almost entire nucleocapsid (N) protein-encoding small (S-) segment sequences and partial medium (M-) segment sequences from bank voles (Myodes glareolus) trapped in Lower Bavaria during 2004 and 2005. Phylogenetic analyses confirmed their classification as subtype Bavaria, which is further subdivided into four geographical clusters. The entire N protein, harbouring an amino-terminal hexahistidine tag, of the Bavarian strain was produced in yeast Saccharomyces cerevisiae and showed a slightly different reactivity with N-specific monoclonal antibodies, compared to the yeast-expressed N protein of the PUUV strain Vranica/Hällnäs. Endpoint titration of human sera from different parts of Germany and from Finland revealed only very slight differences in the diagnostic value of the different recombinant proteins. Based on the novel N antigen indirect and monoclonal antibody capture IgG-ELISAs were established. By using serum panels from Germany and Finland their validation demonstrated a high sensitivity and specificity. In summary, our investigations demonstrated the Bavarian PUUV strain to be genetically divergent from other PUUV strains and the potential of its N protein for diagnostic applications.

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“…Since 2001, human hantavirus infections have been notifiable in Germany and a total of 10,403 cases were recorded until December 2016 (Robert Koch Institute: SurvStat@RKI 2.0, https://survstat.rki.de , data status: 31.12.2016). The geographical distribution of human cases in Germany is heterogeneous, with the majority reported from highly endemic regions in southern, western and north-western Germany [ 5 , 14 – 16 ]. In outbreak years, the number of human NE cases rises to about 2000 in Germany (SurvStat@RKI 2.0, https://survstat.rki.de , data status: 17.05.2016).…”

Section: Introductionmentioning

confidence: 99%

Puumala hantavirus infections in bank vole populations: host and virus dynamics in Central Europe

et al. 2017

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BackgroundIn Europe, bank voles (Myodes glareolus) are widely distributed and can transmit Puumala virus (PUUV) to humans, which causes a mild to moderate form of haemorrhagic fever with renal syndrome, called nephropathia epidemica. Uncovering the link between host and virus dynamics can help to prevent human PUUV infections in the future. Bank voles were live trapped three times a year in 2010–2013 in three woodland plots in each of four regions in Germany. Bank vole population density was estimated and blood samples collected to detect PUUV specific antibodies.ResultsWe demonstrated that fluctuation of PUUV seroprevalence is dependent not only on multi-annual but also on seasonal dynamics of rodent host abundance. Moreover, PUUV infection might affect host fitness, because seropositive individuals survived better from spring to summer than uninfected bank voles. Individual space use was independent of PUUV infections.ConclusionsOur study provides robust estimations of relevant patterns and processes of the dynamics of PUUV and its rodent host in Central Europe, which are highly important for the future development of predictive models for human hantavirus infection risk.

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Verbreitung von Hantavirusinfektionen in Deutschland

Cited by 31 publications

References 57 publications

Hantavirus Emergence in Rodents, Insectivores and Bats

Hantavirus Emergence in Rodents, Insectivores and Bats

Phylogenetic analysis of Puumala virus subtype Bavaria, characterization and diagnostic use of its recombinant nucleocapsid protein

Puumala hantavirus infections in bank vole populations: host and virus dynamics in Central Europe

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