48Various modeling approaches, including fully three-dimensional (3D) models and vertical-49 equilibrium (VE) models, have been used to study the large-scale storage of carbon dioxide 50 (CO 2 ) in deep saline aquifers. 3D models solve the governing flow equations in three spatial 51 dimensions to simulate migration of CO 2 and brine in the geological formation. VE models 52 assume rapid and complete buoyant segregation of the two fluid phases, resulting in vertical 53 pressure equilibrium and allowing closed-form integration of the governing equations in the 54 vertical dimension. This reduction in dimensionality makes VE models computationally much 55 more efficient, but the associated assumptions restrict the applicability of VE models to 56 geological formations with moderate to high permeability. In the present work, we extend the VE 57 models to simulate CO 2 storage in fractured deep saline aquifers in the context of dual-58 continuum modeling, where fractures and rock matrix are treated as porous media continua with 59 different permeability and porosity. The high permeability of fractures makes the VE model 60 appropriate for the fracture domain, thereby leading to a VE-dual continuum model for the dual 61 continua. The transfer of fluid mass between fractures and rock matrix is represented by a mass 62 transfer function connecting the two continua, with a modified transfer function for the VE 63 model based on vertical integration. Comparison of the new model with a 3D-dual continuum 64 model shows that the new model provides comparable numerical results while being much more 65 computationally efficient. 66 67 68 Keywords 69 70 Geologic CO 2 storage 71Fractured rock 72 Dual-continuum models 73 Vertically-integrated models 74 Multi-scale modeling 75 76 77 129 2.1 Three-dimensional and Vertical-equilibrium Models 130 131 Various modeling approaches have been used to model fluid migration in unfractured geological 132 formations. These models solve an appropriate set of governing equations, which provides the 133 spatial and temporal distribution of fluid pressures and fluid saturations in the formation. Here, 134we briefly review fully three-dimensional models that solve governing flow equations in three 135 spatial dimensions, and vertically-integrated models that integrate the governing equations in the 136 vertical dimension using the so-called vertical equilibrium assumption. For more details on 137 modeling approaches applied to geologic carbon storage, the reader is referred to [23, 24]. 138 139