Vergleichende Untersuchungen über die Bildung von Adenosin im Myokard verschiedener Tierspecies bei Sauerstoffmangel

Gerlach, E.; Deüticke, B.; Dierkesmann, R

doi:10.1007/bf01716603

Cited by 24 publications

(3 citation statements)

References 8 publications

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“…The most important difference, however, from the other species is that in the guinea-pig there is a marked accumulation of IMP. These results are in agreement with a very early study (8) where it was shown that in the guinea-pig, after 20 min of ischemia, ADO accumulation was barely detectable (0.01 ~tmole 9 g-t wet weight versus 0.50 in the rat) and IMP was highest of all 6 species tested. In the same study it was found that dipyridamole (3 mg. kg-1; i.v.)…”

Section: A Tissue Levelssupporting

confidence: 95%

Formation and release of nucleosides in the ischemic myocardium. Is the guinea-pig the exception?

1985

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In this study evidence is provided to suggest that nucleoside formation with hypoxia in myocardial tissue from the guinea-pig follows a different course from that in the rat, rabbit or dog. 1) After ischemia, tissue levels of adenosine remain barely detectable in the guinea-pig but rise considerably in the rat and the dog. 2) IMP, remaining almost absent in the dog, does not change in the rat but strongly increases (X 6) in the guinea-pig heart with ischemia. 3) Mioflazine, a nucleoside transport inhibitor, completely reverses the ratio adenosine/inosine in dog myocardium after 8 min of ischemia, making adenosine by far the major nucleoside. No effect could be detected in the guinea-pig. 4) In contrast with the rat and rabbit, ischemia in the guinea-pig does not lead to any considerable release of adenosine upon reperfusion. 5) In the rabbit, the presence of a nucleoside transport inhibitor completely reverses the adenosine/inosine ratio in reperfusates after ischemia. Although the release is strongly inhibited under these conditions in the guinea-pig, adenosine release remains negligible when compared with inosine. 6) Even in the presence of high concentrations of an adenosine deaminase inhibitor, inosine remains the major metabolite released upon reperfusion after ischemia, in the guinea-pig heart.

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Section: A Tissue Levelssupporting

confidence: 95%

Formation and release of nucleosides in the ischemic myocardium. Is the guinea-pig the exception?

1985

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“…1). Glycogen, as the chief myocardial substrate for glycolysis, decreases to a minimal level within [4][5] minutes, while glucose remains unchanged during the entire period of asphyxia. The intermediates of the glycolytic pathway which were studied are distinctly elevated as long as glycogenolysis takes place.…”

mentioning

confidence: 99%

“…This relation is also demonstrated by the increased ATP restoration under the influence of agents, such as dipyridamol (Persantin@), Isselhardlz) . This agent interferes with the degradation of adenosine and its depletion from the site of nucleotide synthesis (Gerlach et al3,4,Kubler [7 Asphyxia: 1 X 5 min.…”

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confidence: 99%

Metabolism and Function of the Heart During Acute Asphyxia and in Postasphyxial Recovery

Isselhard

1968

Acta Anaesthesiol Scand

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SUMMARY In asphyxia, the energy production by anaerobic glycolysis does not suffice to meet the energy demand of the heart. This energy deficit results in a rapid and complete depletion of creatine phosphate, and in a continuous decrease in ATP and the sum of adenine nucleotides. Upon restoration of the oxygen supply, the creatine phosphate returns to normal within 1‐2 minutes. Restoration of ATP and the sum of adenine nucleotides may require many hours and is determined by the depletion of the degradation products of the nucleotides which takes place during the anaerobic period. In the anaesthetised rabbits subjected to asphyxia myocardial power is rapidly and profoundly depressed, but returns to normal within 1‐2 minutes if artificial ventilation is applied, and asphyxia has not exceeded 5 minutes. The impaired cardiac performance during asphyxia and its postasphyxial restoration changes with the myocardial creatine phosphate and a small portion of the cellular ATP which is thought to be associated with the contraction process.

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Adenosine and Metabolism—A Brief Historical Note

Fredholm

2012

Adenosine

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Vergleichende Untersuchungen über die Bildung von Adenosin im Myokard verschiedener Tierspecies bei Sauerstoffmangel

Cited by 24 publications

References 8 publications

Formation and release of nucleosides in the ischemic myocardium. Is the guinea-pig the exception?

Formation and release of nucleosides in the ischemic myocardium. Is the guinea-pig the exception?

Metabolism and Function of the Heart During Acute Asphyxia and in Postasphyxial Recovery

Adenosine and Metabolism—A Brief Historical Note

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