Verdamicin, a New Broad Spectrum Aminoglycoside Antibiotic

Weinstein, Marvin; Wagman, G. H.; Marquez, Joseph A.; Testa, R. T.; Waitz, J. A.

doi:10.1128/aac.7.3.246

Cited by 45 publications

(28 citation statements)

References 3 publications

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“…Isolates were further characterized using molecular sequencing [58] methods. For molecular characterization the PCR products were sequenced at the Australian Genome Research Facility, Brisbane.…”

Section: Methodsmentioning

confidence: 99%

The Occurrence of Bioactive Micromonosporae in Aquatic Habitats of the Sunshine Coast in Australia

2008

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Abstract:Screening strategies based on the ecological knowledge of antibiotic producing microorganisms and their roles in the natural environment are being increasingly employed in the search for novel antibiotic agents. Micromonosporae are common inhabitants of aquatic habitats and have proved to be a continuing source of novel bioactive compounds including antibacterial and antitumor agents. The ecological distribution and frequency of bioactive micromonosporae in Sunshine Coast region aquatic habitats were studied through a range of selective isolation procedures designed to negatively select against the isolation of unwanted microbial taxa commonly associated with marine environments. It was revealed that bioactive compound producing species of micromonosporae were present in the aquatic habitats of the Sunshine Coast region in Australia.

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Section: Methodsmentioning

confidence: 99%

The Occurrence of Bioactive Micromonosporae in Aquatic Habitats of the Sunshine Coast in Australia

2008

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“…Gentamicin is active against Staphylococcus aureus, members of the family Enterobacteriaceae and, very importantly, Pseudomonas aeruginosa (17). Disturbingly, however, reports of resistance to gentamicin among members of the family Enterobacteriaceae have begun to appear (11).…”

mentioning

confidence: 99%

In Vitro Activity, Synergism, and Testing Parameters of Amikacin, with Comparisons to Other Aminoglycoside Antibiotics

Kelly

Matsen

1976

Antimicrob Agents Chemother

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The activity of the new aminoglycoside antibiotic, amikacin, was evaluated in vitro against 219 clinical bacterial isolates. One hundred eighty-nine of the 219 strains had agar dilution minimal inhibitory concentration values of 8.0 ug/ml or less for amikacin. Comparative agar dilution studies were performed for gentamicin, kanamycin, and tobramycin. Gentamicin was the most active overall, but tobramycin and amikacin also had significant activity against most bacterial groups. The effects of divalent cations on the susceptibility ofPseudomonas aeruginosa to amikacin were evaluated, and the minimal inhibitory concentration values varied sixfold over a range of divalent cation concentrations from 0.2 to 8.75 mg%o. The effects of media and inoculum size on disk susceptibility testing with amikacin were also evaluated. In addition, a synergistic interaction between carbenicillin and amikacin against P. aeruginosa was demonstrated. Amikacin appears to be a promising new broad spectrum antimicrobial agent.

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“…Gentamicin, sisomicin, and their derivatives are pseu dotrisaccharides containing 4, 6-disubstituted-2-deoxystreptamine and are mainly produced by various species of Micro monospora. The commercially available gentamicin mainly consists of gentamicin Ci, C2 and C |a which were first reported by Weinstein et al [1] to be produced by M. purpurea. The Micromonospora strains, especially M. sagamiensis, are able to transform gentamicin Cia into C2b [2]; this new molecule has been called sagamicin ( fig.…”

Section: Introductionmentioning

confidence: 99%

Multiple-Dose Pharmacokinetics in Serum and Sputum of Sagamicin Administered Intramuscularly to Patients

Fraschini¹,

Scaglione²,

Scarpazza³

et al. 1987

Chemotherapy

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Sagamicin is an aminoglycosidic antibiotic produced by Micromonospora sagamiensis, chemically related with gentamicin. Single- and multiple-dose pharmacokinetics have been investigated in patients affected by bronchopulmonary infections treated with 60 mg sagamicin i.m. every 12 h. The two concentration-time curves for sputum and serum are parallel; while there is no evidence of accumulation in the serum at the 7th day of treatment, sagamicin concentrations in the sputum are significantly higher on the 7th day, and this is also confirmed by a remarkable difference between the two AUC values. The good penetration power of sagamicin into sputum makes this antibiotic useful for the treatment of infections of the respiratory tract.

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Verdamicin, a New Broad Spectrum Aminoglycoside Antibiotic

Cited by 45 publications

References 3 publications

The Occurrence of Bioactive Micromonosporae in Aquatic Habitats of the Sunshine Coast in Australia

The Occurrence of Bioactive Micromonosporae in Aquatic Habitats of the Sunshine Coast in Australia

In Vitro Activity, Synergism, and Testing Parameters of Amikacin, with Comparisons to Other Aminoglycoside Antibiotics

Multiple-Dose Pharmacokinetics in Serum and Sputum of Sagamicin Administered Intramuscularly to Patients

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