Vergelijkende studie van dermato-cosmetische producten voor de droge tot zeer droge huid. Objectieve evaluatie aan de hand van efficiëntiemetingen

Beneficial effects of a skin tolerance‐tested moisturizing cream on the barrier function in experimentally‐elicited irritant and allergic contact dermatitis

“…Typical hydrating creams are non‐ionic o/w emulsions containing natural moisturizing factors (NMFs) and mixtures of lipids of both mineral and vegetable origin (14). In previous work, the efficacy of different moisturizing creams has been tested for their hydrating potential using capacitance measurements and their effect on the barrier using TEWL measurements (15, 16). Consequently, the working hypothesis of our laboratory became as follows: a hydrating cream is considered to be efficient when its application on dry skin improves SC hydration and favours lower TEWL values.…”

“…This hypothesis has been taken as the basic strategy to develop the skin care product used in the present study. When applied to elderly skin during a 14‐day test (12 females, mean age 56±5 years old), a hydrating capacity of 30% and an effect on TEWL of 40% were measured (15). However, since the cream had to be tested on experimentally induced ICD and ACD, it was ethically necessary to run some additional skin compatibility tests prior to application (7).…”