Vergleichende Untersuchungen der Hämolyse von Blutpumpen verschiedener Bauart

Hoeven, J. G. Th. van der; Kilic, Ayhan; Vogel, P.; Loudovici, D.A.; Große-Siestrup, Christian; Affeld, K.

doi:10.1515/bmte.1998.43.s1.332

Cited by 2 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9,10 However, roller pumps have a haemolysis level that is 10 times higher. 8 However, these pumps are mainly used in clinical practice for short-term applications with low flow rates, such as dialysis. For ECMO, they are often been replaced by centrifugal pumps that are less critical due to haemolysis.…”

Section: Discussionmentioning

confidence: 99%

“…A haemolysis level of 0.19-0.26 g/100 L was measured in vitro in roller pumps. 8 An in vitro comparison between three centrifugal pumps for extracorporeal short-term support showed that the PediVas pump (Levitronix LLC, Waltham, MA, USA) caused the lowest haemolysis level and the Rotaflow (MAQUET Cardiopulmonary AG, Hirrlingen, Germany) and Medos Deltastream DP3 (MEDOS Medizintechnik GmbH, Stolberg, Germany) about twice as high. It was assumed that the design of the PediVas pump with non-contact magnetic bearings greatly minimizes haemolysis.…”

Section: Haemolysis In Blood Pumpsmentioning

confidence: 99%

See 1 more Smart Citation

Haemolysis induced by mechanical circulatory support devices: unsolved problems

Köhne

2020

Perfusion

View full text Add to dashboard Cite

Since the use of continuous flow blood pumps as ventricular assist devices is standard, the problems with haemolysis have increased. It is mainly induced by shear stress affecting the erythrocyte membrane. There are many investigations about haemolysis in laminar and turbulent blood flow. The results defined as threshold levels for the damage of erythrocytes depend on the exposure time of the shear stress, but they are very different, depending on the used experimental methods or the calculation strategy. Here, the results are resumed and shown in curves. Different models for the calculation of the strengths of erythrocytes are discussed. There are few results reported about tests of haemolysis in blood pumps, but some theoretical approaches for the design of continuous flow blood pumps according to low haemolysis have been investigated within the last years.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Haemolysis In Blood Pumpsmentioning

confidence: 99%

Haemolysis induced by mechanical circulatory support devices: unsolved problems

Köhne

2020

Perfusion

View full text Add to dashboard Cite

show abstract

The isolated normothermic hemoperfused porcine forelimb as a test system for transdermal absorption studies

Wagner¹,

Nogueira

Paul

et al. 2003

Journal of Artificial Organs

View full text Add to dashboard Cite

For transdermal absorption studies, a porcine skin model that maintains the characteristics of the skin as close to physiological conditions as possible should be established because of the close similarity of porcine and human skin. Perfusion flow, glucose concentration, and oxygen supply were varied and organ resistance and lactate concentration were measured as parameters for organ performance. Transdermal absorption studies were performed using nitroglycerin or estradiol as test solutes. By the use of a standardized perfusion apparatus, limbs were perfused with a normothermic blood/electrolyte mix over a 6-h period. Organ resistance and lactate concentration were lower in limbs perfused with high flow as compared to perfusion with low flow. However, high perfusion flow caused an initial increase of hemolysis in the venous perfusate resulting in a higher concentration of free hemoglobin compared to low perfusion flow conditions. Glucose level in the perfusate was maintained within the porcine physiological range. By applying optimized conditions, the transdermal absorption of nitroglycerin or estradiol released from transdermal therapeutic systems was investigated. A time-dependent accumulation of the substances in the perfusion medium was observed, indicating the continuous uptake via the skin. After 6 h (nitroglycerin) or 5 h (estradiol) of perfusion, test substances accumulated to concentrations comparable to those described in humans. In conclusion the perfused porcine limb may serve as a reliable test system for transdermal absorption studies. The model is suited to the replacement of animal testing and has a higher predictive potential because of the similarities of porcine and human skin.

show abstract

Vergleichende Untersuchungen der Hämolyse von Blutpumpen verschiedener Bauart

Cited by 2 publications

References 3 publications

Haemolysis induced by mechanical circulatory support devices: unsolved problems

Haemolysis induced by mechanical circulatory support devices: unsolved problems

The isolated normothermic hemoperfused porcine forelimb as a test system for transdermal absorption studies

Contact Info

Product

Resources

About