Verhaltens�nderung und Neuropathologie bei der 3-Acetylpyridinvergiftung der Ratte

Denk, Helmut; Haider, M.; Kovac, W; Studynka, G.

doi:10.1007/bf00690508

Cited by 53 publications

(9 citation statements)

References 15 publications

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“…Convulsant activity is therefore not necessarily associated with lesions of the hippocampus. This was observed, for instance, in cats treated with strychnine and metrazol (34), in rats injected intraperitoneally with distilled water (20) and in rats treated with 3-AP (8,15,24). In our experiments also and in those of ZEILLER et al (46) there were a number of animals that convulsed after ICHQ or amphetamine in which no lesions were found.…”

Section: The Hippocampus and Energy Metabolismsupporting

confidence: 80%

“…Some authors (15,24) reported that 3-AP treated rats underwent convulsive fits; however, on morphological examination no specific damage to hippocampal neurones was demonstrated (24). Others observed only sporadic convulsions (8) or none at all (9) after administration of 3-AP to rats. Structural changes were found in neurones of the brain stem, mainly in the inferior olivary complex, but never in the hippocampus.…”

Section: Introductionmentioning

confidence: 99%

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Toxic Encephalopathy with Hippocampal Lesions

Krinke

Pericin

Thomann

et al. 2010

Zentralblatt Für Veterinärmedizin Reihe A

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Summary Types of necrotic encephalopathy associated with hippocampal lesions observed in mice treated with amphetamine and 5‐chloro‐7‐iodo‐8‐quinolinol and in dogs treated with atropine and histamine are described. Although these findings of hippocampal lesions of an ischaemic type do not seem to have any predictive value for the detection of specific neurotoxicity, they are considered to reflect severe systemic toxicity of the chemical agents in question. Zusammenfassung Toxische Enzephalopathie mit Hippocampus‐Läsionen Bei Mäusen, die mit Amphetamin und 5‐chloro‐7‐iodo‐8‐quinolinol sowie Hunden, welche mit Atropin und Histamin behandelt wurden, werden Typen von nekrotisierenden Enzephalopathien mit Läsionen im Hippocampus beschrieben. Obwohl diesen ischämischen Hippocampus‐Läsionen anscheinend keine Bedeutung hinsichtlich der Feststellung einer spezifischen Neurotoxizität zukommt, dürften sie immerhin auf eine schwere allgemeine Toxizität der fraglichen chemischen Agentien hinweisen. Résumé Encéphalopathie toxique avec des lésions de la corne d'Ammon Des types d'encéphalopathies nécrosantes avec des lésions dans la corne d'Ammon sont décrits chez des souris traitées à l'amphétamine et au 5‐chloro‐7‐iodo‐8‐quinolinol et chez des chiens traités à l'atropine et à l'histamine. Bien que ces lésions ichémiques de la corne d'Ammon ne soient pas apparemment une preuve dans la détection d'une neurotoxicité spécifique, il faut néanmoins prendre en considération une toxicité générale grave des agents chimiques évoqués. Resumen Encéfalopatía tóxica con lesiones hipocampales Se describen en ratones que fueron tratados con anfetamina y 5‐cloro‐7‐yodo‐8‐quinolinol, y en perros, tratados con atropina e histamina, tipos de encéfalopatías necróticas con lesiones hipocampales. Aunque a estas lesiones isquémicas en el hipocampo no le corresponde, al parecer, ninguna importancia vaticinatoria con respecto a la detección de una neurotoxicidad específica, podrían reflectar de todos modos hacia una toxicidad sistémica grave de los agentes químicos problemáticos.

