Verkanntes verhornendes Vulvakarzinom bei 40- jähriger Schwangeren

How Can We Treat Vulvar Carcinoma in Pregnancy? A Systematic Review of the Literature

“…Of these, 37 full texts were considered for eligibility, and after reading them, 7 articles were excluded for being unfit according to the inclusion criteria or because they presented scant or aggregated data: details of some additional cases excluded from our review [ 7 , 8 , 9 , 10 ] are presented as Supplementary Materials . Thirty studies were finally included in the review, for a total of 37 patients diagnosed with VSCC during pregnancy [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ].…”

“…The patients’ age range at presentation was 17–41 years (mean 30 years) [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ] ( Table 1 ). The majority of cases was diagnosed in the United States (15 cases) [ 18 , 23 , 27 , 29 , 30 , 31 , 35 , 36 , 37 , 40 , 41 ], 12 in Europe (5 United Kingdom, 3 France, 2 Germany, 1 Belgium, 1 Holland) [ 11 , 12 , 13 , 17 , 20 , 22 , 24 , 26 , 33 , 38 ...…”

“…In 2 (5%) cases the whole vulva was involved by single [ 25 ] or multiple lesion(s) [ 28 ]. In 3 (8%) cases, location was unreported [ 11 , 12 , 16 ]. As regards the concomitant evidence of vulvar condylomas (VCs) see Section 2.16 .…”

“… Discovery during pregnancy without pre-conceptional evidence of vulvar lesions (25/37 cases, 68%) . The VSCCs were identified during the 1st (2/25 cases, 8%) [ 14 , 35 ], 2nd (14/25 cases, 56%) [ 13 , 16 , 18 , 23 , 24 , 28 , 29 , 31 , 32 , 33 , 36 , 37 , 38 , 39 ], or 3rd trimester of pregnancy (9/25 cases, 36%) [ 11 , 12 , 19 , 21 , 26 , 30 , 31 , 36 , 41 ]. Peri-conceptional evidence of a vulvar lesion (3/37 cases, 8%).…”

“…In 32/37 cases (87%), the vulvar lesion was biopsied during pregnancy (25/32 cases, 78%) (range 8–36 GW; mean 23 GW) [ 11 , 12 , 13 , 17 , 18 , 19 , 21 , 23 , 24 , 25 , 26 , 28 , 29 , 30 , 31 , 33 , 34 , 35 , 36 , 38 , 39 , 40 , 41 ], during delivery (when it was discovered) (5/32 cases, 16%) [ 20 , 22 , 27 , 35 , 36 ], or after delivery (2 weeks postpartum: 1 case, unreported time: 1 case) [ 14 , 31 ] ( Table S2 ). In 2 cases, 2 biopsies were performed (33 GW and 4 weeks after delivery [ 26 ]; 10 GW and 22 GW [ 24 ]).…”