Vergleichende Untersuchungen �ber die Wirkung von Pyrazolen und Antihistaminen bei verschiedenen Arten der experimentellen Entz�ndung

Wilhelmi, G; Domenjoz, R

doi:10.1007/bf00245674

Cited by 18 publications

(7 citation statements)

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“…)-induced erythaema of the guinea-pig skin. The studies of Wilhelmi (1949Wilhelmi ( , 1950 and Wilhelmi & Domenjoz (1951) demonstrated that pretreatment of the guinea-pig with certain anti-rheumatic drugs delayed the u.v.-induced erythaema. Winder, Wax, Burr, Been & Rosiere (1958) showed the specificity of this test in detecting non-steroidal anti-rheumatic compounds of clinical value and their method is widely used for evaluating the anti-inflammatory activity of new compounds.…”

Section: Introductionmentioning

confidence: 99%

Delayed manifestation of ultraviolet reaction in the guinea‐pig caused by anti‐inflammatory drugs

Gupta¹,

Levy²

1973

British J Pharmacology

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Summary Exposure of depilated skin of guinea‐pig to ultraviolet (u.v.) light for 20 s produces a prolonged inflammatory response. The erythaema becomes evident within 15–30 min after the exposure and progressively increases in intensity reaching its maximum by 4–6 hours. The erythaema persists over 24 hours. Increase in vascular permeability is biphasic with an early short‐lived rise peaking at 0·5 h and a prolonged secondary response peaking at 9–12 h and lasting over 48 hours. In presence of aspirin, phenylbutazone and indomethacin, administered prior to u.v. exposure, the inflammatory reaction is partially suppressed, depending upon the dose. The drugs are ineffective in aborting or minimizing the response when given after the inflammation is established. Corticosteroids fail to influence the u.v. inflammation in this test. The significance of these findings is discussed.

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Section: Introductionmentioning

confidence: 99%

Delayed manifestation of ultraviolet reaction in the guinea‐pig caused by anti‐inflammatory drugs

Gupta¹,

Levy²

1973

British J Pharmacology

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“…UVB-induced cutaneous damage leads to erythema, one of the cardinal signs of inflammation. This UV-induced erythema can also be produced in experimen tal animals, especially the guinea pig, and has often been used as a useful model to evaluate the anti-inflammatory activity of non-steroidal anti-rheumatic drugs (3)(4)(5)(6). Non-steroidal anti-inflammatory drugs (NSAIDs) sup press the early stages of erythema very well, but this sup pressive efficacy gradually weakens after the initial stage, whether or not the skin is additionally treated with NSAID.…”

mentioning

confidence: 99%

Streptozocin-Diabetes Modifies Acetylcholine Release from Mouse Phrenic Nerve Terminal and Presynaptic Sensitivity to Succinylcholine

Nose

Tsurumi

1993

Japanese Journal of Pharmacology

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ABSTRACT-This study was conducted to quantify the intensity of ultraviolet (UV) erythema in guinea pigs, a method for evaluating anti-inflammatory drugs, and to clarify any correlation of erythema with cutaneous blood flow. Skin color and cutaneous blood flow in non-administered and indomethacin administered animals were measured by a colorimeter and a laser Doppler flowmeter over time after UV irradiation treatment. Skin color was indicated by a XYZ colorimetric system and L*a*b* color space. In either colorimetric system, the values of two indices, x and y or a* and b*, increased along with the inten sification of erythema. The increase in the chroma (C*) value calculated from a* and b* was UV-dose dependent. This value was significantly suppressed by indomethacin 0.5-4 hr after irradiation, and it was found to be a clear and sensitive index for evaluating the suppressive effect of drugs. Cutaneous blood flow also increased with UV irradiation. Indomethacin significantly suppressed this increase 2-3 hr after UV ir radiation. The changes of cutaneous blood flow correlated with those of C*. These results suggested C* was a suitable parameter to quantify UV erythema, and the change of skin color in UV erythema reflected the change of cutaneous blood flow.

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“…Other mediators of inflammation cause skin vasodilatation and it is likely that these play a role in the erythema observed following exposure to ultraviolet irradiation. This explains why aspirin and related drugs will delay, but cannot completely abolish the erythema (Wilhemi & Domenjoz, 1951). Aspirin, indomethacin and other cyclo-oxygenase inhibitors, when applied locally or when given orally, have been found useful in reducing the erythema due to sunburn in man (Snyder & Eaglstein, 1974b;Gruber et al, 1972;Plummer, Hensby, Black et al, 1977).…”

Section: Interaction Of Prostaglandins In the Kidneymentioning

confidence: 99%

Potential therapeutic applications of aspirin and other cyclo‐oxygenase inhibitors.

Ae¹,

Rosenberg²

1980

Brit J Clinical Pharma

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1 The ubiquitous actions of the cyclo‐oxygenase inhibitors are described. 2 These include the inhibitory effect on prostaglandin synthesis and the direct effect of aspirin on lymphocytes and their ability to produce lymphokines. 3 Aspirin reduces some types of platelet aggregation possibly involving inhibition of the precursors of thromboxane A2 and prostacyclin. 4 The therapeutic implications in relation to transient ischaemic attacks, coronary artery disease and reno‐allograft rejection are discussed. 5 The beneficial and adverse effects on the gastro‐intestinal tract are described. 6 The effects of aspirin‐like drugs on the genito‐urinary tract are described with particular reference to their adverse effects on labour and their therapeutic effect on dysmenorrhoea.

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Vergleichende Untersuchungen �ber die Wirkung von Pyrazolen und Antihistaminen bei verschiedenen Arten der experimentellen Entz�ndung

Cited by 18 publications

References 0 publications

Delayed manifestation of ultraviolet reaction in the guinea‐pig caused by anti‐inflammatory drugs

Delayed manifestation of ultraviolet reaction in the guinea‐pig caused by anti‐inflammatory drugs

Streptozocin-Diabetes Modifies Acetylcholine Release from Mouse Phrenic Nerve Terminal and Presynaptic Sensitivity to Succinylcholine

Potential therapeutic applications of aspirin and other cyclo‐oxygenase inhibitors.

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