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Section: The Hippocampus and Energy Metabolismsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Toxic Encephalopathy with Hippocampal Lesions

Krinke

Pericin

Thomann

et al. 2010

Zentralblatt Für Veterinärmedizin Reihe A

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“…Given the fact that the failure of ILR rats to enter the dark compartment during the retrieval test is not due to motor problems that would prevent the animals moving easily from the light to the dark compartment (LIR rats, which had similar motor disabilities, entered it at the time of the initial conditioning), it can be assumed that lesion of the IOC does not disrupt memory of the previous nociceptive experience. However, in an active avoidance conditioning task in the rat, Denk et al (1968) pointed out that following 3-AP (65 mg/kg -1) administration the acquisition of the conditioning was delayed, the score was lower than that of controls and retention was partly disrupted. According to the authors these learning disorders cannot be explained from the neuropathological findings.…”

Section: Discussionmentioning

confidence: 96%

“…The protocol used in this study allowed a very high survival percentage since LDso is usually found to be 65 mg/kg (Denk et al 1968;Desclin and Escubi 1974). In fact, the time interval between the injections of 3-AP and niacinamide is crucial in determining survival.…”

Section: Discussionmentioning

confidence: 99%

Effects of lesion of the inferior olivary complex by 3-acetylpyridine on learning and memory in the rat

1992

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DA/HAN-strained male rats (pigmented rats) were submitted to two experimental tasks consisting of spatial learning (water-escape) and a passive avoidance conditioning. Both these tasks were performed by different animals. In order to destroy the inferior olivary complex, the animals were injected with 3-acetylpyridine either 9 days prior to the initial learning session or 24 h after completion of the learning task. They were retested (retrieval test) 10 days after the initial learning was achieved. Learning and retention were compared to those noted in control rats. Administration of 3-acetylpyridine before the initial learning did not prevent the spatial learning but the scores were greatly altered and the number of trials needed to reach the fixed learning criterion was much greater than in controls. However, 10 days later the animals had memorized their initial experience. Injection of 3-acetylpyridine after the initial learning session impaired memory: the animals had completely forgotten their initial learning. It can therefore be concluded that lesion of the afferent climbing fibres to the cerebellar cortex alters learning and retention of a spatial task. Such a lesion does not interfere with learning and retention of a passive avoidance conditioning, since in this condition the experimental animals injected with 3-acetylpyridine either before or after the initial learning behave similarly to controls. The effects of the inferior olivary complex lesion are obviously different according to the task to be learnt, suggesting that these two tasks do not require the integrity of the same nervous structures.

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“…Ideally, one would like to use a neurotoxin relatively specific for the neurons in question. 3-Acetylpyridine (3-AP) is a competitive antagonist of a nicotinic acid with marked neurotoxic potency [Hicks, 1955;Coggeshall and MacLean, 1958;Koikegami and Fuse, 1961;Lierse, 1965;Denk et al, 1968;Herken, 1968;Desclin and Escubi, 19741. lntraperitoneal administration of this drug to mice has been reported to produce selective hippocampal lesions with loss of ncurons in areas CA3 and CA4 [Coggeshall and MacLean, 19581.…”

Section: Nt Ro D U Ct I 0 Nmentioning

confidence: 99%

Learning deficits on avoidance task and hippocampal lesions in area CA3 following intraperitoneal administration of 3‐acetylpyridine

Ozaki

Murakami

Shimada

1983

J of Neuroscience Research

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Young adult mice of the ddN-F26 strain were given a single intraperitoneal injection of 3-acetylpyridine (3-AP) at a dosage of 200 mg/kg body weight. Two weeks after this treatment, learning on avoidance task was tested with a training apparatus called a jump-box. Each mouse was subjected to 30 trials of training per week for 3 or 4 weeks. Contrasted to untreated mice, the mean performance of the 3-AP-treated mice on avoidance training was significantly reduced in every weekly training session. However, since the learning scores of individual 3-AP-treated mice were highly varied, these mice were divided into several groups according to the characteristics of their learning patterns in order to analyze the relationships between learning ability and brain damage. It was found that there was a close association between the rate of learning deficits and the degree of destruction of the pyramidal cells in area CA3 of the hippocampus in mice treated with 3-AP. The present data suggest that the area CA3 neurons play an important role on the acquisition of avoidance task and memory formation.

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Verhaltens�nderung und Neuropathologie bei der 3-Acetylpyridinvergiftung der Ratte

Cited by 53 publications

References 15 publications

Toxic Encephalopathy with Hippocampal Lesions

Toxic Encephalopathy with Hippocampal Lesions

Effects of lesion of the inferior olivary complex by 3-acetylpyridine on learning and memory in the rat

Learning deficits on avoidance task and hippocampal lesions in area CA3 following intraperitoneal administration of 3‐acetylpyridine

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